A5090238081- Antimicrobial Peptides and Activities
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Antimicrobial Resistance in Staphylococcus
- MicroRNA in disease regulation
- Microplastics and Plastic Pollution
- Galectins and Cancer Biology
- PARP inhibition in cancer therapy
- Acne and Rosacea Treatments and Effects
- Ubiquitin and proteasome pathways
- Parasites and Host Interactions
- Cancer, Hypoxia, and Metabolism
- Additive Manufacturing Materials and Processes
- Anomaly Detection Techniques and Applications
- Extracellular vesicles in disease
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Welding Techniques and Residual Stresses
- Parasitic infections in humans and animals
- Retinoids in leukemia and cellular processes
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Aquaculture disease management and microbiota
- Histone Deacetylase Inhibitors Research
- Linguistic research and analysis
Tianjin Medical University Cancer Institute and Hospital
2023-2025
Huazhong University of Science and Technology
2024-2025
Tongji Hospital
2024-2025
Nankai University
2025
Sichuan University
2008-2024
Brown University
2018-2023
Rhode Island Hospital
2018-2023
Shougang (China)
2013-2021
Capital Medical University
2020
Peking University
2014-2015
Significance There is a critical lack of therapeutic agents to treat infections caused by nongrowing persister forms methicillin-resistant Staphylococcus aureus (MRSA). Although membrane-disrupting can kill cells, their potential has been mostly overlooked because low selectivity for bacterial versus mammalian membranes. We report that the clinically approved anthelmintic drug bithionol kills MRSA persisters disrupting membrane lipid bilayers at concentrations exhibit levels toxicity cells....
Homologous recombination deficiency (HRD) is prevalent in cancer, sensitizing tumor cells to poly (ADP-ribose) polymerase (PARP) inhibition. However, the impact of HRD and related therapies on microenvironment (TME) remains elusive. Our study generates single-cell gene expression T cell receptor profiles, along with validatory multimodal datasets from >100 high-grade serous ovarian cancer (HGSOC) samples, primarily a phase II clinical trial (NCT04507841). Neoadjuvant monotherapy PARP...
Lymph node metastasis (LNM) is the prominent route of gastric cancer dissemination, and usually leads to tumor progression a dismal prognosis cancer. Although exosomal lncRNAs have been reported be involved in development, whether secreted can encode peptides recipient cells remains unknown. Here, we identified an lncRNA (lncAKR1C2) that was clinically correlated with lymph VEGFC-independent manner. Exo-lncAKR1C2 from demonstrated enhance tube formation migration lymphatic endothelial cells,...
In addition to their established action of synthetic lethality in tumor cells, poly(ADP-ribose) polymerase inhibitors (PARPis) also orchestrate immune microenvironment (TIME) that contributes suppressing growth. However, it remains not fully understood whether and how PARPis trigger tumor-targeting responses.
Cytokines are soluble proteins that exert their functions by binding specific receptors. Many cytokines play essential roles in carcinogenesis and have been developed for the treatment of cancer. In this study, we identified a novel potential cytokine using immunogenomics designated colon-derived SUSD2 factor (CSBF), also known as chromosome 10 open reading frame 99 (C10orf99). CSBF/C10orf99 is classical secreted protein with predicted molecular mass 6.5 kDa functional ligand Sushi Domain...
Resistance or tolerance to traditional antibiotics is a challenging issue in antimicrobial chemotherapy. Moreover, bactericidal kill only actively growing bacterial cells, whereas nongrowing metabolically inactive cells are tolerant and therefore "persist" the presence of legacy antibiotics. Here, we report that diarylurea derivative PQ401, previously characterized as an inhibitor insulin-like growth factor I receptor, kills both antibiotic-resistant antibiotic-tolerant methicillin-resistant...
Purpose: Zinc oxide nanoparticles (ZnO-NPs) have exerted antimicrobial properties. However, there is insufficient evaluation regarding the in vivo antifungal activity of ZnO-NPs. This study aimed to investigate efficacy and mechanism ZnO-NPs controlling Candida albicans invertebrate Galleria mellonella. Methods:Galleria mellonella larvae were injected with different doses determine their toxicity. Non-toxic chosen for prophylactic injection G. followed by C. infection. Then direct vitro...
Ovarian cancer (OC) is prone to peritoneum or omentum dissemination, thus giving rise the formidable challenge of unresectable surgery and a dismal survival rate. Although niraparib holds pivotal role in maintenance treatment OC, its effect on suppressing metastases during primary intervention remains enigmatic. Recently, we initiated prospective clinical study (NCT04507841) order evaluate therapeutic efficacy neoadjuvant monotherapy for advanced OC with homologous recombination deficiency....
Conventional antibiotics are not effective in treating infections caused by drug-resistant or persistent nongrowing bacteria, creating a dire need for the development of new antibiotics. We report that small molecule nTZDpa, previously characterized as nonthiazolidinedione peroxisome proliferator-activated receptor gamma partial agonist, kills both growing and Staphylococcus aureus cells lipid bilayer disruption. S. exhibited no detectable resistance to compound acted synergistically with...
Abstract Gastric cancer (GC) is among the most lethal human malignancies, yet it remains hampered by challenges in fronter of molecular‐guided targeted therapy to direct clinical treatment strategies. The protein tyrosine phosphatase Src homology 2 domain‐containing (SHP2) involved malignant progression GC. However, detailed mechanisms posttranslational modifications SHP2 remain poorly understood. Herein, we demonstrated that an allosteric inhibitor, SHP099, was able block tumor...
Abstract Background New therapeutics are urgently needed for infectious diseases, especially the fungal infection like Fonsecaea monophora . Photodynamic therapy has been showing antimicrobial activity on some pathogens. The combination of medicines and photodynamic (PDT) might be a practical approach. However, whether treatment PDT could do benefits to host immunity remains poorly documented. Results In this study, Galleria mellonella larvae were employed as model organism evaluate PDT,...
Industrial Control Systems (ICSs) have faced a significant increase in malware threats since their integration with the Internet. However, existing machine learning-based identification methods are not specifically optimized for ICS environments, resulting suboptimal performance. In this work, we propose an innovative method explicitly tailored ICSs to enhance performance of classifiers within these systems. Our integrates opcode2vec based on preprocessed features conditional variational...
Cytokines mediate the interaction of immune cells. Discovery novel potential cytokines is great value for both basic research and clinical application. In this study, we identified a immune-related molecule, transmembrane protein 98 (TMEM98), through high-throughput screening platform at genome-wide level using strategy immunogenomics. So far, there no characteristic functional report about it. demonstrate that TMEM98 exists as type II in ectopically endogenously expressed systems....
Cutibacterium acnes is capable of inducing inflammation in acne and can lead to a chronic prostatic infection. The diverse pathogenicity among different strains C. has been presented, but simple appropriate animal models for the evaluation this bacterium are lacking. In study, nematode Caenorhabditis elegans was used as an invertebrate infection model. We revealed that type strain ATCC 6919 caused lethal infections solid liquid culture media (p < .0001). Compared with 6919,...
Acne vulgaris is a complex skin disease involving infection by Cutibacterium acnes, inflammation, and hyperkeratinization. We evaluated the activity of retinoid 6-[3-(adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) 16 other analogs as potential anti-C. acnes compounds found that CD437 displayed highest antimicrobial with an MIC against C. (ATCC 6919 HM-513) 1 μg/mL. demonstrated MBC 2 μg/mL compared to up 64 for adapalene tetracycline, which are commonly used clinically...
Abstract Tumor proliferation, metabolism, metastasis, and chemoresistance are intimately related to the tumor microenvironment (TME). The metabolic reprogramming of cells is a hallmark their adaptation hypoxic nutrient-deficient TMEs. Exosomes, type extracellular vesicle, have been found regulate crosstalk between TME, affecting reprogramming. In this review, we introduce characteristics cells; describe TME in terms glucose lipid amino acid metabolism through exosomes; provide an overview...
MiR-130a is a recently identified critical player in vascular smooth muscle cell (VSMC) proliferation, which participates intracranial aneurysm (IA). However, the involvement of miR-130a IA and its upstream regulator are unknown. Our preliminary sequencing analysis revealed close correlation between lncRNA SAMMSON across samples. Therefore, we further studied crosstalk IA.SAMMSON expression were measured using RT-qPCR. subcellular location was analyzed with nuclear fractionation assay. Their...
A variety of effector proteins contribute to host defense in Caenorhabditis elegans. However, beyond lytic enzymes and antimicrobial peptides proteins, little is known about the exact function these infection-related effectors. This study set out identify pathogen-dependent cytokine-like molecules, focusing on C-type lectin domain-containing (CLECs). In total, 38 CLECs that are differentially regulated response bacterial infections have been previously identified by microarray transcriptome...
Herein, attempts were made to develop W/steel joints via selective laser melting (SLM) for the first time. The influence of processing parameters on joint strength was investigated. To further improve mechanical properties, we performed post-heat treatment as-fabricated specimens. results showed that large amounts solid solution and dispersed micro-/nanoparticles appear in interface fabricated by direct SLM because uniqueness non-equilibrium solidification, which is favourable bonding...
Our aim was to verify the alleviation effect of sphingosine-1-phosphate (S1P) in a miniature pig model.Thirty male pigs were randomly separated into 10 groups our experiment. We administered S1P through parotid duct retrograde fashion 2 hr before irradiation (IR). The salivary flow rate and blood tested 20 weeks after IR. apoptotic level checked at 12, 24 7 days post-IR.Twenty IR, IR-side gland IR + group can be maintained about 40% non-IR side, while only 20% group. microvascular density...
<title>Abstract</title> Gastric cancer (GC), particularly prevalent in China, is associated with high rates of morbidity and mortality. This study focuses on the role mechanistic pathways a novel 127-amino acid peptide, circR-127aa, encoded by hsa_circ_0075402 (circRACK1) GC cells, exploring its implications development. Circular RNAs (circRNAs), which vary expression across different cancers, contribute to tumorigenesis via mechanisms such as miRNA sponging, protein binding, influencing...