A5100654003- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- Regulation of Appetite and Obesity
- Gout, Hyperuricemia, Uric Acid
- Gut microbiota and health
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Screening and Detection
- Alcohol Consumption and Health Effects
- Microscopic Colitis
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Galectins and Cancer Biology
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- Clinical Nutrition and Gastroenterology
- Biochemical Analysis and Sensing Techniques
- Cancer Immunotherapy and Biomarkers
- Diet and metabolism studies
- Cytomegalovirus and herpesvirus research
- Ferroptosis and cancer prognosis
Qingdao University
2012-2023
Affiliated Hospital of Qingdao University
2010-2023
Inner Mongolia University of Science and Technology
2023
Baotou Medical College
2023
Université de Montréal
2017
McGill University
2017
Haier Group (China)
2008
IBM Watson for Oncology (WFO), which can use natural language processing to evaluate data in structured and unstructured formats, has begun be used China. It provides physicians with evidence-based treatment options ranks them three categories decision support. This study was designed examine the concordance between recommendation proposed by WFO actual clinical decisions oncologists our cancer center, would reflect differences of China U.S.Retrospective from 362 patients were ingested into...
The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia. loss humans during primate evolution causes their vulnerability to Thus, we generated a Uox-knockout model on pure C57BL/6J background using transcription activator-like effector nuclease (TALEN) technique. These mice spontaneously developed hyperuricemia (over 420 μmol/l) with about 40% survival up 62 weeks. Renal...
Previous studies have demonstrated the effects of hyperuricemia on damage to target organs, including kidneys, joints and heart. However, it is unclear whether results in intestines. The aim present study was investigate intestinal barrier dysfunction a mouse model constructed by knocking out urate oxidase (Uox) gene. morphology intestine assessed via hematoxylin eosin, alcian blue staining. serum tissue levels uric acid, tumor necrosis factor (TNF)‑α interleukin (IL)‑6, addition presence...
The goal of this study was to examine the role sodium butyrate in preserving intestinal mucosal barrier and reducing hyperuricemia (HUA).First, we established a mouse model HUA via intraperitoneal injection potassium oxonate together with yeast-rich diet detect levels serum uric acid (UA) fecal short-chain fatty acids (SCFAs). Then, vitro, different concentrations UA (NaB) were used treat LS174T Caco2 cells. effects NaB on gut determined based expression MUC2, ZO-1, Occludin.Finally, C57BL/6...
Alterations in the microbiome are associated with development of gastric cancer. Our study aimed to identify dysbiotic features early The was assessed cancer (n = 30), advanced 30) and chronic gastritis 60). results demonstrated significant differences microbial profile composition between cancer, suggesting alterations progression. Linear discriminant analysis effect size (LEfSe) analyses identified 32 bacterial genera that were Functional showed production urease synthesis flagella...
Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, effect microbiome on uric acid (UA) metabolism remains unclear. This study aimed explore mechanisms through which microbiomes affect UA with hypothesis that modifying intestinal influences development hyperuricemia.We proposed combining an antibiotic strategy protein-protein interaction analysis test this hypothesis. The data demonstrated antibiotics altered composition as increased, and spectrum was connected...
Endoscopic submucosal dissection (ESD) has been routinely performed in applicable early gastric cancer (EGC) patients as an alternative to conventional surgical operations that involve lymph node dissection. The indications for ESD have recently expanded include larger, ulcerated, and undifferentiated mucosal lesions, differentiated lesions with slight invasion. risk of metastasis (LNM) is the most important consideration when deciding on a treatment strategy EGC. Despite advantages over...
The aim of this study is to identify and consolidate reliable endoscopic features associated with H. pylori infection in gastric mucosa, which one the major causes cancer. A total 256 Chinese patients symptomatic stomach disturbances were enrolled. Pathological examination was conducted using a light microscope biopsy specimens stained hematoxylin-eosin. Endoscopic performed high resolution video endoscope. association between pathological diagnosis compared, significantly identified. 14...
Ulcerative colitis (UC) is considered an immune-mediated disease. The disorder of T-lymphocyte subsets plays important role in the pathogenesis UC. aim this study was to evaluate significance peripheral blood assessing disease severity and predicting clinical outcomes UC patients.The retrospective case-control performed 116 patients with active 90 healthy controls (HC). included were followed up for 180 days. Analyses t-test, Spearman's correlation coefficient, multivariable Cox regression...
Intestinal flora performs a crucial role in human health and its imbalance may cause numerous pathological changes. The liver can also affect the intestinal function through bile secretion via enterohepatic cycle. pathophysiological association between gut is described as gut‑liver axis. present study investigated of alcohol‑induced fibrosis. A total 36 C57 mice were randomly equally divided into 3 different dietary regimes: Group I (alcohol injury; received alcohol); group II injury with...
BACKGROUND:This study investigated the molecular mechanism of effect CD44 on recurrence EGC after ESD, including potential regulator and signaling pathways CD44. MATERIAL AND METHODS:We searched miRNA online database (www.mirdb.org) with "seed sequence" located within 3'-UTR target gene, performed luciferase assay to test miRNA/mRNA relationship. We also determined expression in control samples. In addition, statistical analysis was used explore role miR-328 as a biomarker predict ECD....
Abstract Background When the risk of lymph node metastasis (LNM) is considered minimal in patients with early gastric cancer (EGC), endoscopic submucosal dissection (ESD) an effective alternative to radical resection. This study aims estimate feasibility ESD for EGC ulceration. Patients and Methods We retrospectively reviewed data from 691 who underwent gastrectomy Subsequently, a stratification system lesions was created based on expanded criteria, associations between subgroups rate LNM...
Background: Endoscopy plays an important role in the management of acute variceal bleeding (AVB) patients with cirrhosis. This study aimed at determining optimal endoscopy timing for cirrhotic AVB. Methods: Patients cirrhosis AVB across 34 university hospitals 30 cities from February 2013 to May 2020 who underwent within 24 hours were included this study. divided into urgent group (endoscopy <6 h after admission) and early 6–24 admission). Multivariable analysis was performed identify...
Chrysin (CHR) is a flavonoid with extensive pharmacological activity. The molecular formula of CHR C15 H10 O4 . reported to have antioxidative, antitumour and antiviral functions. To evaluate its potential function as vaccine adjuvant, we prepared melanoma using soluble protein extract B16F10 cells antigen an adjuvant. model was developed after two immunizations, it discovered that combining antigen-mixed could inhibit tumour growth in the mouse model, overall survival rate higher than...
AIM:To determine the expression levels of gastrointestinal nesfatin-1 in ventromedial hypothalamic nucleus (VMH)-lesioned (obese) and ventrolateral (VLH)-lesioned (lean) rats that exhibit an imbalance their energy metabolism gastric mobility. METHODS:Male Wistar were randomly divided into a VMH-lesioned group, VLH-lesioned respective sham-operated groups.The animals had free access to food water, diets weights monitored after surgery.Reverse transcription-polymerase chain reaction...
Helicobacter suis has a greater tendency to induce gastric mucosa-associated lymphoid tissue lymphoma compared with other species in humans and animals. Saccharomyces boulardii been established as an adjunct H. pylori eradication treatment, but the effect of S. administration alone on infection remains unclear. Here, we found that effectively decreased bacterial load inhibited formation follicles stomach post-infection. The levels suis-specific immunoglobulin A (IgA) secretory IgA juice...
Abstract Background The significance of endoscopic evaluation in the diagnosis and management ulcerative colitis (UC) has been widely recognized. Over years, scholars have established several scores. Herein, we assessed clinical application value Mayo Endoscopic Subscore (Mayo ES), Degree Ulcerative Colitis Burden Luminal Inflammation (DUBLIN) score, Index Severity (UCEIS) score UC patients, by comparing their correlation with disease activity predictive potential for treatment response...