A5013409818- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Case Reports on Hematomas
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Marine Bivalve and Aquaculture Studies
- Animal Genetics and Reproduction
- Diet, Metabolism, and Disease
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Eosinophilic Disorders and Syndromes
- Aquaculture Nutrition and Growth
- Genital Health and Disease
- Liver Disease and Transplantation
- Pharmacological Effects of Natural Compounds
- Pancreatitis Pathology and Treatment
- Microplastics and Plastic Pollution
- RNA modifications and cancer
- Muscle and Compartmental Disorders
- Bartonella species infections research
- Marine Biology and Environmental Chemistry
- Marine Ecology and Invasive Species
- Musculoskeletal synovial abnormalities and treatments
- Physiological and biochemical adaptations
- Parasite Biology and Host Interactions
Qingdao University
2019-2025
Affiliated Hospital of Qingdao University
2019-2025
Ocean University of China
2017
Clinical studies have shown a link between hyperuricemia (HU) and diabetes, while the exact effect of soluble serum urate on glucose metabolism remains elusive. This study aims to characterize metabolic phenotypes investigate underlying molecular mechanisms using novel spontaneous HU mouse model in which uricase (Uox) gene is absent. In an attempt role glycometabolism, we implemented external stimulation Uox knockout (KO) wild-type (WT) males with high-fat diet (HFD) and/or injections...
Objective The predominant mechanism driving hyperuricemia in gout is renal uric acid underexcretion; however, the standard urate‐lowering therapy (ULT) recommendation first‐line xanthine oxidase inhibitor (XOI), irrespective of cause hyperuricemia. This comparative effectiveness clinical trial was undertaken to compare nontitrated low‐dose benzbromarone (LDBen) uricosuric XOI ULT with febuxostat (LDFeb) patients underexcretion. Methods We conducted a prospective, randomized, single‐center,...
Abstract Background Patients with gout frequently have low urinary pH, which is associated the nephrolithiasis. However, specific distribution of pH and potential relationship acidic urine to broader manifestations kidney disease in are still poorly understood. Methods A 2016–2020 population-based cross-sectional study was conducted among 3565 patients dedicated clinic Affiliated Hospital Qingdao University investigate association between disease. We studied that we defined “primary gout”,...
Objective: Extrachromosomal circular DNA elements (eccDNAs) are known for their broad existence in cells and plasma, which may potentially play important roles many biological processes. Our aim was to identify functional or marked eccDNAs gout patients. Methods: The Circle-Seq approach applied eccDNA detection from plasma acute patients healthy controls. Further analysis performed on the distribution of genomic gene annotations two groups. Results: We detected 57,216 109,683 control...
Abstract Objectives Gout patients frequently have decreased urine pH, related to metabolic syndrome (MetS) and chronic kidney disease. Here, we aimed investigate whether the addition of alkalization urate-lowering therapy (ULT) is associated with improvements in albuminuria, gout flares or MetS outcomes men low urinary pH (pH < 6.2). Methods A prospective cohort study enrolled 385 participants starting ULT febuxostat (initially 20 mg daily, escalated 40 daily if serum urate ≥360...
Low doses of febuxostat or benzbromarone are widely used in Asian countries, but lacking studies to compare the efficacy and safety two urate-lowering drugs. To low-dose with patients primary gout, a randomized controlled, open-label trial was performed among male gout for therapy (ULT) dedicated clinic China. Randomization carried out by third-party institution according random number table. Patients were randomly assigned 1:1 group (Feb group) (20 mg daily) (Ben (25 treated 12 weeks....
Low urine pH, which may be mediated by metabolic syndrome (MetS), is common in gout. Tart cherries are shown to improve MetS symptoms and possess anti-inflammatory properties. However, the efficacy of tart cherry supplements on pH has yet studied.This study aimed investigate safety supplementary citrate (TaCCi) mixture serum urate (sUA), C-reactive protein (CRP), gout flares patients initiating urate-lowering therapy (ULT), comparison sodium bicarbonate.A prospective, randomized (1:1:1),...
Abstract Background The prevalence of hyperuricemia is increasing in adults, while the among adolescents seldom reported. Methods A cross-sectional survey by multistage, stratified sampling method was carried out Shandong Province during 2017–2018. total 9371 aged from 13 to 19 years were randomly sampled and analyzed this survey. Results overall mean serum uric acid (sUA) concentration 6.08 ± 1.57 mg/dL 25.4% 60.5% (when defined as sUA ≥ 7 or 5.5 mg/dL). Prevalence 42.3% (male) 8.0%...
Hyperuricemia can be stratified into four subtypes according to renal uric acid handling. The aim of this study was comprehensively describe the biologic characteristics (including genetic background) clinically defined hyperuricemia in two large geographically independent gout cohorts.
Objective Mechanisms underlying the adolescent‐onset and early‐onset gout are unclear. This study aimed to discover variants associated with gout. Methods We conducted whole‐genome sequencing in a discovery cohort of 905 individuals (gout onset 12 19 years) common low‐frequency single‐nucleotide (SNVs) Candidate SNVs were genotyped an 2,834 ≤30 years old), meta‐analysis was performed replication cohorts identify loci Transcriptome epigenomic analyses, quantitative real‐time polymerase chain...
Abstract Objectives The objective of this study was to develop and validate a prediction model for renal urate underexcretion (RUE) in male gout patients. Methods Men with enrolled from multicenter cohorts China were analyzed as the development validation data sets. RUE phenotype defined fractional excretion uric acid (FE UA ) <5.5%. Candidate genetic clinical features screened by least absolute shrinkage selection operator (LASSO) 10-fold cross-validation. Machine learning algorithms...
Achieving a goal of serum urate levels in patients with gout is an important way to prevent and its complications while it remains difficult low targeting rate worldwidely. Currently, hyperuricemia classification has not been widely applied the management owing insufficient clinical evidences. This study aimed evaluate effectiveness achieving target based on Chinese gout. In this prospective study, receiving lowering therapy benzbromarone were assigned two groups, renal underexcretion...
Piwi (P-element induced wimpy testis) is an important gene involved in stem cell maintenance and gametogenesis vertebrates. However, most invertebrates, especially mollusks, the function of during remains largely unclear. To further understand gametogenesis, full-length cDNA Piwi1 from scallop Chlamys farreri (Cf-Piwi1) was characterized, which consisted a 2,637 bp open reading frame encoding 878-amino acid protein. Cf-Piwi1 mRNA mainly localized spermatogonia, spermatocytes, oogonia,...
Abstract Objectives To compare the efficacy and safety of citrate mixture sodium bicarbonate on urine alkalization in gout patients under benzbromarone treatment. Methods A prospective, randomized, parallel controlled trial was conducted among 200 dedicated clinic Affiliated Hospital Qingdao University. The participants were randomly divided into two groups (1:1), group (3 g/day) (7 g/day). All prescribed with 25 mg/day at initiation maintained a dose 50 mg/day. Clinical biochemical data...
Objective The Māori and Pacific (Polynesian) population of Aotearoa New Zealand has a high prevalence gout. Our aim was to identify potentially functional missense genetic variants in candidate inflammatory genes amplified frequency that may underlie the increased gout Polynesian populations. Methods A list 712 disease-related generated. An silico targeted exome set extracted from whole genome sequencing data people with various ancestral groups (Polynesian, European, East Asian; n = 55,...
Abstract Gout is a chronic disease of monosodium urate crystal deposition in the setting hyperuricemia that typically presents with recurrent flares acute inflammatory arthritis occur due to innate immune response deposited crystals. The molecular mechanism progression from clinical gout poorly understood. Here we provide insights into this genetic study 2.6 million people, including 120,282 people gout. We detected 376 loci and 410 genetically independent signals (148 new gout). identified...
Abstract Objective Oxylipins modulate inflammation via complex pathways. The oxylipin profile in gout remains unexplored. In this study, we systemically profiled oxylipins young men and identified new biomarkers for clinical use differentiating from hyperuricaemia. Material methods Oxylipin profiling was performed 90 (30 very early onset gout, 30 asymptomatic hyperuricaemia [HU] normouricaemia [NU], all aged &lt;20 years) divided into discovery validation sample sets. dataset analysed...
Objective To clarify the relationship between serum urate (SU) decrease and visceral fat area (VFA) reduction in patients with gout. Methods We retrospectively analyzed 237 male gout who had two sets of body composition metabolic measurements within 6 months. Subjects included all been treated urate-lowering therapy (ULT) (febuxostat 20–80 mg/day or benzbromarone 25–50 mg/day, validated by medical record). All were from specialty clinic The Affiliated Hospital Qingdao University. multiple...
Abstract Objective Gout flares during urate-lowering therapy (ULT) initiation are common, but predictors of these poorly understood. The aim this study was to determine whether serum CA72-4 is an independent predictor for gout ULT initiation. Methods A prospective cohort conducted between March 2021 and January 2022. Men with gout, at least one flare in the past year, three measurements previous six months were enrolled. Participants grouped according their highest recorded levels (above or...
Abstract Urate in the fingernails of gout patients and healthy volunteers was successfully detected by high-performance liquid chromatography (HPLC) with ultraviolet (UV) our previous research. This study aimed to further investigate whether nail urate could be a proxy for burden monosodium (MSU) crystals deposits gout. To this end, we conducted two parts. Firstly, HPLC–UV evaluated concentrations control subjects As expected, found that levels were significantly higher than controls, level...