A5100643202- Computational Drug Discovery Methods
- Natural product bioactivities and synthesis
- Spectroscopy and Chemometric Analyses
- Chromatography in Natural Products
- Synthesis of Organic Compounds
- Phytochemicals and Antioxidant Activities
- Flavonoids in Medical Research
- Stroke Rehabilitation and Recovery
- Traditional Chinese Medicine Analysis
- Lignin and Wood Chemistry
- Health Education and Validation
- Endoplasmic Reticulum Stress and Disease
- Heavy Metals in Plants
- Mathematical Biology Tumor Growth
- Food Quality and Safety Studies
- Imbalanced Data Classification Techniques
- Spinal Fractures and Fixation Techniques
- Berberine and alkaloids research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Natural Antidiabetic Agents Studies
- Bioinformatics and Genomic Networks
- Ginger and Zingiberaceae research
- Sleep and related disorders
- Advanced Chemical Sensor Technologies
- Advanced Graph Neural Networks
Air Force Medical University
2024
Jiangnan University
2022
China Resources (China)
2022
Chinese Academy of Sciences
2022
University of Chinese Academy of Sciences
2022
Peking University
2021
Capital Medical University
2020
Shandong Academy of Chinese Medicine
2010-2019
Shandong University of Traditional Chinese Medicine
2019
Huashan Hospital
2015-2017
Graph classification is a challenging research task in many applications across broad range of domains. Recently, Neural Network (GNN) models have achieved superior performance on various real-world graph datasets. Despite their successes, most current GNN largely suffer from the ubiquitous class imbalance problem, which typically results prediction bias towards majority classes. Although imbalanced learning methods been proposed, they mainly focus regular Euclidean data and cannot well...
Liang Wangab, Dai-Jie Wangc, Wei Guoab, Kai-Bin Suna, Na-Na Huangd & Rong Sunade*a School of Pharmaceutical Sciences, Shandong University Traditional Chinese Medicine , Jinan 250355 China ; b Academy 250014 c Analysis and Test Center, Qilu Technology (Shandong Sciences) d The Second Hospital 250033 e Advanced Medical Science, 250012
Eating difficulties are common among patients affected by stroke. A valid, reliable instrument for assessing eating in people with stroke is needed. The aim of this study was to translate the Minimal Observation Form - version II (MEOF-II) into Chinese and comprehensively evaluate its reliability validity.The scale original MEOF-II form translated using cross-culture translation method, 125 participants were assessed. Data analysed content validity index, Cronbach's alpha, correlations...
SMBA1 (small-molecule Bax agonists 1), a small molecular activator of Bax, is potential anti-tumour agent. In the present study, we investigated biological effects on glioblastoma (GBM) cells. reduced viabilities U87MG, U251 and T98G cells in time- dose-dependent manner. Moreover, treatment with induced cell cycle arrest at G2/M phase transition, accompanied by downregulation Cdc25c cyclin B1 upregulation p21. also apoptosis GBM Mechanistically, via intrinsic pathway. Silencing or ectopic...
A simple, rapid and highly sensitive liquid chromatographic–tandem mass spectrometry (LC–MS-MS) method has been developed validated for the quantification of amoxicillin in broth—a bacterial culture medium. After appropriate dilution with ultrapure water, broth samples containing an internal standard (IS) were extracted by acetonitrile dichloromethane. The extract was injected into system. analyte IS separated a prepacked Atlantis C18 column using acetonitrile–0.1% formic acid as mobile...
Dual-target therapeutic strategies have become a compelling approach and attracted significant attention due to various benefits, such as their potential in overcoming drug resistance cancer therapy. Considering the tremendous success that deep generative models achieved structure-based design recent years, we formulate dual-target task curate novel dataset of target pairs based on synergistic combinations. We propose drugs with diffusion are trained single-target protein-ligand complex...
Glioma is the most common malignant brain tumor. Previous studies have reported that calnexin (CANX) significantly up-regulated in a variety of tumors, including glioma, but its biological function and mechanism glioma still unclear. In this study, differentially expressed proteins 3 primary glioblastoma multiforme (GBM) tissues paracancer were identified by liquid chromatography-tandem mass spectrometry-based proteomic bioinformatic analysis. The molecular CANX studied cell lines (T98G...
In this paper, a model for evaluating the quality of Baikal skullcap root based on chromatographic fingerprint and pharmacological effect correlation mode was established by using multivariate polynomial fitting technique. This result is new accuracy tested comparing modeled results with experimental data. addition, related piece software developed. paper also provides us modelling method evaluation traditional Chinese herbal medicine.
The leaves of Morus alba (LMA) are crucial traditional Chinese medicine (TCM) clearing heat. In ancient materia medica and the current Pharmacopoeia People’s Republic China, LMA recorded to be harvested after frost for medicinal purpose. However, reason mechanism this usage have been still unknown so far. work, it was confirmed firstly that antipyretic effect better than before significantly on feverish rats. Subsequently, chemical profiles were characterized by fingerprint, respectively....
Objective To explore the effects of ingestion training based on food form modification improving swallowing function among disorder patients after stroke. Methods From January 2018 and June 2019, this study selected 80 stroke Department Rehabilitation at Xuanwu Hospital Capital Medical University as subjects by convenience sampling.All were divided into control group observation with random number table, 40 cases in each group.Control carried out routine training. On basis that,...
In this paper, with the aid of a quality evaluation model, we study sensitivity analysis system for Baikal skullcap root and compute related indices, hence determine response pharmacological effect under model by varying chromatographic fingerprint data. This result is new provides us feasible method Traditional Chinese Herbal Medicine.