A5063530769- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- CAR-T cell therapy research
- Enzyme Catalysis and Immobilization
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- Plant Stress Responses and Tolerance
- Plant responses to water stress
- TGF-β signaling in diseases
- Plant Water Relations and Carbon Dynamics
- Microbial Metabolic Engineering and Bioproduction
- Plant Gene Expression Analysis
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Antibiotics Pharmacokinetics and Efficacy
- RNA Interference and Gene Delivery
- Photosynthetic Processes and Mechanisms
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Anorectal Disease Treatments and Outcomes
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Cyclopropane Reaction Mechanisms
Central South University
2021-2025
National Sun Yat-sen University
2025
Kaifeng University
2025
Tianjin Medical University Cancer Institute and Hospital
2020-2024
Wuhan University
2023
Zhongnan Hospital of Wuhan University
2023
Sichuan Academy of Forestry
2023
Sichuan Agricultural University
2022-2023
Yangtze University
2019-2022
Shandong Agricultural University
2022
Lymph node metastasis (LNM) is the prominent route of gastric cancer dissemination, and usually leads to tumor progression a dismal prognosis cancer. Although exosomal lncRNAs have been reported be involved in development, whether secreted can encode peptides recipient cells remains unknown. Here, we identified an lncRNA (lncAKR1C2) that was clinically correlated with lymph VEGFC-independent manner. Exo-lncAKR1C2 from demonstrated enhance tube formation migration lymphatic endothelial cells,...
Abstract MicroRNAs (miRNAs) are involved in the progression of many cancers through largely unelucidated mechanisms. The results our present study identified a gene cluster, miR‐221/222, that is constitutively upregulated serum exosome samples patients with colorectal carcinoma (CRC) liver metastasis (LM); this upregulation predicts poor overall survival rate. Using an vitro cell coculture model, we demonstrated CRC exosomes harboring miR‐221/222 activate hepatocyte growth factor (HGF) by...
Abstract Mesenchymal stem cells (MSCs) are a promising cellular vehicle for transferring anti-cancer factors to malignant tumors. Currently, variety of agents, including the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), have been loaded into MSCs derived from range sources through different engineering methods. These engineered exhibit enormous therapeutic potential various cancers. To avoid intrinsic defects tissues and risk viral vectors, TRAIL was...
Tipburn is a physiological disease in Chinese cabbage. In recent years, this has become increasingly serious, affecting the quality and economic benefits of However, little known about molecular mechanism by which calcium deficiency induces tipburn. Therefore, we performed transcriptome analysis on Y578-2 (tipburn-resistant accession) Y920-2 (tipburn-susceptible to identify genes involved tipburn defense study, phenotypic observation showed that began display symptoms 10th day treatment....
Abstract Previous studies examining the influence of career plateau on job performance have primarily adopted a social exchange or conservation‐of‐resources perspective, but support for these perspectives has been inconsistent. Our research takes novel theoretical approach by investigating how and when affects through social‐cognitive lens. Specifically, we propose self‐efficacy as mechanism which hierarchical content affect performance, that relationships will be moderated stage. Path...
Natural killer (NK) cell-derived exosomes (NK-Exos) are emerging as a promising avenue in cancer immunotherapy due to their inherent tumor-targeting properties and capacity deliver therapeutic agents directly malignant cells. This research delves into the boosted anti-tumor potency of NK-Exos that has been genetically enhanced overexpress NKG2D, vital activating receptor, along with interleukin-24 (IL24), cytokine renowned for its selective suppressive impact on tumor NKG2D facilitates...
Chinese cabbage (Brassica rapa L. ssp. pekinensis), an important traditional vegetable indigenous to China, is a typical cross-pollinated Brassica crop exhibiting pronounced heterosis. However, its small flower organs make artificial pollination for hybrid seed production highly challenging. The use of male-sterile lines has emerged as crucial approach in production. Therefore, understanding the genetic and molecular mechanisms underlying male sterility holds profound theoretical economic...
Mesenchymal stem cells (MSCs) hold potential in cancer therapy; however, insufficient tumor homing ability and heterogeneity limit their therapeutic benefits. Obviously, the homogeneous induced pluripotent cell (iPSC)-derived mesenchymal (iMSCs) with enhanced of targeting could be solution. In this study, a CAR containing NKG2D extracellular domain was targeted at B2M locus iPSCs to generate NKG2D-CAR-iPSCs, which were subsequently differentiated into NKG2D-CAR-iMSCs. vitro, NKG2D-CAR...
Abstract Gastric cancer (GC) is among the most lethal human malignancies, yet it remains hampered by challenges in fronter of molecular‐guided targeted therapy to direct clinical treatment strategies. The protein tyrosine phosphatase Src homology 2 domain‐containing (SHP2) involved malignant progression GC. However, detailed mechanisms posttranslational modifications SHP2 remain poorly understood. Herein, we demonstrated that an allosteric inhibitor, SHP099, was able block tumor...
Abstract Toward improving the selective adsorption performance of molecularly imprinted polymers in strong polar solvents, this work, a new ionic liquid functional monomer, 1‐butyl‐3‐vinylimidazolium bromide, was used to synthesize sulfamethoxazole polymer methanol. The resulting characterized by Fourier transform infrared spectra and scanning electron microscopy, rebinding mechanism for sulfonamides studied. A static equilibrium experiment revealed that as‐obtained had higher molecular...
Abstract A novel green hydrophilic levofloxacin imprinted polymer was presented via one‐step polymerization in water using ionic liquid 1,6‐hexa‐3,3′‐bis‐1‐vinylimidazolium bromine with multiple groups and 2‐hydroxyethyl methacrylate as a co‐functional monomer. Adsorption experiment revealed that the significantly improved compatible of polymer, excellent recognition molecularly for corresponds to synergetic effect H‐bonding electrostatic π–π interactions between Furthermore, adsorption...
Esterases, lipases, and serine proteases have been applied as versatile biocatalysts for preparing a variety of chiral compounds in industry via the kinetic resolution their racemates. In order to meet this requirement, three approaches enzyme engineering, medium substrate engineering are exploited improve activity enantioselectivity. With hydrolysis (R,S)-mandelates biphasic media consisting isooctane pH 6 buffer at 55 degrees C model system, strategy combined covalent immobilization leads...
Abstract Azolides, that is, N ‐acylazoles, as versatile acylation reagents are well characterized in the literature, which azole structure can not only act a better leaving group but also make carbonyl carbon more electrophilic and susceptible to nucleophilic attack. It is therefore desirable combine this unique property lipase resolution ability development of new process for preparing optically pure carboxylic acids. With Candida antarctica B (CALB) ‐ catalyzed hydrolysis ( R,S )‐...
5-fluorouracil (5-FU)-based chemotherapy is the first line treatment for advanced gastric cancer. However, effectiveness of 5-FU limited by drug resistance. The N-myc downstream-regulated gene, family member 3 (NDRG3) a NDRG and has been implicated in numerous types role NDRG3 cancer remains unclear. In present study, mRNA expression adjacent normal tissues was analyzed using Gene Expression Profiling Interactive Analysis web tool. silenced short hairpin RNAs to examine effect on growth...
Duchenne muscular dystrophy (DMD) is the most common fatal muscle disease, with an estimated incidence of 1/3500–1/5000 male births, and it associated mutations in X-linked DMD gene encoding dystrophin, largest known human gene. There currently no cure for DMD. The large size hampers exogenous addition delivery. genetic correction patient-derived induced pluripotent stem cells (DMD-iPSCs) differentiation into suitable transplantation a promising autologous therapeutic strategy In this study,...
Hemophilia B (HB) is an X-linked recessive disease caused by F9 gene mutation and functional coagulation factor IX (FIX) deficiency. Patients suffer from chronic arthritis death threats owing to excessive bleeding. Compared with traditional treatments, therapy for HB has obvious advantages, especially when the hyperactive FIX mutant (FIX-Padua) used. However, mechanism which FIX-Padua works remains ambiguous due a lack of research models. Here, in situ introduction F9-Padua was performed...
Hemophilia A (HA) is a common X-linked recessive hereditary bleeding disorder. Coagulation factor VIII (FVIII) insufficient in patients with HA due to the mutations F8 gene. The restoration of plasma levels FVIII via both recombinant B-domain-deleted (BDD-FVIII) and (BDDF8) transgenes was proven be helpful. FVIII-Padua 23.4 kb tandem repeat mutation associated high gene expression thrombogenesis. Here we screened core enhancer element for improving expression. In detail, identified 400 bp...