A5100352356- Renal Diseases and Glomerulopathies
- Gout, Hyperuricemia, Uric Acid
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Gut microbiota and health
- Gastric Cancer Management and Outcomes
- Chronic Kidney Disease and Diabetes
- Platelet Disorders and Treatments
- Antimicrobial Peptides and Activities
- Alcohol Consumption and Health Effects
- Helicobacter pylori-related gastroenterology studies
- Dialysis and Renal Disease Management
- Pharmacological Effects of Natural Compounds
- Metastasis and carcinoma case studies
- Hormonal and reproductive studies
- Colorectal Cancer Treatments and Studies
- Reproductive System and Pregnancy
- Tryptophan and brain disorders
- Probiotics and Fermented Foods
- Neurological Disease Mechanisms and Treatments
- Antimicrobial agents and applications
- Aerogels and thermal insulation
- Thyroid Cancer Diagnosis and Treatment
- Hydrogels: synthesis, properties, applications
- Gastrointestinal Tumor Research and Treatment
Qingdao University
2015-2025
Liaoning University of Traditional Chinese Medicine
2025
Shandong University of Traditional Chinese Medicine
2025
Affiliated Hospital of Qingdao University
2020-2024
Nanjing University of Chinese Medicine
2024
First Affiliated Hospital of Zhengzhou University
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2023
West China Medical Center of Sichuan University
2023
Sun Yat-sen University
2022
The goal of this study was to examine the role sodium butyrate in preserving intestinal mucosal barrier and reducing hyperuricemia (HUA).First, we established a mouse model HUA via intraperitoneal injection potassium oxonate together with yeast-rich diet detect levels serum uric acid (UA) fecal short-chain fatty acids (SCFAs). Then, vitro, different concentrations UA (NaB) were used treat LS174T Caco2 cells. effects NaB on gut determined based expression MUC2, ZO-1, Occludin.Finally, C57BL/6...
Abstract Background There is no consensus on whether triplet regimen better than doublet in the first‐line treatment of advanced gastric cancer (AGC). We aimed to compare efficacy and safety oxaliplatin plus capecitabine (XELOX) epirubicin, oxaliplatin, (EOX) regimens treating AGC. Methods This phase III trial enrolled previously untreated patients with AGC who were randomly assigned receive XELOX or EOX regimen. The primary endpoint was non‐inferiority progression‐free survival (PFS) for as...
The gut microbiota is closely linked to cholesterol metabolism-related diseases such as obesity and cardiovascular diseases. However, whether plays a causal role in cholelithiasis remains unclear.This study explored the relationship between cholelithiasis. We hypothesize that influences development.A two-sample Mendelian randomization method was combined with STRING analysis test this hypothesis. Summary data on were obtained from MiBioGen (n=13,266) FinnGen R8 consortia (n=334,367),...
Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, effect microbiome on uric acid (UA) metabolism remains unclear. This study aimed explore mechanisms through which microbiomes affect UA with hypothesis that modifying intestinal influences development hyperuricemia.We proposed combining an antibiotic strategy protein-protein interaction analysis test this hypothesis. The data demonstrated antibiotics altered composition as increased, and spectrum was connected...
Polyurethane (PU), as a thermoset polymer, is extensively utilized in various applications, such refrigerator foams, sponges, elastomers, shoes, etc. However, the recycling of post-consumed PU poses significant challenges due to its intricate and extensive crosslinking structures. Catalytic hydrogenation one most effective methods for waste, nevertheless, there currently lack catalyst that both high-performing, recyclable, cost-effective breaking down materials. This study first employs...
Abstract Current treatments for ulcerative colitis (UC) remain limited, highlighting the need novel therapeutic strategies. Trilobatin (TLB), a naturally derived food additive, exhibits potential anti‐inflammatory properties. In this study, dextran sulfate sodium (DSS)‐induced animal model is used to investigate effects of TLB on UC. It found significantly alleviates DSS‐induced UC in mice, as evidenced by reduction disease activity index, an increase colon length, improvement...
Abstract Background and Purpose Doxorubicin (DOX), an anthracycline chemotherapeutic agent, whose use is limited owing to its dose‐dependent cardiotoxicity. Mitochondrial oxidative stress plays a crucial role in the pathogenesis of DOX‐induced cardiotoxicity (DIC). Trilobatin (TLB), naturally occurring food additive, exhibits strong antioxidant properties, but cardioprotective effects DIC unclear. This study investigates effect TLB on DIC. Experimental Approach DOX was used generate vivo...
Increasing evidence highlights the critical role of Piezo1 in cardiovascular diseases, with its expression upregulated diabetic heart. However, involvement pathogenesis cardiomyopathy (DCM) remains unclear. This study aims to elucidate regulatory mitochondrial dynamics within context DCM and investigate underlying mechanisms. We constructed cardiac-specific knockout (Piezo1∆Myh6) mice. Type 1 diabetes was induced using streptozotocin (STZ) injection while type 2 established through a...
Does a defect in the human sperm-located protein prostate and testis expressed 1 (PATE1) exist both aged men young asthenozoospermia patients? A sperm PATE1 exists patients, an antibody against can decrease motility zona-free hamster oocyte penetration. Both patients have poor quality. The seems to mediate sperm–egg interactions; however, mechanisms are still unknown. This was case–control study including 60 fathers (aged 28–32 years) (68–72 years old) who donated semen by masturbation after...
Abstract The function of Latexin (LXN) in inflammation has attracted attention. However, no data are available regarding its role colitis. We report that LXN is a suppressor deficiency leads to the severity colitis DSS-induced mice, and required for therapeutic effect retinoic acid on Using proteomics approach, we demonstrate interacts forms functional complex with HECTD1 (an E3 ubiquitin ligase) ribosomal protein subunit3 (Rps3). IκBα one substrates HECTD1. Ectopic expression accumulation...
Indoleamine 2,3-dioxygenases (IDOs) degrade l-tryptophan to kynurenines and drive the de novo synthesis of nicotinamide adenine dinucleotide. Unsurprisingly, various invertebrates, vertebrates, even fungi produce IDO. In mammals, IDO1 also serves as a homeostatic regulator, modulating immune response infection via local tryptophan deprivation, active catabolite production, non-enzymatic cell signaling. Whether fungal Idos have pleiotropic functions that impact on host-fungal physiology is...
Due to the extensive use of antibiotics, many highly resistant bacteria and extensively have been produced. In recent years, increase drug-resistant resulting proliferation increased incidence hospital-acquired infections caused great harm human health. Antimicrobial peptides (AMPs) are considered be an innovative antibiotic belong latest advances in this field. We designed a polypeptide verified its low minimum inhibitory concentration broad-spectrum activity against Gram-positive bacteria,...
This study aimed to investigate the expression and cellular function of centromeric family proteins (CENPs), especially centromere protein I (CENP-I), in gastric cancer (GC) identified its clinical significance functions. CENP-I GC was studied by cDNA microarray, quantitative real-time PCR (qRT-PCR), immunohistochemistry (IHC), using datasets from The Cancer Genome Atlas (TCGA), UALCAN, Gene Expression Omnibus (GEO) databases. Microarray bioinformatic analyses upregulated...
The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is a gene that has been implicated in male reproduction. CMTM4 an evolutionarily conserved member highly expressed the testis. However, its function fertility remains unknown. Here, we demonstrate associated with spermatogenesis and sperm quality. Using Western blotting immunohistochemical analyses, found expression to be decreased poor-quality human spermatozoa, old testes, testicular biopsies...
WNT2 has been reported to be important for placental development, especially the proper vascularization of placenta. However, its precise role in first-trimester trophoblast cells is still unknown. expression villous tissues unexplained recurrent spontaneous abortion (URSA) patients was compared with that healthy women by Western blot. The function HTR-8/SVneo evaluated altering cellular level through overexpression and shRNA knockdown. molecular mechanism effect on investigated. association...
In the assisted reproduction, infertile molecules of spermatozoa from normozoospermic men who underwent unexplained failure in vitro fertilization (IVF) due to lack sperm binding normal zona pellucida, and then achieved pregnancy with rescue intracytoplasmic injection (R-ICSI) remain unclear. More works are still necessary explore this male mechanism.Normozoospermicmen IVF R-ICSI after conventional were collected. iTRAQ-based proteomic approach performed reveal new causes between men. To...
Objective The intestine is responsible for approximately one‐third of uric acid (UA) excretion. effect commensal Enterococcus faecalis ( E. ), one the most colonized bacteria in gut, on UA excretion remains to be investigated. aim this study was evaluate metabolism and gut microbiota. Methods 16S rRNA gene sequencing used examine species mouse fecal content. strain isolated from feces identified W5. hyperuricemia (HUA) animal model established with yeast‐rich forage 250 mg·kg −1 ·day...