A5060883903- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Cardiovascular Health and Disease Prevention
- Parathyroid Disorders and Treatments
- Long-Term Effects of COVID-19
- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 Clinical Research Studies
- Central Venous Catheters and Hemodialysis
- Artificial Intelligence in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Lupus Erythematosus Research
- Folate and B Vitamins Research
- Vitamin C and Antioxidants Research
- Acute Kidney Injury Research
- Complement system in diseases
- Advanced Proteomics Techniques and Applications
- Fibroblast Growth Factor Research
- Economic and Financial Impacts of Cancer
- Tuberous Sclerosis Complex Research
- Vasculitis and related conditions
- Hemodynamic Monitoring and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Multiple and Secondary Primary Cancers
- Pneumocystis jirovecii pneumonia detection and treatment
Beijing Hospital
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Xiamen University
2005
Curcumin, a major yellow pigment and active component of turmeric, has multiple anti-cancer properties. However, its molecular targets mechanisms action on human colon adenocarcinoma cells are unknown. In the present study, we examined effects curcumin proliferation HT-29 by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide method confirmed curcumin-induced apoptosis morphology DNA ladder formation. At same time, p53, phospho-p53 (Ser15), other apoptosis-related proteins such as...
Previous clinical studies found inconsistent relationship between circulating sclerostin levels and treatment outcome in patients undergoing maintenance hemodialysis (MHD). Therefore, this study aimed to assess the associations of with carotid artery atherosclerosis all-cause mortality Chinese MHD.This retrospective assessed 84 MHD at Nephrology Department Beijing Hospital from January April 2012, a median follow-up 61.2 months (range: 11.5 63 months). Carotid intima-media thicknesses...
The outcome of patients with primary membranous nephropathy (pMN) who present nephrotic syndrome (NS) is variable and difficult to predict. goal this study was develop a nomogram predict the risk progression for specific individuals.This retrospective involved biopsy-proven pMN NS treated between January 2012 June 2018. our investigation progression, defined as reduction estimated glomerular filtration rate (eGFR) that equal or over 20% compared baseline at end follow-up onset end-stage...
Abstract Purpose Sclerostin is an antagonist of the Wnt/β-catenin pathway. We previously reported that sclerostin closely related to carotid artery atherosclerosis and long-term outcome in hemodialysis patients. The present study investigated association between sclerostin, renal function, non-dialysis patients with stage 3–5 chronic kidney disease (CKD 3–5ND). Methods A total 140 CKD 3–5ND were enrolled this cross-sectional study. Chronic Kidney Disease Epidemiology Collaboration equation...
We investigated how age affected renal function in healthy subjects Beijing and compared different estimated glomerular filtration rate (eGFR) equations. Kidney was evaluated by five equations: Chronic Disease Epidemiology Collaboration (CKD-EPI); Modification of Diet Renal Study (MDRD); the Chinese version MDRD (MDRDc); Full Age Spectrum (FAS); Berlin Initiative (BIS). A total 46,708 were enrolled followed-up for 3 years. All showed an increase sCr a reduction eGFR with increasing age. Over...
Abstract Background Bioimpedance analysis (BIA) has been reported as helpful in identifying hypervolemia. Observation data showed that hypervolemic maintenance hemodialysis (MHD) patients identified using BIA methods have higher mortality risk. However, it is not known if BIA-guided fluid management can improve MHD patients’ survival. The objectives of the BOCOMO study are to evaluate outcome guided compared with standard care. Methods This a multicenter, prospective, randomized, controlled...
Background: Renal cell carcinoma (RCC) is the most common type of malignant renal tumors with a growing incidence in recent years. This study aimed to investigate influencing factors and variation trend hospitalization expenditures among RCC patients single-centered hospital Beijing during 5 consecutive years find major cost items fluctuation tendency inpatient medical expenditures. Methods: The information Grade-A tertiary 2012–2016 was investigated main changes affecting structure. Gray...
Abstract This study aimed to use network pharmacology detail the natural components isolated from Triptergium wilfordii Hook F (TwHF) and examine effect of main component (demethylzeylasteral, DEM) on rat models diabetic nephropathy (DN). In this study, we used TwHF, referenced a gene library when screening for effective in management DN, DEM was confirmed DN rats. All data were analyzed using Discovery Studio 4.5 System systems Dock online docking method platform. 24 rats divided into 4...
ABSTRACT The development of blood-based multi-biomarker panels for screening diabetic patients, and as an easy-to-access tool identifying individuals at greatest risk developing kidney disease (DKD) its progression, is essential. However, conventional blood biomarker-based methodologies (e.g. clinical tests ELISA) are unable to predict DKD progression with high sensitivity specificity. To overcome these challenges, we developed a deep, untargeted plasma proteome profiling technology...
Background. Free light chains κ and λ (FLC κ, FLC λ) are of great significance in diagnostic monitoring monoclonal gammopathy. Freelite N-Latex methods two common at present. But the meanings not completely equivalent, especially for patients with renal insufficiency. We analyzed changes serum urine insufficiency without gammopathy clinical these changes. Methods. This study is an observational study. <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mtext>Patients</mtext>...
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The development of blood-based multi-biomarker panels for screening diabetic patients, and as an easy-to-access tool identifying individuals at greatest risk developing kidney disease (DKD) its progression, is essential. However, conventional blood biomarker-based methodologies (e.g. clinical tests ELISA) are unable to predict DKD progression with high sensitivity specificity.
Background: This study aims to investigate GFR decline in elderly subjects with varying physical conditions and analyze key risk factors impacting renal function changes. Methods: We obtained data from patients between 2017 2019, matched healthy based on gender age. Data collected for all included annual measurements of fast blood glucose (GLU), glycated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL-c), albumin (ALB), uric acid (UA), urine protein (UP), systolic pressure...
The timing of when to initiate dialysis for progressive chronic kidney disease (CKD) patients has not been well established. There a strong trend early initiation these over the past decades. However, perceived survival advantage questioned by series recent observational studies. only randomized controlled trial (RCT) research on this issue found all-cause mortality, comorbidities, and quality life showed no difference between late starters. To better understand optimal initiation, our will...
Abstract Background Older adults are more susceptible to the novel coronavirus disease 2019 (hereafter, COVID-19) and likely develop severe illness. Cytokine release syndrome (CRS) may be an important factor in development of patients with COVID-19. Interleukin-6 (IL-6) is cytokine CRS, tocilizumab can block IL-6 receptor. In this study, we analyzed therapeutic effects safety on CRS older Methods Between February 10 March 21, 2020, a total 19 or critical COVID-19 aged ≥ 60 years met study...
Multiple myeloma (MM) refers to a malignant proliferative disorder caused by abnormal proliferation of plasma cells in the bone marrow, which is characterized production monoclonal immunoglobulins or their fragments that subsequently lead damage relevant organs tissues. Renal common complication MM, and one main causes death. There are various mechanisms renal among tubular nephropathy hypercalcaemia most important. Timely effective diagnosis appropriate treatment plans can improve overall...