A5043855304- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Epilepsy research and treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Pineapple and bromelain studies
- Neuropeptides and Animal Physiology
- Garlic and Onion Studies
- Pain Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Metabolism and Genetic Disorders
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- Domain Adaptation and Few-Shot Learning
- Neuroscience and Neural Engineering
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Nicotinic Acetylcholine Receptors Study
- Nerve injury and regeneration
- Genomics and Rare Diseases
Peking University
2016-2025
Tianjin Medical University General Hospital
2025
Sichuan University
2014-2025
Wuhan University
2021-2025
Chinese Institute for Brain Research
2015-2025
Ningxia Medical University
2023-2025
Guangzhou University of Chinese Medicine
2024-2025
Kunming University
2025
Changhai Hospital
2025
Second Military Medical University
2025
The hormone jasmonate (JA), which functions in plant immunity, regulates resistance to pathogen infection and insect attack through triggering genome-wide transcriptional reprogramming plants. We show that the basic helix-loop-helix transcription factor (TF) MYC2 tomato (Solanum lycopersicum) acts downstream of JA receptor orchestrate JA-mediated activation both wounding responses. Using chromatin immunoprecipitation sequencing (ChIP-seq) coupled with RNA (RNA-seq) assays, we identified 655...
MAX2 (for MORE AXILLARY GROWTH2) has been shown to regulate diverse biological processes, including plant architecture, photomorphogenesis, senescence, and karrikin signaling. Although is a smoke-derived abiotic signal, role for in stress response pathways least investigated. Here, we show that the max2 mutant strongly hypersensitive drought compared with wild-type Arabidopsis (Arabidopsis thaliana). Stomatal closure of was less sensitive abscisic acid (ABA) than wild type. Cuticle thickness...
Significance Basal lateral amygdala and ventral CA1 are critical sites during chronic stress-induced depression. Here we demonstrated that AMPARs mediated weakening of pBLA-vCA1 innervation in mice subjected to CUMS. Stimulation via chemogenetics or administration cannabidiol (CBD) could reverse synaptosomal AMPAR decrease alleviate CUMS-induced depressive-like behaviors. These findings highlighted the importance an animal model depression revealed potential for CBD major treatment.
Hyperpolarization-activated cation nonselective 1 (HCN1) plasticity in entorhinal cortical (EC) and hippocampal pyramidal cell dendrites is a salient feature of temporal lobe epilepsy. However, the significance remains undetermined. We demonstrate that adult HCN1 null mice are more susceptible to kainic acid-induced seizures. After termination these with an anticonvulsant, also developed spontaneous behavioral seizures at significantly rapid rate than their wild-type littermates. This...
Abstract To restrict pathogen entry, plants close stomata as an integral part of innate immunity. counteract this defense, Pseudomonas syringae pv tomato produces coronatine (COR), which mimics jasmonic acid (JA), to reopen for bacterial entry. It is believed that abscisic (ABA) plays a central role in regulating bacteria-triggered stomatal closure and reopening requires the JA/COR pathway, but downstream signaling events remain unclear. We studied immunity (Solanum lycopersicum) report here...
Acetylcholine critically influences hippocampal-dependent learning. Cholinergic fibers innervate hippocampal neuron axons, dendrites, and somata. The effects of acetylcholine on axonal information processing, though, remain unknown. By stimulating cholinergic making electrophysiological recordings from dentate gyrus granule cells, we show that synaptically released preferentially lowered the action potential threshold, enhancing intrinsic excitability synaptic potential-spike coupling. These...
Scn2a encodes the voltage-gated sodium channel Na
Abstract The human SLC26 transporter family exhibits various transport characteristics, and member SLC26A9 performs multiple roles, including acting as Cl – /HCO 3 exchangers, channels, Na + transporters. Some mutations of are correlated with abnormalities in respiration digestion systems. As a potential target colocalizing CFTR cystic fibrosis patients, is great value drug development. Here, we present cryo-EM structure the dimer at 2.6 Å resolution. A segment C-terminal end bound to entry...
Abstract In mammals, many organs lack robust regenerative abilities. Lost cells in impaired tissue could potentially be compensated by converting nearby situ through vivo reprogramming. Small molecule-induced cell reprogramming offers a temporally flexible and non-integrative strategy for altering fate, which is, principle, favorable with notoriously poor abilities, such as the brain. Here, we demonstrate that adult mouse brain, small molecules can reprogram astrocytes into neurons. The...
Digital finance has a substantial effect on macroeconomics and plays an important role in corporate investment behaviour. However, few studies examine how digital affects efficiency. We use the data of Chinese A-share listed companies for 2011–2017 provincial index developed by Peking University to document that significantly improves Our findings are supported extensive robustness tests. In addition, we identify two mechanisms which may affect efficiency: reducing financing constraints...
N-type voltage-gated calcium (CaV) channels mediate Ca2+ influx at presynaptic terminals in response to action potentials and play vital roles synaptogenesis, release of neurotransmitters, nociceptive transmission. Here, we elucidate a cryo-electron microscopy (cryo-EM) structure the human CaV2.2 complex apo, ziconotide-bound, two CaV2.2-specific pore blockers-bound states. The second voltage-sensing domain (VSD) is captured resting-state conformation, trapped by phosphatidylinositol...
Abstract The low-voltage activated T-type calcium channels regulate cellular excitability and oscillatory behavior of resting membrane potential which trigger many physiological events have been implicated with diseases. Here, we determine structures the human Ca V 3.3 channel, in absence presence antihypertensive drug mibefradil, antispasmodic otilonium bromide antipsychotic pimozide. contains a long bended S6 helix from domain III, positive charged region protruding into cytosol, is...
Abstract The voltage-gated calcium channel Ca V 1.2 is essential for cardiac and vessel smooth muscle contractility brain function. Accumulating evidence demonstrates that malfunctions of are involved in heart diseases. Pharmacological inhibition therefore therapeutic value. Here, we report cryo-EM structures the absence or presence antirheumatic drug tetrandrine antihypertensive benidipine. Tetrandrine acts as a pore blocker pocket composed S6 II , III IV helices forms extensive hydrophobic...
Skeletal muscles represent a role model in soft robotics featuring agile locomotion and incredible mechanical robustness. However, existing actuators lack an optimal combination of actuation parameters (including modes, work capacity, strength, damage repair) to rival biological tissues. Here, biomimetic structural design strategy via multilevel relaxations (α/β/γ/δ-relaxation) modulation is proposed for robust healable actuator materials with muscle-like diastole contraction abilities by...
Background Ganoderma lucidum (Reishi or Ling Zhi) is one of the most famous Traditional Chinese Medicines and has been widely used in treatment various human diseases Asia countries. It also a fungus with strong wood degradation ability potential bioenergy production. However, genes, pathways mechanisms these functions are still unknown. Methodology/Principal Findings The genome G. was sequenced assembled into 39.9 megabases (Mb) draft genome, which encoded 12,080 protein-coding genes ∼83%...
Lung squamous cell carcinoma (LUSC) is often diagnosed at the advanced stage with poor prognosis. The mechanisms of its pathogenesis and prognosis require urgent elucidation. This study was performed to screen potential biomarkers related occurrence, development LUSC reveal unknown physiological pathological processes. Using bioinformatics analysis, lung microarray datasets from Gene Expression Omnibus (GEO) Cancer Genome Atlas (TCGA) databases were analyzed identify differentially expressed...
Systematic administration of anti-inflammatory cytokine interleukin 4 (IL-4) has been shown to improve recovery after cerebral ischemic stroke. However, whether IL-4 affects neuronal excitability and how improves injury remain largely unknown. Here we report the neuroprotective role endogenous in focal ischemia–reperfusion (I/R) injury. In multi-electrode array (MEA) recordings, reduces spontaneous firings network activities mouse primary cortical neurons. mRNA protein expressions are...