A5100451964- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- Pharmacological Effects and Toxicity Studies
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Neurogenesis and neuroplasticity mechanisms
- Autoimmune Neurological Disorders and Treatments
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Axon Guidance and Neuronal Signaling
- Gout, Hyperuricemia, Uric Acid
- RNA regulation and disease
- Cellular transport and secretion
- Nuclear Receptors and Signaling
- Nicotinic Acetylcholine Receptors Study
- Alzheimer's disease research and treatments
- Drug Transport and Resistance Mechanisms
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- MicroRNA in disease regulation
- Hedgehog Signaling Pathway Studies
- Functional Brain Connectivity Studies
- Neurological Complications and Syndromes
- Case Reports on Hematomas
South China Agricultural University
2025
Affiliated Hospital of Qingdao University
2019-2025
Qingdao University
2019-2025
Chongqing Medical University
2015-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2024
Qiqihar Medical University
2024
Fourth Affiliated Hospital of Harbin Medical University
2007-2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2012-2024
Tongji University
2024
Arsenite exposure is known to increase the risk of neurological disorders via alteration dopamine content, but detailed molecular mechanisms remain largely unknown. In this study, using both dopaminergic neurons PC-12 cell line and C57BL/6J mice as in vitro vivo models, our results demonstrated that 6 months arsenite drinking water caused significant learning memory impairment, anxiety-like behavior alterations conditioned avoidance escape responses male adult mice. We also were first reveal...
As patients with Parkinson's disease (PD) are at high risk for comorbid depression, it is hypothesized that these two diseases sharing common pathogenic pathways. Using regional homogeneity (ReHo) and functional connectivity approaches, we characterized human brain activity resting state to examine specific networks in PD those depression (PDD). This study comprised 41 25 normal subjects. The completed the Hamilton Depression Rating Scale were further divided into groups: depressive symptoms...
Abstract Background Stroke represents the second most prevalent contributor to global mortality. The Chinese Visceral Adiposity Index (CVAI) serves as an established metric for assessing visceral adiposity in population, exhibiting prognostic capabilities. This investigation aimed explore association of CVAI and new-onset stroke among middle-aged older populations. Methods study employed data from 2011 2018 China Health Retirement Longitudinal Study (CHARLS) assess incidence stroke....
Oxytetracycline (OTC) is a broad-spectrum antibiotic commercially produced by Streptomyces rimosus. Despite its importance, little known about the regulation of OTC biosynthesis, which hampered any effort to improve production via engineering regulatory genes.A gene encoding protein (SARP) was discovered immediately adjacent otrB oxy cluster in S. rimosus and designated otcR. Deletion complementation otcR abolished or restored production, respectively, indicating that encodes an essential...
GPR40 modulates epileptic seizure and NMDA receptor function through the regulation of NR2A NR2B surface expression.
MMP13 (matrix metallopeptidase 13) plays a key role in bone metabolism and cancer development, but has no known functions Alzheimer's disease. In this study, we used high-throughput small molecule screening SH-SY5Y cells that stably expressed luciferase reporter gene driven by the BACE1 (β-site amyloid precursor protein cleaving enzyme 1) promoter, which included portion of 5' untranslated region (5'UTR). We identified CL82198, selective inhibitor MMP13, decreased levels cultured neuronal...
Abstract Background Intramuscular fat is an important factor in evaluating pork quality and varies widely among different pig breeds. However, the regulatory mechanism of circular RNAs (circRNAs) lipid metabolism remains largely unexplored. Results We combined circRNA-seq Ribo-seq data to screen a total 18 circRNA candidates with coding potential, circANKRD17 was found be significantly elevated longissimus dorsi muscle Lantang piglets, length 1,844 nucleotides. Using single-cell sequencing,...