A5026064487- Algal biology and biofuel production
- Diet and metabolism studies
- Gut microbiota and health
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Photosynthetic Processes and Mechanisms
- Marine and coastal ecosystems
- Climate Change and Health Impacts
- COVID-19 and Mental Health
- Health disparities and outcomes
- Aquatic Ecosystems and Phytoplankton Dynamics
- Birth, Development, and Health
- Natural Compounds in Disease Treatment
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- HIV/AIDS Research and Interventions
- Breastfeeding Practices and Influences
- Impact of Technology on Adolescents
- Microbial Metabolic Engineering and Bioproduction
- Regulation of Appetite and Obesity
- Air Quality and Health Impacts
- Antioxidant Activity and Oxidative Stress
- Vitamin D Research Studies
Beijing University of Technology
2019-2025
Jiangnan University
2023-2025
East China University of Science and Technology
2025
Tianjin Agricultural University
2025
Shanghai University
2024
University of Science and Technology Beijing
2024
Peking University
2015-2022
Nanjing Maternity and Child Health Care Hospital
2021-2022
Nanjing Medical University
2021-2022
Shenzhen University
2019-2021
Photosynthetic microalgae are emerging as potential biomass feedstock for sustainable production of biofuels and value-added bioproducts. CO2 biomitigation through these organisms is considered an eco-friendly promising alternative to the existing carbon sequestration methods. Nonetheless, inherent relatively low photosynthetic capacity has hampered practical use this strategy applications. Here, we demonstrate feasibility improving by genetic manipulation Calvin cycle in typical green...
Parkinson's disease (PD) is a chronic neurodegenerative disorder that characterized by motor symptoms as result of loss dopaminergic neurons in the substantia nigra pars compacta (SNc), accompanied neuroinflammation, oxidative stress, formation α-synuclein aggregates. Celastrol, potent anti-inflammatory and anti-oxidative pentacyclic triterpene, has emerged neuroprotective agent. However, mechanisms which celastrol PD remain elusive. Here we show protects against dopamine neuron loss,...
Fucoxanthin has been receiving ever-increasing interest due to its broad health beneficial effects. Currently, seaweeds are the predominant source of natural fucoxanthin. However, disappointingly low fucoxanthin content impeded their use, driving exploration alternative producers. In present study, thirteen diatom strains were evaluated with respect growth and production potential. Cyclotella cryptica (CCMP 333), which grew well for under both photoautotrophic heterotrophic conditions, was...
Background: The frequency of take-out food consumption has increased rapidly among Chinese college students, which contributed to high obesity prevalence. However, the relationships between consumption, body mass index (BMI), and other individual factors influencing eating behavior students are still unclear. This study explored association with gender, BMI, physical activity, preference for high-fat high-sugar (HFHS) food, major category, degree level students. Methods: Cross-sectional data...
Fucoxanthin supplementation to NCD or HFD significantly reduced the bodyweight gain in mice likely through its capability differentially modulate cecal and fecal microbiota based on diet.
The objective of this study was to investigate the effect light on lipid and starch accumulation in oleaginous green algae Chlorella zofingiensis supplemented with glucose. C. zofingiensis, when fed 30 g/L glucose, synthesized lipids up 0.531 g/g dry weight; while presence light, content dropped down 0.352 weight. Lipid yield glucose 0.184 14% higher than that cultured light. light-mediated reduction accompanied by down-regulation fatty acid biosynthetic genes at transcriptional level....
Scope The aim of the present study is to investigate efficacy Nitzschia laevis extract (NLE) in preventing obesity mice fed with a high‐fat diet (HFD), and potential underlying mechanisms focusing on modulation gut microbiota profile. Methods results Physiological, histological, biochemical parameters compositions are compared among four experimental groups respectively following diets for 8 weeks: Normal chow diet, HFD, HFD + low concentration NLE, high NLE. demonstrate that NLE...
The extract of microalga Nitzschia laevis (NLE) is considered a source dietary fucoxanthin, carotenoid possessing variety health benefits. In the present study, bioaccessibility and deacetylation fucoxanthin were studied by simulated in vitro gastrointestinal digestion colonic batch fermentation. gastric phase, higher loss was observed at pH 3 compared to 4 5. Lipases are crucial for into fucoxanthinol. Fucoxanthinol production decreased significantly order: pure (25.3%) > NLE (21.3%)...
Long-term high sugar accelerates skin ageing via glycosylation. In this study, microalgae-derived active compounds were investigated for their potentially beneficial effects on ageing. Two carotenoids, namely astaxanthin (in the form of either monoester or diester) and lutein, separated from green alga Haematococcus pluvialis. These carotenoid fractions significantly attenuated glucose (HG)-induced cell injury oxidative stress. They also inhibited formation Nε-Carboxymethyllysine (CML), a...
As an important part of the urban landscape, lakes not only enhance overall environmental quality a city, but also strengthen residents’ sense well-being and cultural identity. With acceleration urbanization, water ecological health have become increasingly prominent issues. However, there is lack quantitative research on effects lake shape spatial temporal distribution hydrodynamics quality. Using Environmental Fluid Dynamics Code (EFDC) model, this study simulates hydrodynamic...
Fucoxanthin, a kind of exclusively algae-derived carotenoids, could reduce lipid content and regulate gut microbiota composition in obese mice, showing potential preventing hyperlipidemia. This study aimed to illustrate fucoxanthin efficacy modulating metabolism serum liver high-fat-induced hyperlipidemia as well investigate the underlying association with changes. Results showed that significantly reduced body weight gain white fat mice. In serum, total triglycerides (TG), cholesterol (TC)...
Fucoxanthin, a carotenoid exclusively derived from algae, exerts its bioactivities with the modulation of gut microbiota in mice. However, mechanisms through which fucoxanthin regulates and metabolites/metabolism humans remain unclear. In this study, we investigated effects on metabolism non-obese individuals using an vitro simulated digestion-fermentation cascade model. The results showed that about half was not absorbed intestine, thus reaching colon. fecal samples underwent significant...
Introduction The current field of research on the impact COVID-19 mental health was mostly limited to evaluation first round epidemic, few reports focused re-emergence COVID-19. This study aimed investigate literacy and status residents during re-outbreak in China. Methods basic information sheet, survey scale, physical questionnaire-9 (PHQ-9), generalized anxiety disorder-7 (GAD-7), insomnia severity index (ISI), Alzheimer dementia 8 (AD8) were applied evaluate literacy, elderly cognitive...
Objectives To assess if the maternal pre-pregnancy weight status (MPWS) alters association of early infant feeding pattern (at one and third months) with body mass index (BMI) in first two years life. Methods A cohort 2,220 neonates were recruited a community-based study conducted China. Body length measured at birth, age two, BMI calculated accordingly. The z-scores (BMI-Z) computed according to World Health Organization Growth Standard (2006). Feeding patterns classified as exclusive...
Abstract The RII β subunit of cAMP‐dependent protein kinase A (PKA) is expressed in the brain and adipose tissue. ‐knockout mice show leanness increased UCP1 brown authors have previously reported that reexpression hypothalamic GABAergic neurons rescues leanness. However, whether white tissue (WAT) browning contributes to ‐PKA these governs WAT are unknown. Here, this work reports ‐KO exhibit a robust browning. dorsal median (DMH neurons) abrogates Single‐cell sequencing, transcriptome...
The increasing prevalence of obesity has resulted in demands for the development new effective strategies treatment. Withaferin A (WA) shows a great potential prevention by sensitizing leptin signaling hypothalamus. However, mechanism underlying weight- and adiposity-reducing effects WA remains to be elucidated. In this study, we report that treatment induced white adipose tissue (WAT) browning, elevated energy expenditure, decreased respiratory exchange ratio, prevented high-fat...