A5014658563- Microbial Natural Products and Biosynthesis
- Phytochemical compounds biological activities
- Enzyme Production and Characterization
- Genomics and Phylogenetic Studies
- Antimicrobial Resistance in Staphylococcus
- Marine Sponges and Natural Products
- Plant biochemistry and biosynthesis
- Legionella and Acanthamoeba research
- Carbohydrate Chemistry and Synthesis
- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Bacterial biofilms and quorum sensing
- Microbial Metabolism and Applications
- Synthetic Organic Chemistry Methods
- Plant tissue culture and regeneration
- Studies on Chitinases and Chitosanases
- Oral microbiology and periodontitis research
Emory University
2019
University of Ottawa
2013-2015
Institute of Catalysis and Petrochemistry
2015
Centre for Catalysis Research and Innovation
2015
Ontario Genomics
2013
Significance There is a critical lack of therapeutic agents to treat infections caused by nongrowing persister forms methicillin-resistant Staphylococcus aureus (MRSA). Although membrane-disrupting can kill cells, their potential has been mostly overlooked because low selectivity for bacterial versus mammalian membranes. We report that the clinically approved anthelmintic drug bithionol kills MRSA persisters disrupting membrane lipid bilayers at concentrations exhibit levels toxicity cells....
Abstract Bacterial polyketides are a rich source of chemical diversity and pharmaceutical agents. Understanding the biochemical basis for their biosynthesis evolutionary driving force leading to this is essential take advantage enzymes as biocatalysts access new drug discovery. Biochemical characterization thioesterase (TE) responsible 6‐deoxyerythronolide macrocyclization shows that small, evolutionarily accessible change substrate can increase products, including macrodiolide formation. We...
Transannular 2,6-disubstituted pyrans, like the one found in cytotoxic marine natural product neopeltolide, are a key functional group many polyketides. While oxa-conjugate additions have been shown to provide direct and rapid access tetrahydropyrans acyclic neopeltolide intermediates, transannular strategy for construction of this ring system macrocyclic core has not investigated. In study, we demonstrate that addition is viable approach bicyclic neopeltolide. We show occurs readily with an...
Biofilm-associated infections are linked to chronic and recurring illnesses. These often not susceptible current antibiotic treatments because of the protective exocellular matrix subpopulations dormant or "persister" cells. Targeting bacterial circuitry involved in biofilm formation, including two-component systems, quorum sensing, polysaccharide structural integrity, cyclic nucleotide signaling pathways, has potential expand existing arsenal therapeutics, thus catalyzing a second golden...