A5100711483- Animal Vocal Communication and Behavior
- Marine animal studies overview
- Animal Behavior and Reproduction
- Avian ecology and behavior
- Developmental Biology and Gene Regulation
- Glycosylation and Glycoproteins Research
- Metabolism, Diabetes, and Cancer
- Advanced Nanomaterials in Catalysis
- Inflammatory mediators and NSAID effects
- Neurogenesis and neuroplasticity mechanisms
- Antioxidant Activity and Oxidative Stress
- Gout, Hyperuricemia, Uric Acid
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Plant biochemistry and biosynthesis
- Metabolism and Genetic Disorders
- Hippo pathway signaling and YAP/TAZ
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Nicotinic Acetylcholine Receptors Study
- Vagus Nerve Stimulation Research
- Inflammasome and immune disorders
- Breast Lesions and Carcinomas
- Paleontology and Evolutionary Biology
Beijing University of Chinese Medicine
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Wangjing Hospital of China Academy of Chinese Medical Sciences
2024
Hainan Normal University
2004-2023
Xiangshan County First People's Hospital
2023
University of South China
2023
Hainan Agricultural School
2023
Chongqing Medical and Pharmaceutical College
2021-2022
Chongqing Medical University
2021-2022
China Medical University
2019-2022
Metformin has been reported to function as the anti-tumor inhibiting growth of different types cancers, including bladder cancer. But there are few reports on roles Yap1, key molecule Hippo pathway, in metformin induced inhibition cancer (BLCA). We wondering if inhibitory effect is fulfilled via Yap1 and exploring related mechanism. MTS colony formation assays were used explore cellular viabilities proliferation BLCA cells challenged by at concentrations, vitro. Flow Cytometry (FCM) was...
Multidrug-resistant (MDR) pathogenic bacterial infections have become a major danger to public health. Synergetic therapy through multiple approaches is more powerful than the respective one alone, but has been rarely achieved in defeating MDR so far. Herein, indocyanine green-functionalized Mn3 O4 nanosheets are engineered as an efficient and safe antibacterial agent with photothermal, photodynamic, oxidase-like activities, which display ability treating infections. Therein, photothermal...
Cervical cancer, among the deadliest cancers affecting women globally, primarily arises from persistent infection with high-risk human papillomavirus (HPV). To effectively combat and prevent progression of precancerous lesions into malignancy, a therapeutic HPV vaccine is under development. This study utilized an immunoinformatics approach to predict epitopes cytotoxic T lymphocytes (CTLs) helper (HTLs) using E6 E7 oncoproteins HPV16 strain as target antigens. Subsequently, through...
Peroxisome proliferator-activated receptor γ (PPARγ) is a key regulator of glucose homeostasis and lipid metabolism, an important target for the development modern anti-diabetic drugs. However, current PPARγ-targeting drugs such as classical thiazolidinediones (TZDs) are associated with undesirable side effects. To address this concern, we here describe structure-based design, synthesis, identification detailed in vitro vivo characterization novel, decanoic acid (DA)-based selective PPARγ...
The discordance of estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), and Ki-67 cell nuclear proliferation antigen status in patients with locally advanced breast cancer pre- post-neoadjuvant chemotherapy (NAC) is quite common. This study aimed to assess the frequency changes after NAC invasive ductal prognostic impact such changes.The comprised 670 who were diagnosed carcinoma treated both surgery from 2012-2017. Hormone (HR; including ER PR), HER2, was...
Abstract The neuropeptide immunohistochemistry and neural connectivity of areas surrounding the thalamic auditory nucleus (the ovoidalis [Ov]), as well to which it is connected, were investigated in a songbird, Bengalese finch. results showed that met‐enkephalin was present Ov shell most connected it, but not core. Anterograde retrograde tracing studies more widely than mainly to: 1) flanking primary telencephalic field (i.e., fields L2b, L1, L3) robust archistriatum (RA); 2) several...
Song control nuclei have distinct sexual differences and thus are an ideal model to address how brain areas sexually differentiated. Through a combination of histological analysis electrical lesions, we first identified the ventricle site for HVC progenitor cells. We then found that there were significant sex in cellular proliferation activity ventricular zone HVC, number migrating cells along radial (positive immunoreactions vimentin) differentiation towards neurons. co-culturing male...
Virus-mediated expression of defined transcription factor (TF) genes can effectively induce cellular reprogramming. However, sustained the TFs often hinders pluripotent stem cell (PSC) differentiation into specific types, as each TF exerts its effect on PSCs for a period time during differentiation. Here, we applied bacterial type III secretion system (T3SS)-based protein delivery tool to directly translocate in form human PSCs. This transient technique showed high efficiency hPSCs, and it...
Abstract Early comparative embryogenesis can reflect the organization and evolutionary origins of brain areas. Neurogenesis in auditory areas sauropsids displays a clear core‐to‐shell distinction, but it remains unclear mammals. To address this issue, [ 3 H]‐thymidine was injected into pregnant mice on consecutive embryonic (E) days (E10–E19) to date neuronal birthdays. Immunohistochemistry for substance P, calbindin, parvalbumin conducted distinguish core shell regions. The results showed...
There is a clear core-versus-shell distinction in cytoarchitecture, electrophysiological properties and neural connections the mesencephalic diencephalic auditory nuclei of amniotes. Determining whether embryogenesis shows similar organization helpful for further understanding constituent evolution nuclei. Therefore present study, we injected [<sup>3</sup>H]-thymidine into turtle embryos <i>(Pelodiscus sinensis)</i> at various stages development. Upon hatching,...
Abstract To characterize the neurogenic development of visual areas turtle ( Pelodiscus sinensis ) during embryogenesis, a single dose [ 3 H]‐thymidine (10 µCi) was injected into egg yolks from stages S11~12 to S21. At hatching, localization incorporation examined, and led three main observations. (1) Neurogenesis occurred in stratum griseum centrale tectum opticum S16 with peak at S12. No obvious gradients neurogenesis were observed. (2) nucleus rotundus (Rot) dorsal lateral geniculate...