A5103909077- Animal Virus Infections Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Reconstructive Surgery and Microvascular Techniques
- Viral Infections and Immunology Research
- Vestibular and auditory disorders
- SARS-CoV-2 and COVID-19 Research
- Marine animal studies overview
- Animal Vocal Communication and Behavior
- Hearing Loss and Rehabilitation
- Reconstructive Facial Surgery Techniques
- Animal Behavior and Reproduction
- Facial Rejuvenation and Surgery Techniques
- Ear Surgery and Otitis Media
- Tracheal and airway disorders
- Pregnancy and preeclampsia studies
- Animal Disease Management and Epidemiology
- Ear and Head Tumors
- Reproductive System and Pregnancy
- Vector-Borne Animal Diseases
- Tissue Engineering and Regenerative Medicine
- CRISPR and Genetic Engineering
- Laser Applications in Dentistry and Medicine
- Breast Implant and Reconstruction
Capital Medical University
2012-2025
Beijing Friendship Hospital
2016-2025
Shandong Academy of Agricultural Sciences
2014-2024
University of South China
2024
Chongqing Medical University
2024
Children's Hospital of Chongqing Medical University
2024
Qinghai Provincial Peoples Hospital
2023
Chongqing University
2020
Chongqing Three Gorges Central Hospital
2020
Peking University People's Hospital
2015
Graphene films, fabricated by chemical vapor deposition (CVD) method, have exhibited superiorities in high crystallinity, thickness controllability, and large-scale uniformity. However, most synthesized graphene films are substrate-dependent, usually fragile for practical application. Herein, a freestanding film is prepared based on the CVD route. By using etchable fabric substrate, papyraceous (FS-GFF) obtained. The electrical conductivity of FS-GFF can be modulated from 50 to 2800 Ω sq-1...
Background: Oriental people usually have a wide midface and prominent zygoma. Reduction malarplasty is one of the most frequently requested procedures for improvement facial contour in Orient. Some methods involve coronal or preauricular incision osteotomy, but this increases likelihood skin scars injury to nerves, duration surgery. an intraoral approach cannot control degree reduction precision interosseous fixation with designed osteotomy lines. The authors L-shaped malar prominence...
ABSTRACT Background Hearing loss (HL) significantly impacts quality of life and economic status worldwide. Chronic inflammation is suggested to influence hearing, yet the connection with inflammation‐related indexes in general population not well understood. Methods This cross‐sectional study analyzed data from 7231 adults six cycles (2005–2012 2015–2018) National Health Nutrition Examination Survey (NHANES). It examined correlation between systemic immune‐inflammatory biomarkers (NLR, SII,...
The ratio of non-high-density lipoprotein cholesterol to high-density (NHHR) is a novel lipid measure for assessing the risk cardiovascular disease. Lipid metabolism disorders are reportedly associated with hearing impairment. This study aimed investigate potential association between NHHR and hearing. data used in this were obtained from National Health Nutrition Examination Survey (NHANES) cycles 2005–2010 2017–2018, including 4,296 participants aged 6–19 years. was calculated profiles,...
Abstract Background Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and mitochondrial oxidative damage play important roles in occurrence progression aging. The D-galactose (D-gal)-induced aging model well widely utilized research. Our previous demonstrate administration D-gal causes subsequent dysfunction cochlear ribbon synapses, which turn leads to changes early stage...
Impairments of the inner ear result in sensorineural hearing loss and vestibular dysfunction humans. A large proportion these disorders are congenital, involve both auditory systems. Therefore, genetic interventions to correct deficits must be administered during early developmental stages. In this study, we evaluated gene transfer neonatal mice by canalostomy using an adeno-associated virus serotype 8 (AAV8) vector. AAV8 with green fluorescence protein (GFP) was inoculated into through...
The endoplasmic reticulum (ER) plays an essential role in Ca 2+ concentration balance and protein biosynthesis. During infection, the virus needs to complete its life process with help of ER. At same time, ER also produces stress (ERS), which induces apoptosis resist infection. Our study explored concentration, ERS, mechanism after porcine circovirus 2 (PCV2) We show here that PCV2 infection increased cytoplasmic level PK-15 cell swelling. colocalization phospholipase C (PLC) inositol...
This study aimed at reseaching the immune effect of porcine circovirus type 2 (PCV2) DNA vaccine containing CpG motif on mice. A total 40 6-week-old female BALB/c mice were randomly divided into four groups which immunized by 18CpG-pVAX1-ORF2, pVAX1-ORF2, pVAX1 and PBS, respectively, again weeks later. All challenged with 0.2 mL PCV2 cells virulent strain SD (106.0 TCID50/mL) after 4 weeks. Average daily gain, blood antibody levels, microscopic changes viremia detected to estimate vaccine....
Background: Microglia-mediated neuroinflammation is a hallmark of neurodegeneration. Metabotropic glutamate receptor 8 (GRM8) has been reported to promote neuronal survival in neurodegenerative diseases, yet the effect GRM8 on still unclear. Calcium overload-induced endoplasmic reticulum (ER)-mitochondrial miscommunication trigger brain. The aim this study was investigate putative anti-inflammatory effects microglia, specifically focusing its role calcium ER stress and mitochondrial...
Although tongue cancer is a common disease of the head and neck, choice neck treatment between elective dissection "watchful waiting" remains controversial for patients with early stage N0 oral carcinoma.On basis current state cancers decision analysis model was created to compare two strategies cancer. Expected value (EV) calculated according literature which met defined criteria. Sensitivity analyses were performed.The results showed that favored (EV = 0.87), over 0.77). One-way...
Abstract PCV2 belongs to the genus Circovirus, family Circoviridae, who is recognized as causative agents of postweaning multisystemic wasting syndrome. Since being found China in 2000, it has caused serious damage pig industry. In this study, we downloaded 40 genome‐wide sequences uploaded GenBank from 2013 2018 Shandong Province, including 23 by our laboratory. Construction a evolution tree using MEGA V5.0 software. Phylogenetic analysis indicated that genotype Province was: three...
Tinnitus is a common auditory disease worldwide; it estimated that more than 10% of all individuals experience this hearing disorder during their lifetime. sometimes accompanied by loss. However, loss not acquired in some other tinnitus generations. In study, we injected adult rats with salicylate sodium (SS) (200 mg/kg/day for 10 days) and found no significant threshold changes at 2, 4, 8, 12, 14, 16, 20, or 24 kHz (all p > 0.05). was confirmed the treated via Behaviour Testing Acoustic...
Nowadays, adjuvant is still important for boosting immunity and improving resistance in animals. In order to boost the of porcine circovirus type 2 (PCV2) DNA vaccine, CpG motifs were inserted. this study, dose–effect was studied, PCV2 vaccines by recombinant open reading frame (ORF2) gene evaluated. Three-week-old Changbai piglets inoculated intramuscularly with 200 μg, 400 800 μg containing 14 18 motifs, respectively. Average gain rectum temperature recorded everyday during experiments....
Objective To improve the diagnostic criteria of suspected cases through investigating epidemiological and clinical manifestations confirmed new-type coronavirus infection in children. Methods We retrospective analyzed 6 children with new diagnosed Chongqing Three Gorges Central Hospital from February 3, 2020 to 15, . Compared cases,we summarized problems encountered application this standard work try put forward Suggestions for improvement. Results Among cases: 5 males 1 female;...