A5032430749- Gout, Hyperuricemia, Uric Acid
- Immunotherapy and Immune Responses
- Case Reports on Hematomas
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Hepatitis B Virus Studies
- Pancreatic function and diabetes
- Cell Adhesion Molecules Research
- Liver physiology and pathology
- Mesenchymal stem cell research
- Esophageal Cancer Research and Treatment
- Nitric Oxide and Endothelin Effects
- Alcohol Consumption and Health Effects
- Traditional Chinese Medicine Studies
- Eosinophilic Disorders and Syndromes
- Lipid metabolism and disorders
- Hepatitis C virus research
- Diabetes and associated disorders
- Inflammasome and immune disorders
- Radiomics and Machine Learning in Medical Imaging
- Diabetes Management and Research
- Diabetes Management and Education
- Dermatologic Treatments and Research
- Parathyroid Disorders and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Hefei Institutes of Physical Science
2023-2024
Chinese Academy of Sciences
2021-2024
Qingdao University
2013-2023
Affiliated Hospital of Qingdao University
2014-2023
Shihezi University
2018-2019
Fudan University
2006-2016
Ministry of Education of the People's Republic of China
2011
Zhongshan Hospital
2006-2010
The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia. loss humans during primate evolution causes their vulnerability to Thus, we generated a Uox-knockout model on pure C57BL/6J background using transcription activator-like effector nuclease (TALEN) technique. These mice spontaneously developed hyperuricemia (over 420 μmol/l) with about 40% survival up 62 weeks. Renal...
Abstract Purpose: Hepatocellular carcinoma (HCC) is an aggressive malignancy and a devastating clinical complication of chronic liver disease. Therapeutic options are limited mainly because the genetic biochemical understanding this disease remains fragmented. We intended to study role signal transducer activator transcription 3 (STAT3) aberrant signaling in HCC malignancy, therapeutic potential inhibition STAT3 expression for HCC. Experimental Design: A 2′-O-methoxyethylribose–modified...
The effects and possible mechanisms of adipose-derived stem cells (ASC) infusion on type 2 diabetic rats were investigated in this study. Twenty normal male Sprague-Dawley included control group, 40 randomly divided into group ASC (which received infusion). After therapy, levels fasting plasma glucose (FPG), HbA1c, serum insulin C-peptide, recovery islet cells, inflammatory cytokines, sensitivity analyzed. infusion, compared with hyperglycemia was ameliorated weeks maintained for about 6...
Low doses of febuxostat or benzbromarone are widely used in Asian countries, but lacking studies to compare the efficacy and safety two urate-lowering drugs. To low-dose with patients primary gout, a randomized controlled, open-label trial was performed among male gout for therapy (ULT) dedicated clinic China. Randomization carried out by third-party institution according random number table. Patients were randomly assigned 1:1 group (Feb group) (20 mg daily) (Ben (25 treated 12 weeks....
Recent evidence indicates that tetraspanin-8 (TSPAN8) promotes tumor progression and metastasis. In this study, we explored the effects of TSPAN8 molecular mechanisms underlying hepatocellular carcinoma (HCC) metastasis using various HCC cell lines, tissues from 149 patients, animal models progression. We showed elevated expression promoted invasion in vitro vivo, but did not influence proliferation vitro. Increased human was predictive poor survival, multivariate analyses indicated to be an...
CXCR7, a recently identified chemokine receptor, has been implicated in directing cancer metastasis. In the present study, potential roles of CXCR7 growth and metastasis hepatocellular carcinoma (HCC) were evaluated. A receptor gene chip was used to compare expression HCC cell lines with different metastatic potential. Effects targeting by RNA interference (RNAi) on proliferation HCCLM3 cells observed vitro vivo. 116 specimens from patients or without assessed tissue microarray. As result,...
Radical concurrent chemoradiotherapy (CCRT) is frequently used as the first-line treatment for patients with locally advanced esophageal cancer. Unfortunately, some respond poorly. To predict response to radical in pre-treatment squamous carcinoma (ESCC), and compare predicting efficacies of radiomics features primary tumor or without regional lymph nodes, we developed a radiomics-clinical model based on positioning CT images. Finally, SHapley Additive exPlanation (SHAP) was explain...
Urate-lowering treatment (ULT) is recommended in gout management. However, initiation of ULT during an acute flare still inconclusive. This study aimed to evaluate the efficacy and safety febuxostat administered at attack.A prospective randomized controlled clinical trial was conducted for 12 weeks primary patients who were admitted with attacks. Subjects randomly assigned group which febuxostat, 40mg daily, care setting attacks, or control after All received adequate anti-inflammatory...
To determine whether steroidogenic enzyme expression is associated with the steroid secretory pattern of subclinical Cushing's syndrome (SCS) by investigating mRNA and protein CYP17 CYP11B1 in SCS adenomas, normal adrenal cortices (NA), non-functional adenomas (NFA) cortisol-producing (CPA).Total RNA were extracted from 20 CPA, six SCS, 15 NFA, eight NA. Real-time quantitative polymerase chain reaction (PCR) western blotting analysis performed to different tissues. The adrenocortical tumors...
Serum uric acid is reportedly associated with thrombosis development. However, still unclear the mechanism of high in involvement let-7c. In an aim to fill this void, we conducted study by treating mice and human umbilical vein endothelial cells acid. Analysis indicated that let-7c was upregulated hyperuricemia patients as well treated Furthermore, inhibited myocyte enhancer factor-2C, but activated nuclear factor-kappa B pathway cells. Then targeting relationship between factor-2C verified....
Abstract Objectives To compare the efficacy and safety of citrate mixture sodium bicarbonate on urine alkalization in gout patients under benzbromarone treatment. Methods A prospective, randomized, parallel controlled trial was conducted among 200 dedicated clinic Affiliated Hospital Qingdao University. The participants were randomly divided into two groups (1:1), group (3 g/day) (7 g/day). All prescribed with 25 mg/day at initiation maintained a dose 50 mg/day. Clinical biochemical data...
Abstract Background While xanthine oxidase inhibitors target uric acid production, renal urate underexcretion is the predominant subtypes in gout. This study was to compare treatment response XOI febuxostat a gout cohort according clinical of hyperuricemia. Methods A prospective conducted efficacy and safety (initially 20 mg daily, escalating 40 daily if not at target) 644 patients with three major for 12 weeks. Hyperuricemia defined as overload subtype, or combined subtype based on UUE >...
Aims. To examine the potential differences between multiple daily injection (MDI) regimens based on new long-acting insulin analogues (glargine or detemir) plus prandial aspart and continuous subcutaneous infusion (CSII) in patients with poorly controlled type 2 diabetes. Methods. Patients (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">119</mml:mn></mml:math>) diabetes of a duration exceeding five years were...
Hypertension is a cardiovascular disease that seriously affects human health. Activation of the calcium-sensing receptor (CaSR) inhibits cyclic adenosine monophosphate (cAMP) formation by increasing [Ca2+]i and subsequently inhibiting renin release. The renin-angiotensin system (RAS) plays an important role in development essential hypertension (EH). purpose this study was to determine effects NPSR568 (R568)-activated CaSR on blood pressure (BP), proliferation, remodeling vascular smooth...
Hypertension is a cardiovascular disease that severely impairs human health; however, its specific etiology and pathogenesis are complex. The present study investigated the effects of calcium sensing receptor (CaSR) on vascular tone in spontaneously hypertensive rats (SHRs), clarified role mechanism CaSR regulating this property with respect to phospholipase C (PLC)‑inositol 1,4,5‑triphosphate (IP3)/adenylate cyclase‑V(AC‑V)/cyclic adenosine monophosphate (cAMP)/renin‑angiotensin system...