A5109145789- Visual perception and processing mechanisms
- Neural dynamics and brain function
- PARP inhibition in cancer therapy
- Biomedical Text Mining and Ontologies
- Neurobiology and Insect Physiology Research
- DNA Repair Mechanisms
- Bioinformatics and Genomic Networks
- Retinal Development and Disorders
- Advanced Proteomics Techniques and Applications
- Computational Drug Discovery Methods
Sichuan University
2010-2025
West China Hospital of Sichuan University
2024-2025
Regenerative Medicine Institute
2025
Clinical Research Management
2025
Abstract In light of anatomical evidence suggesting differential connection patterns in central vs. peripheral representations cortical areas, we investigated the extent to which response properties cells primary visual area (V1) marmoset change as a function eccentricity. Responses combinations spatial and temporal frequencies stimuli were quantified for neurons with receptive fields ranging from 3° 70° Optimal stimulus speeds reflected expectation that responses throughout V1 are...
The interpretation of proteomics data often relies on functional enrichment analysis, such as Gene Ontology (GO) enrichment, to uncover the biological functions proteins, well examination protein expression patterns across sets like Clinical Proteomic Tumor Analysis Consortium (CPTAC) database. However, conventional approaches frequently produce extensive and redundant term lists, complicating synthesis. Moreover, absence specialized tools tailored researchers limits efficient exploration...
Cisplatin is one of the most commonly used chemotherapy drugs for treating solid tumors. As a genotoxic agent, cisplatin binds to DNA and forms platinum-DNA adducts that cause damage activate series signaling pathways mediated by various DNA-binding proteins (DBPs), ultimately leading cell death. Therefore, DBPs play crucial roles in cellular response determining fate. However, systematic studies responding their temporal dynamics are still lacking. To address this, we developed novel...
The physiological characteristics of the marmoset second visual area (V2) are poorly understood compared with those primary (V1). In this study, we observed response V2 neurons in four healthy adult marmosets using intracortical tungsten microelectrodes. We recorded 110 V2, receptive fields located between 8° and 15° eccentricity. Most (88.2%) these were orientation selective, half-bandwidths typically ranging 10° 30°. A significant proportion (28.2%) direction selectivity had a index...