A5100333262- Lung Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Gastric Cancer Management and Outcomes
- Kidney Stones and Urolithiasis Treatments
- Helicobacter pylori-related gastroenterology studies
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Esophageal Cancer Research and Treatment
- Sarcoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Pediatric Urology and Nephrology Studies
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- Lung Cancer Research Studies
- Advanced Radiotherapy Techniques
- Metastasis and carcinoma case studies
- Gallbladder and Bile Duct Disorders
- Total Knee Arthroplasty Outcomes
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
Fudan University
2013-2025
Tianjin Medical University Cancer Institute and Hospital
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2011-2024
Sun Yat-sen University
2011-2024
First Affiliated Hospital of Xinxiang Medical University
2024
Qingdao University
2015-2024
Yuhuangding Hospital
2022-2024
Cleveland Clinic
2014-2023
Zhongshan Hospital
2011-2023
Peking University
2009-2023
The existence of gastric cancer stem cells (CSCs) has not been definitively proven and specific cell surface markers for identifying CSCs have largely identified. Our research aimed to isolate potential clarify their clinical significance, while defining GCSC identification verification. Here, we report that spheroid possess cell-like properties, overexpress certain markers. CD133 or CD44-positive also exhibit properties CSCs. expression Oct4, Sox2, Gli1, CD44, CD133, p-AKT, p-ERK was...
Abstract Objectives Stereotactic body radiotherapy ( SBRT) is a treatment option for patients with early-stage non-small cell lung cancer (NSCLC) who are unfit surgery. Some may experience distant metastasis. This study aimed to develop and validate radiomics model predicting metastasis in NSCLC treated SBRT. Methods Patients at five institutions were enrolled this study. Radiomics features extracted based on the PET/CT images. After feature selection training set (from Tianjin), CT-based...
Abstract Background Circular RNAs (circRNAs) have been proved to play crucial roles in the development of various cancers. However, molecular mechanism circGLIS3 involved gastric cancer (GC) tumorigenesis has not elucidated. Methods The higher expression level was identified GC through RNA sequencing and subsequent tissue verification using Quantitative real-time PCR (qRT-PCR). A series functional experiments vitro vivo were performed evaluated effects on tumor growth metastasis GC....
Abstract Background There is no consensus on whether triplet regimen better than doublet in the first‐line treatment of advanced gastric cancer (AGC). We aimed to compare efficacy and safety oxaliplatin plus capecitabine (XELOX) epirubicin, oxaliplatin, (EOX) regimens treating AGC. Methods This phase III trial enrolled previously untreated patients with AGC who were randomly assigned receive XELOX or EOX regimen. The primary endpoint was non‐inferiority progression‐free survival (PFS) for as...
Abstract Gastric cancer is one of the most common malignancies. Although some patients benefit from immunotherapy, majority have unsatisfactory immunotherapy outcomes, and clinical significance immune-related genes in gastric remains unknown. We used single-sample gene set enrichment analysis (ssGSEA) method to evaluate immune cell content TCGA clustered based on scores. The Weighted Correlation Network Analysis (WGCNA) algorithm was identify subtype-related genes. were randomly divided into...
Abstract This study examines flexible interconnection technologies for medium-voltage distribution grids to improve the power supply reliability of radial lines in order meet challenges posed by high percentage new energy access and growth electric vehicle loads. The improves flexibility grid’s establishing efficient interconnections, with a particular focus on application electronics enhance operational efficiency grid. article talks about creation use boosted back-to-back voltage...
Functional elimination of p53 is a common feature large percentage human malignancies. Here, we report the development pharmacological strategy aimed at restoring function and its use for targeted therapy in p53-deficient mice. Specific inhibition deubiquitinases ubiquitin-specific peptidase 14 (USP14) resulted durable tumor regressions autochthonous lymphomas sarcomas mice without affecting normal tissues, therapeutic response was correlated with an increase ubiquitination constitutive...
Background Epigallocatechin gallate (EGCG) is a polyhydroxy phenolic compound extracted from tea and its antitumor effect has received widespread attention. We explored the inhibitory of EGCG on dimethylhydrazine (DMH)-induced colorectal cancer (CRC) using rat model, predicted interaction between CRC target genes database, explained associated pathways mechanisms in CRC. Aim To understand cell proliferation identify pharmacological targets by network pharmacology analysis. Methods DMH (40...
The global increase in total hip or knee arthroplasty has led to concern about the provision of postoperative rehabilitation. Telerehabilitation may be a strategy meet patients' requirements for rehabilitation after arthroplasty. This study aims investigate effectiveness telerehabilitation programme delivered via mobile application WeChat patients on following outcomes: self-efficacy, physical function, pain, depression, anxiety and health-related quality life.This is single-centre,...