A5065342624- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Uterine Myomas and Treatments
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Peptidase Inhibition and Analysis
- Sarcoma Diagnosis and Treatment
- Reproductive System and Pregnancy
- Metabolomics and Mass Spectrometry Studies
- Colorectal and Anal Carcinomas
- Adrenal and Paraganglionic Tumors
- Angiogenesis and VEGF in Cancer
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- interferon and immune responses
- MicroRNA in disease regulation
- Cutaneous lymphoproliferative disorders research
- Nosocomial Infections in ICU
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- SARS-CoV-2 and COVID-19 Research
The First Affiliated Hospital, Sun Yat-sen University
2023-2025
Fudan University
2006-2025
Sichuan University
2012-2025
West China Hospital of Sichuan University
2007-2025
Zhongshan Hospital of Xiamen University
2024-2025
Zhongshan Hospital
2023-2025
Sun Yat-sen University
2023-2025
Fujian Medical University
2022-2025
Union Hospital
2025
First Affiliated Hospital of Anhui Medical University
2025
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 infection, has been spreading globally. We aimed to develop a clinical model predict the outcome of patients with COVID-19 infection early.Demographic, and first laboratory findings after admission 183 (115 survivors 68 non-survivors from Sino-French New City Branch Tongji Hospital, Wuhan) were used predictive models. Machine learning approaches select features patients' outcomes. The area under...
Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been spreading globally. The number of deaths increased with the increase in infected patients. We aimed to develop a clinical model predict outcome COVID-19 patients early. Methods Epidemiological, clinical, and first laboratory findings after admission 183 (115 survivors 68 nonsurvivors) from Sino-French New City Branch Tongji Hospital were used...
Gastrointestinal (GI) fistula is a well-recognized complication of acute pancreatitis (AP). However, it has been reported in limited literature. This study aimed to evaluate the incidence and outcome GI fistulas AP patients complicated with infected pancreatic or peripancreatic necrosis (IPN). Between 2010 2013 IPN who diagnosed our center were analyzed this retrospective study. And we also conducted comparison between without regarding baseline characteristics outcomes. Over 4 years, total...
Abstract Ovarian steroid cell tumors, not otherwise specified (NOS) are rare sex cord-stromal tumors of the ovary with malignant potential. So far only a few cases were reported in English literature through Pubmed search. Here we report two such tumor, one was benign (first case underwent laparoscopic cystectomy) and other (died 10 months later after initial diagnosis), both presented amenorrhea clinical signs or symptoms virilization. In case, provided evidence (tumor embolus) addition to...
This is the first and largest prospective, multicenter, active, population-based surveillance study of epidemiology Mycoplasma pneumoniae among outpatient children with mild respiratory tract infections (RTIs) during COVID-19 pandemic. Nationwide measures like strict face mask wearing restrictions on population movement implemented to prevent spread might also effectively M. .
Abstract Among the proinflammatory mediators, platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a major primary and secondary messenger involved in intracellular extracellular communication. Evidence suggests that PAF plays significant role oncogenic transformation, tumor growth, angiogenesis, metastasis. However, PAF, with its receptor (PAFR) their downstream signaling targets, has not been thoroughly studied cancer. Here, we characterized PAFR...
PD-1 inhibitors have been routinely used to treat advanced non-small cell lung cancer (NSCLC) and significantly improved clinical outcomes. In this study, we aimed explore the influence of pretreatment fibrinogen-albumin ratio (FAR) on treatment response survival in NSCLC patients treated with first-line anti-PD-1 therapy plus platinum-based combination chemotherapy.A total 91 were included study. All received at least two cycles systemic chemotherapy. Receiver operating characteristics...
Objectives: The purpose of this study was to analyze the effect different movement strategies, embossment structures, and torque compensation aligner on tooth during arch expansion using clear aligners by finite element analysis. Methods: Models comprising maxilla, dentition, periodontal ligament, were created imported into a analysis software. tests performed following: three orders (including alternating with first premolar molar, whole second molar or premolars molar), four shapes...
Abstract The association of pseudo-Meigs' syndrome, elevation CA 125 to the struma ovarii is a rare condition. So far only nine cases have been reported in English literature through MEDLINE search. Here we report 46-year-old case ovarii, presented with ascites, hydrothorax, right ovarian mass and elevated serum level. These findings were misdiagnosed for an malignancy at first impression. Immediate resolution hydrothorax normalization level followed by removal. Struma could be cause 125....
The tumour microenvironment conferred by mesenchymal stem cells (MSCs) plays a key role in development and progression. We previously determined that platelet-activating factor receptor (PAFR) was overexpressed ovarian cancer (OCCs) PAF can promote progression via PAF/PAFR-mediated inflammatory signalling pathways. Evidence suggests MSCs secrete high concentrations of PAF. Here, we investigated the PAF/PAFR mediated OCCs its effect on progression.The culture media MSCs, co-cultured were...
Abstract Infants who are small for gestational age (SGA) at increased risk of neonatal and infant death, non-communicable diseases growth retardation. However, the epidemiological characteristics SGA remain unclear. We aim to explore prevalence examine its socioeconomic associations by using data from 21 cities. 10,515,494 single live birth records between 2014 2019 Guangdong Women Children Health Information System were included in study. Descriptive statistical methods used analyze trend...
Evaluate the clinical significance of esophagogastric junction (EGJ) morphology and contractile integral (EGJ-CI) in refractory gastroesophageal reflux disease (RGERD) patients. From June 2021 to 2023, 144 RGERD patients underwent comprehensive evaluation, recording symptom scores, demographic data. GERD classification (NERD or RE, A-D) was based on endoscopic findings. Reflux assessed through 24-hour pH-impedance monitoring, high-resolution esophageal manometry(HREM) measured parameters...
703 Background: For decades, intravesical Bacillus Calmette-Guérin (BCG) has been the standard treatment for high-risk non-muscle-invasive bladder cancer (HR NMIBC). However, its poor tolerability and limited availability underscore urgent need more effective therapies. Intravesical sequential gemcitabine docetaxel (GemDoce) demonstrated efficacy in HR NMIBC, immune checkpoint inhibitors (ICIs) have shown effectiveness as second-line therapy patients with BCG-unresponsive NMIBC....
The interpretation of proteomics data often relies on functional enrichment analysis, such as Gene Ontology (GO) enrichment, to uncover the biological functions proteins, well examination protein expression patterns across sets like Clinical Proteomic Tumor Analysis Consortium (CPTAC) database. However, conventional approaches frequently produce extensive and redundant term lists, complicating synthesis. Moreover, absence specialized tools tailored researchers limits efficient exploration...
Osteoporosis is a common disease that can lead to fracture as well various skeletal symptoms and global health problem. Traditional Chinese medicine (TCM) may offer novel approaches for treating osteoporosis. Our study aimed investigate the osteogenic potential underlying mechanisms of gastrodin in promoting differentiation. By combining network pharmacology bioinformatics, we conducted experiments inspect cell viability, Alkaline Phosphatase (ALP) Alizarin red staining (ARS) expression...
Genetic alterations, including the overexpression of epidermal growth factor receptor (EGFR), play a crucial role in ovarian carcinogenesis. To date, EGFR targeting has shown limited antitumor effects cancer when administered as monotherapy. We previously identified platelet-activating (PAFR) being overexpressed and found that its ligand PAF evoked phosphorylation. determine whether PAFR can enhance efficacy inhibition, we investigated antagonist (WEB2086) conjunction with an inhibitor...
Aim The present study aimed to assess the prevalence of potentially inappropriate medications (PIM) use in West China Hospital residents aged ≥65 years, using two sets criteria – Beers and Screening Tool Older Persons’ Prescriptions (STOPP) compare STOPP criteria, determine better for assessing PIM older adults China. Methods This was a retrospective cross‐sectional study, all patients were years admitted through Information Center from October 2010 April 2013. used identify PIM. A...