A5077235896- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- High Altitude and Hypoxia
- Cerebrovascular and genetic disorders
- Ophthalmology and Eye Disorders
- Intraocular Surgery and Lenses
- Moyamoya disease diagnosis and treatment
- Lysosomal Storage Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Metabolism and Genetic Disorders
- Adenosine and Purinergic Signaling
- Ocular Diseases and Behçet’s Syndrome
- melanin and skin pigmentation
- Ocular Infections and Treatments
- Nasolacrimal Duct Obstruction Treatments
- Retinal Development and Disorders
- RNA regulation and disease
- Cell Adhesion Molecules Research
- Seaweed-derived Bioactive Compounds
- Microencapsulation and Drying Processes
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
Peking University First Hospital
2015-2025
Peking University
2015-2025
First Affiliated Hospital of Xi'an Jiaotong University
2024
Zhejiang University
2021
Zhejiang University of Science and Technology
2011
The Affiliated Yongchuan Hospital of Chongqing Medical University
2011
Chongqing Medical University
2011
Guangxi Medical University
2011
George Institute for Global Health
2009
Ophthalmology Associates (United States)
2008
To compare, in vivo, differences meibomian gland morphology between children and adolescents.Sixty-nine patients were included this study divided into two groups: (n = 31; age range: 3 to 11 years) adolescents 39; 12 18 years). Images of glands obtained by infrared meibography analyzed using ImageJ software (developed the National Institutes Health; available at http://rsb.info.nih.gov/ij/download.html). Meibomian loss, number ducts, relative width percent area acini compared...
Objectives . The objective of the study is to observe changes in choroidal thickness (CT) patients with Graves’ ophthalmopathy using spectral-domain optical coherence tomography (SD-OCT). Methods right eyes 36 (27 females and 9 males) (GO) those age-, gender-, diopter-level-matched healthy participants were evaluated. patients’ data obtained within 3 months after onset disease (GD). Thyroid hormone levels thyroid-stimulating receptor antibody (TRAb) measured, degree exophthalmos was measured...
Abstract Purpose The aim of this study was to assess retinal microvascular parameters (RMPs) in Fabry disease (FD) using deep learning, and analyze the correlation with brain lesions related cerebral small vessel (CSVD). Methods In retrospective case control study, fundus images from 27 FD patients age- sex-matched healthy subjects were collected. RMPs, encompassing diameter, density, symmetry, bifurcation, tortuosity, quantified. Laboratory examination results, Mainz severity score index...
To investigate use of collagenase type II for generating a rabbit model corneal ectasia.Ten New Zealand white rabbits were used with right eyes treated as the experimental group and left control group. After epithelial debridement, solution (200 μL 5 mg/mL) was applied in at room temperature (24 °C) 30 min, 200 without Slit-lamp microscopy, mean keratometry (Km), central cornea thickness (CCT) examined before after procedure. Corneas obtained on day 14 biomechanical evaluation.No obvious...
Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in (ADA2), has not been systemically investigated Chinese population yet. We aim to further characterize DADA2 cases China.A retrospective analysis patients with identified through whole exome sequencing (WES) at seventeen rheumatology centers across China was conducted. Clinical characteristics, laboratory findings, genotype, and treatment response were...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small artery disease caused by NOTCH3 gene mutation. We performed enhanced depth imaging optical coherence tomography (EDI-OCT) to evaluate the retinal vessel changes in CADASIL patients assessed their consonance brain magnetic resonance (MRI) findings.Of 27 genetically confirmed an equal number of controls were recruited at Peking University First Hospital from January 2015...
Aim To evaluate the efficacy of anti-seizure medications (ASMs), quinidine, and ketogenic diet therapy (KDT) for KCNT1 -related epilepsy to explore genotype-efficacy correlations. Methods We collected data cases from our hospital's medical records literature. In total, 50 patients received 23 classical KDT, 15 ASMs; all ASM were hospital owing lack detailed in The rates (ERs) treatments compared; an ER that reduced number seizures by ≥50% was considered positive. Efficacy according genotype...
The long-acting insulin analogue degludec (IDeg) is increasingly recommended for type two diabetes (T2DM), yet clinical experience in China remains limited. This retrospective study aimed to delineate the initiation strategy IDeg Chinese hospitalized patients with T2DM.
To evaluate the biomechanical efficacy and safety of in vivo microbial transglutaminase (Tgases)-induced corneal crosslinking a rabbit model.A total 34 white New Zealand rabbits were divided into two groups, biochemistry group photochemistry group. The right eye every was treated left eyes served as negative controls. In group, 1 U/mL solution agent Tgases (Tgases CXL) applied to surface, while clinical ultraviolet A-riboflavin (UVA/RF used. Efficacy evaluated on 14th day after procedures....
To investigate ocular abnormalities in Fabry disease (FD).Forty-five patients with FD diagnosed by genetic analysis were enrolled a single medical centre. The following examinations performed: slit-lamp examination, ophthalmic fundus imaging, vivo confocal microscopy (IVCM) and optical coherence tomography (OCT). prevalences of typical the cornea, conjunctiva retina recorded; their differences between hemizygote heterozygote compared.In this study, prevalence corneal verticillata was 97.8%...
Purpose To investigate changes in intraocular pressure (IOP) and axial length (AL) on the ascent to high altitude from Beijing Lhasa. Patients methods Twenty volunteers (17 men, 3 women) who had been sent work Lhasa, Tibet for more than 6 months were enrolled. One of their journeys Lhasa was chosen as time examination. IOP, AL, corneal curvature (K), blood (BP) measured (altitude 43 m) 3658 m). Their first examination conducted at least 1 day before arriving second after they stayed 7 days....
<b><i>Background:</i></b> Genipin (GP) is a safe method for corneal crosslinking, even very thin corneas. However, there have been no reports on the optimal GP concentration range to use in vivo crosslinking. <b><i>Objectives:</i></b> To investigate safety of crosslinking after 24-h incubation with different concentrations GP. <b><i>Methods:</i></b> Twenty New Zealand white rabbits were divided into phosphate-buffered...
The purpose of the present study was to investigate effect a new crosslinking (CXL) method, induced by enzymes, on porcine corneas. Corneal strip (10x3 mm) pairs obtained from 60 fresh eyes were harvested and divided into four groups, Groups A‑D. Each pair corneal strips incised central part same cornea; one incubated in transglutaminase (Tgase) solution (microbial Tgase 2 produced tissue engineering) other remained untreated as control. CXL A‑D with 2, 1, 0.5 0.25 U/ml solution,...
With the widespread application of immune checkpoint inhibitors, a series adverse events (AEs) related to treatment resulting from alterations in system have emerged that warrant attention. The present study report case patient with reactive cutaneous capillary endothelial proliferations (RCCEPs) on eye lid, following programmed cell death protein 1 inhibitor camrelizumab (SHR‑1210) for stage IIa2 well‑ moderately differentiated squamous carcinoma cervix. Although RCCEPs been revealed be...
Abstract Background Lipid metabolism has essential roles in skin barrier formation and the regulation of inflammation. homeostasis regulates melanogenesis, although underlying mechanism remains largely unknown. Sterol regulatory element binding protein 1 (SREBP-1) is a key transcription factor for cellular lipid metabolism. Loss-of-function variants SREBF1 are responsible autosomal-dominant ichthyosis follicularis, alopecia photophobia syndrome, emphasizing significance keratinization....
A bstract Purpose: The aim of this study is to determine the relationship between retinal abnormalities and brain white matter hyper‐intensities (WMH) in symptomatic patients with cerebral autosomal dominant arteriopathy subcortical infarcts leucoencephalopathy (CADASIL). Methods: Fifteen CADASIL fifteen age‐matched healthy control individuals were enrolled study. Ophthalmological examinations performed on all subjects underwent MRI scanning. Retinal artery graded according...