A5101745232- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Privacy-Preserving Technologies in Data
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Cryptography and Data Security
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Identification and Quantification in Food
- Genomics and Phylogenetic Studies
- Fish Biology and Ecology Studies
- Circular RNAs in diseases
- Kruppel-like factors research
- Cell Image Analysis Techniques
- Enhanced Recovery After Surgery
- Spider Taxonomy and Behavior Studies
- Ginger and Zingiberaceae research
- Pharmacological Effects of Medicinal Plants
- Blockchain Technology Applications and Security
- Autophagy in Disease and Therapy
- bioluminescence and chemiluminescence research
- Digital Media and Visual Art
- Atherosclerosis and Cardiovascular Diseases
- Yersinia bacterium, plague, ectoparasites research
Zhejiang University
2021-2024
Huzhou Central Hospital
2018-2024
Huzhou University
2023-2024
Zhejiang Normal University
2017-2024
Hong Kong Polytechnic University
2022
Northwestern Polytechnical University
2022
Dalian Medical University
2021
Second Affiliated Hospital of Chongqing Medical University
2021
Chongqing Medical University
2021
First Affiliated Hospital of Xi'an Jiaotong University
2016
TUBA1C, a microtubule component, contributes to the development of several cancers. Our purpose was study expression its potential prognostic value, and effects on infiltration immune cells low-grade glioma (LGG). Through applying multiple bioinformatics analyses, we extracted analyzed datasets from TCGA, TIMER, GTEx, GEPIA, HPA investigate oncogenic mechanisms including correlation between TUBA1C prognosis, immune-checkpoints, tumor microenvironment (TME), in LGG. GO functional annotations...
N-myristoyltransferase-1 (NMT1) catalyzes protein posttranslational myristoylation and functions as an oncogene in various cancers, although its roles bladder cancer remain elusive. Here, we demonstrated that NMT1 was obviously upregulated correlated with overall survival poor prognosis. Elevation of promotes progression inhibits autophagy vitro vivo. Furthermore, confirm LAMTOR1 myristoylated by at Gly 2, resulting increased stability lysosomal localization. Importantly, B13, inhibitor...
MS4A6A has been recognized as being associated with aging and the onset of neurodegenerative disease. However, mechanisms in glioma biology prognosis are ill-defined. Here, we show that is upregulated tissues, resulting unfavorable clinical outcomes poor responses to adjuvant chemotherapy. Multivariate Cox regression analysis suggested expression can act a strong independent predictor for (CGGA1: HR: 1.765, p < 0.001; CGGA2: 2.626, TCGA: 1.415, Rembrandt: 1.809, Gravendeel: 1.613,...
Stroke is the fifth leading cause of death worldwide, and functional status gut plays a key role in patients' prognosis. Recent publications have explored association with stroke, but few articles been published that specifically address comprehensive bibliometric analysis microbiota its stroke. To this gap, we used methods to examine landscape research concerning stroke over approximately two decades, utilizing Web Science Core Collection (WoSCC). On November 1, 2022, search was conducted...
Microdata, such as customer transactional data, play an important role in data mining area. To protect privacy of individuals, microdata should be anonymized or desensitized before publishing it. Anatomy is a popular technique to anonymize microdata. However, the cannot resist linking attacks for reason that it does not distort quasi-identifier attributes. overcome disadvantage anatomy, we propose method combining anatomy with permutation The proposed anonymizes two major steps: (1)...
Hierarchical Federated Learning (HFL) improves the scalability and communication efficiency of system achieves load balancing at each level. Incentive mechanisms enhance participant motivation optimize resource allocation for HFL. However, existing mainly focus on maximizing individual utility from quantity client data while neglecting to social learning quality perspective. Meanwhile, strategic behavior heterogeneous devices can significantly degrade performance incentive mechanisms. To...
MicroRNA-562 (miR-562) has been found to possess anti-cancer function in certain tumors. However, the of miR-562 glioblastoma (GBM) is still not fully understood.The aim at present study analyze and its possible target GBM cells.In study, a total 80 samples 16 adjacent noncancerous tissues were used examine expression c-MET. In order gain deep insight into molecular network c-MET GBM, mimic inhibitor transfected two cell lines (U251 U87), respectively. Meanwhile, lentiviral vector was...
Increasing evidence has indicated that abnormal epigenetic factors such as RNA m6A modification, histone DNA methylation, binding proteins and transcription are correlated with hepatocarcinogenesis. However, it is unknown how modification-associated genes contribute to the occurrence clinical outcome of hepatocellular carcinoma (HCC). Thus, we constructed models may enhance diagnosis prognosis HCC.In this study, focused on value for HCC. Our gene expression data were collected from TCGA HCC...
SMBA1 (small-molecule Bax agonists 1), a small molecular activator of Bax, is potential anti-tumour agent. In the present study, we investigated biological effects on glioblastoma (GBM) cells. reduced viabilities U87MG, U251 and T98G cells in time- dose-dependent manner. Moreover, treatment with induced cell cycle arrest at G2/M phase transition, accompanied by downregulation Cdc25c cyclin B1 upregulation p21. also apoptosis GBM Mechanistically, via intrinsic pathway. Silencing or ectopic...
Fraxetin (FXT) exerts anticancer function in multiple cancers, but its on glioma was ill-defined. This article expounded the mechanism by which FXT an effect glioma. The of gradient concentration viability cell lines determined counting kit 8. Effects proliferation, apoptosis, and cycle were colony formation assay, flow cytometry, Hoechst 33342 staining. Expressions apoptosis-related gene, cycle-related glioma-related miRNAs after (25 50 μmol/L) treatment quantitative reverse transcription...
Abstract Gliomas account for about 80% of malignant brain tumors. The incidence a new tumor is 6.4 per 100,000 persons year with an overall 5‐year survival rate 33.4%. Regardless the great advances that have been made in recent years, causes and pathogenesis glioma remain unclear. Here we study how phosphoglycerate mutase 4 (PGAM4) contributes to glioma. Using variety methods examine cell viability, proliferation, apoptosis, glycolysis, as well ChIP coanalysis modified histone H3, showed...
Glioma is the common, most aggressive and poorest prognostic tumor type in brain. More more biomarkers associated with glioma treatment, prognosis, immunity are being discovered. Here, we aimed to explore underlying biological functions predictive value of Apolipoprotein L4 (APOL4) glioma. We downloaded expression data APOL4 clinical information from several databases used R software for preprocessing. The significance a outcome was explored by Cox regression analysis Kaplan–Meier survival...
Generative adversarial networks (GANs) have been widely used for creating diverse data such as images, audio, and videos. However, the training of GANs often contain sensitive information, they are vulnerable to privacy attacks on dataset, membership inference (MIAs). To improve resistance MIA while ensuring their performance, we design a novel GAN framework PGAN-KD (member Privacy protection based Knowledge Distillation). prevents discriminator from leaking information by introducing...