A5100406928- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Renal and related cancers
- Food composition and properties
- Endometriosis Research and Treatment
- Pluripotent Stem Cells Research
- Sperm and Testicular Function
- Wnt/β-catenin signaling in development and cancer
- TGF-β signaling in diseases
- Kruppel-like factors research
- Proteins in Food Systems
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Sirtuins and Resveratrol in Medicine
- Endoplasmic Reticulum Stress and Disease
- Histone Deacetylase Inhibitors Research
- Polysaccharides Composition and Applications
- Streptococcal Infections and Treatments
- Pregnancy and preeclampsia studies
- Aquaculture disease management and microbiota
- Fungal and yeast genetics research
- Agricultural Engineering and Mechanization
- Burn Injury Management and Outcomes
China Agricultural University
2016-2025
Beijing Obstetrics and Gynecology Hospital
2025
Hebei General Hospital
2025
Academy of State Administration of Grain
2019-2025
Capital Medical University
2009-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Affiliated Hospital of Qingdao University
2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2023
Ministry of Agriculture and Rural Affairs
2023
Ruijin Hospital
2023
Mammals have limited regenerative capacity, whereas some vertebrates, like fish and salamanders, are able to regenerate their organs efficiently. The regeneration in these species depends on cell dedifferentiation followed by proliferation. We generate a mouse model that enables the inducible expression of four Yamanaka factors (Oct-3/4, Sox2, Klf4, c-Myc, or 4F) specifically hepatocytes. Transient vivo 4F induces partial reprogramming adult hepatocytes progenitor state concomitantly...
Abstract In mammals, oocytes are arrested at the diplotene stage of meiosis I until pre-ovulatory luteinizing hormone (LH) surge triggers meiotic resumption through signals in follicular granulosa cells. this study, we show that estradiol (E2)-estrogen receptors (ERs) system cells has a dominant role controlling oocyte mammals. We found expression ERs was controlled by gonadotropins under physiological conditions. E2-ERs functional maintaining arrest regulating natriuretic peptide C and...
Foxtail millet, as a leading variety in arid and semi-arid areas of Asia Africa, can provide broad potential benefits to human health. However, its digestion properties have not been reported. So this study, the vitro starch digestibilities vivo glycemic indices (GI) foxtail millet pure products were investigated. The results showed that digestibility flour is obviously lower than wheat flour. deproteinization heating significantly increased rapidly digestible decreased slowly resistant...
Summary A major resistance quantitative trait locus, qR fg1 , significantly enhances maize to Gibberella stalk rot, a devastating disease caused by Fusarium graminearum . However, the underlying molecular mechanism remains unknown. We adopted map‐based cloning approach identify gene at and examined dynamic epigenetic changes during ‐mediated disease. CCT domain‐containing gene, Zm is causal locus polymorphic CACTA ‐like transposable element ( TE 1) c 2.4 kb upstream of genetic determinant...
Human adenoviruses (HAdVs) cause a wide range of diseases. However, the genotype diversity and epidemiological information relating to HAdVs among hospitalized children with respiratory tract infections (RTIs) is limited. Here, we describe epidemiology distribution associated RTIs in Beijing, China. Nasopharyngeal aspirates (NPA) were collected from April 2017 March 2018. detected by TaqMan-based quantitative real-time polymerase chain reaction (qPCR) assay, hexon gene was used for...
Abstract Crosstalk between oocytes and surrounding somatic cells is crucial for mammalian oogenesis, but the structural mechanisms on to control female reproduction remain unknown. Here we combine endogenous-fluorescent tracing mouse models with a high-resolution live-cell imaging system characterize oocyte-derived mushroom-like microvilli (Oo-Mvi), which mediate germ-somatic communication in mice. We perform 3D show that Oo-Mvi exhibit cellular characteristics fit an exocrine function...
Scope Heat‐treated adzuki bean protein hydrolysates (APH) reduce cholesterol in vitro. However, it is unclear if APH have anti‐obesity effects vivo and, so, the relationship between and improvement of gut microbiota composition metabolic function. Methods Results Four groups mice are fed either a normal control diet (NCD) or high‐fat (HFD) with without for 12 weeks. In HFD‐fed mice, supplementation significantly alleviate fat accumulation, dyslipidemia, insulin resistance, hepatic steatosis,...
JMJD6 is a Jumonji C domain-containing hydroxylase. binds α-ketoglutarate and iron has been characterized as either histone arginine demethylase or U2AF65 lysyl Here, we describe the structures of with without α-ketoglutarate, which revealed novel substrate binding groove two positively charged surfaces. The also contain stack aromatic residues located near active center. side chain one residue within this assumed different conformations in structures. Interestingly, bound efficiently to...
In mammalian females, progressive activation of dormant primordial follicles in adulthood is crucial for the maintenance reproductive lifespan. Misregulated leads to various ovarian diseases, such as premature insufficiency (POI). Although recent studies have revealed that several functional genes and pathways, phosphoinositide 3-kinase (PI3K) signaling, play roles controlling follicles, our understanding molecular networks regulating progress still incomplete. Here, we identify a new role...
The fabrication and applications of superhydrophobic surfaces (contact angle >150°, sliding <10°) have attracted worldwide interest with respect to materials devices. In this work, the laser-induced graphene (LIG) surface transition from pinning rolling via an extremely simple solvent treatment LIG in air is reported. By adding a certain (e.g., ethanol) surface, changes (sliding = 180°) <6°), which attributed chemically changed properties morphology LIG. Three are demonstrated developed LIG,...
In a growing follicle, the survival and maturation of oocyte largely depend on support from somatic cells to facilitate FSH-induced mutual signaling chemical communication. Although apoptosis autophagy in are involved process follicular development, underlying mechanisms require substantial study. According our study, along with antral follicles (AFs) formation, both lysine-specific demethylase 1 (LSD1) protein levels increased simultaneously granulosa (GCs) time-dependent manner, we...
Premature ovarian insufficiency (POI) is an accelerated reduction in function inducing infertility. Folliculogenesis defects have been reported to trigger POI as a consequence of ovulation failure. However, the underlying mechanisms remain unclear due genetic complexity and heterogeneity POI.
It is known that granulosa cells (GCs) mediate gonadotropin-induced oocyte meiosis resumption by releasing EGF-like factors in mammals, however, the detailed molecular mechanisms remain unclear. Here, we demonstrate luteinizing hormone (LH) surge-induced histone deacetylase 3 (HDAC3) downregulation GCs essential for maturation. Before LH surge, HDAC3 highly expressed GCs. Transcription factors, such as FOXO1, recruitment of to amphiregulin (Areg) promoter, which suppresses AREG expression....
Natural and synthetic progestogens have been commonly used to prevent recurrent pregnancy loss in women with inadequate progesterone secretion or reduced sensitivity. However, the clinical efficacy of its analogs for maintaining is variable. Additionally, underlying cause impaired endometrial responsiveness during early remains unknown. Here, we demonstrated that uterine-selective depletion BMI1, a key component polycomb repressive complex-1 (PRC1), hampers uterine derails normal...
In female mammals, the size of initially established primordial follicle (PF) pool within ovaries determines reproductive lifespan females. Interestingly, establishment PF is accompanied by a remarkable programmed oocyte loss for unclear reasons. Although apoptosis and autophagy are involved in process loss, underlying mechanisms require substantial study. Here, we identify new role lysine-specific demethylase 1 (LSD1) controlling fate oocytes perinatal mice through regulating level...
In female mammals, the majority of primordial follicles (PFs) are physiologically quiescent, and only a few them activated enter growing follicle pool. Specific molecules, such as mammalian target rapamycin (mTOR) serine/threonine kinase Akt (AKT), have been proven to be important for PF activation. However, how transcription these genes is regulated not clear. Although activators mTOR or AKT successfully used rescue fertility patients with premature ovarian insufficiency, low efficacy...
Primordial follicle pool established perinatally is a non-renewable resource which determines the female fecundity in mammals. While majority of primordial follicles maintain dormant state, only few them are activated into growing adults each cycle. Excessive activation accelerates consumption and leads to premature ovarian failure. Although previous studies including ours have emphasized importance keeping balance between dormancy via molecules within follicles, such as TGF-β, E-Cadherin,...
Premature ovarian insufficiency (POI) is a complex disease which causes amenorrhea, hypergonadotropism and infertility in patients no more than 40 years old. Recently, several studies have reported that exosomes the potential to protect function using POI-like mouse model induced by chemotherapy drugs. In this study, therapeutic of derived from human pluripotent stem cell-mesenchymal cells (hiMSC exosomes) was evaluated through cyclophosphamide (CTX)-induced model. pathological changes mice...
In mammalian ovaries, a fixed population of primordial follicles forms during the perinatal stage and oocytes contained within are arrested at dictyate meiotic prophase I. current study, we provide evidence that level cyclic AMP (cAMP) in regulates oocyte I folliculogenesis mouse ovary. Our results show early development is closely correlated with increased levels intra-oocyte cAMP. Inhibiting cAMP synthesis fetal ovaries delayed progression inhibited disassembly degradation synaptonemal...