A5101466599- Hearing, Cochlea, Tinnitus, Genetics
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neural Engineering
- Sleep and Wakefulness Research
- Vestibular and auditory disorders
- Ion channel regulation and function
- Biochemical effects in animals
- Sirtuins and Resveratrol in Medicine
- Obstructive Sleep Apnea Research
- Antioxidants, Aging, Portulaca oleracea
- Thyroid Disorders and Treatments
- Ion Channels and Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Thermal Regulation in Medicine
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Advanced Nanomaterials in Catalysis
- Platelet Disorders and Treatments
- Hydrogen's biological and therapeutic effects
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Medicinal Plants
- Traditional Chinese Medicine Analysis
Sun Yat-sen University
2023-2025
University of Glasgow
2025
Capital Medical University
2021-2024
Shenzhen Maternity and Child Healthcare Hospital
2023-2024
Hangzhou Normal University
2024
Beijing Friendship Hospital
2021-2024
Wenzhou Medical University
2022-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Tongde Hospital of Zhejiang Province
2020
Human humoral immune responses to SARS-CoV-2 vaccines exhibit substantial inter-individual variability and have been linked vaccine efficacy. To elucidate the underlying mechanism behind this variability, we conducted a genome-wide association study (GWAS) on anti-spike IgG serostatus of UK Biobank participants who were previously uninfected by had received either first dose (n = 54,066) or second 46,232) COVID-19 vaccines. Our analysis revealed significant associations between antibody...
Obstructive sleep apnea-hypopnea syndrome (OSAHS), typically characterized by chronic intermittent hypoxia (CIH), is associated with neurocognitive dysfunction in children. Sulforaphane (SFN), an activator of nuclear factor E2-related 2 (Nrf2), has been demonstrated to protect against oxidative stress various diseases. However, the effect SFN on OSAHS remains elusive. In this research, we investigated neuroprotective role CIH-induced cognitive and underlying mechanisms regulation Nrf2...
Evidence suggests that damage to the ribbon synapses (RS) may be main cause of auditory dysfunction in noise-induced hearing loss (NIHL).Oxidative stress is implicated pathophysiology synaptic damage.However, relationship between oxidative and RS NIHL remains unclear.To investigate hypothesis a key factor within inner ear, we conducted study using mice subjected single or repeated noise exposure (NE).We assessed function brainstem response (ABR) test examined cochlear morphology by...
Recent high-throughput experiments unveil substantial electrophysiological diversity among uncoupled healthy myocytes under identical conditions. To quantify inter-cell variability, the values of a subset parameters in well-regarded mathematical model action potential rabbit ventricular are estimated from fluorescence voltage measurements large number cells. Statistical inference yields population nearly 1200 cell-specific variants that, on population-level replicate experimentally measured...
Recent high-throughput experiments unveil substantial electrophysiological diversity among uncoupled healthy myocytes under identical conditions. To quantify inter-cell variability, the values of a subset parameters in well-regarded mathematical model action potential rabbit ventricular are estimated from fluorescence voltage measurements large number cells. Statistical inference yields population nearly 1200 cell-specific variants that, on population-level replicate experimentally measured...
Gestational diabetes mellitus, a heritable metabolic disorder and the most common pregnancy-related condition, remains understudied regarding its genetic architecture potential for early prediction using data. Here we conducted genome-wide association studies on 116,144 Chinese pregnancies, leveraging their non-invasive prenatal test sequencing data detailed records. We identified 13 novel loci gestational mellitus 111 five glycemic traits, with minor allele frequencies of 0.01-0.5 absolute...
Platelet count reduction occurs throughout pregnancy, with 5% to 12% of pregnant women being diagnosed gestational thrombocytopenia (GT), characterized by a more marked decrease in platelet during pregnancy. However, the underlying biological mechanism behind these phenomena remains unclear. Here, we used sequencing data from noninvasive prenatal testing 100 186 Chinese individuals and conducted, our knowledge, hitherto largest-scale genome-wide association studies on counts 5 periods...
Abstract Background Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and mitochondrial oxidative damage play important roles in occurrence progression aging. The D-galactose (D-gal)-induced aging model well widely utilized research. Our previous demonstrate administration D-gal causes subsequent dysfunction cochlear ribbon synapses, which turn leads to changes early stage...
The aim of the present study was to examine effects butorphanol on neural injury in an oxygen glucose deprivation/reoxygenation (OGD/R) model using PC12 cells, and investigate whether mitochondrial apoptosis involved these effects. To establish OGD/R model, cells were cultured under hypoxia low conditions. Expression levels inflammatory cytokines evaluated by detecting tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6 monocyte chemoattractant protein‑1. Oxidative stress measuring reactive...
Mitochondrial oxidative stress is involved in hair cell damage caused by noise-induced hearing loss (NIHL). Sirtuin-3 (SIRT3) plays an important role survival regulating mitochondrial function; however, the of SIRT3 NIHL unknown. In this study, we used 3-TYP to inhibit and found that inhibition aggravated cells mice with NIHL. Moreover, reduced enzymatic activity deacetylation levels superoxide dismutase 2 (SOD2). Subsequently, administered adeno-associated virus-SIRT3 posterior semicircular...
Age-related hearing loss (ARHL) is much more prevalent with age, affecting not only peripheral but central auditory system. We have previously established an aging model of system in vitro using cultured cochlear basilar membrane. However, there no ideal accelerated on vitro. To establish the model, cortical neurons (ACNs) were primary and treated either vehicle or different doses D-galactose (D-gal). studied effect D-gal ACNs by evaluating hallmarks aging, including cell proliferation,...
Adeno-associated virus (AAV)-mediated gene transfer is an efficient method of over-expression in the vestibular end organs. However, AAV has limited usefulness for delivering a large gene, or multiple genes, due to its small packaging capacity (< 5 kb). Co-transduction dual-AAV vectors can be used increase delivery various organs and tissues. not been well validated sensory epithelium. In present study, we characterized co-transduction mouse utricles following inoculation two...
Abstract Background Uncoupling protein 2 (UCP2), activated by excessive reactive oxygen species (ROS) in vivo, has the dual effect of reducing ROS to protect against oxidative stress and ATP production regulate cellular metabolism. Both UCP2 are increased cochleae age-related hearing loss (ARHL). However, role sensory hair cells ARHL remains unclear. Methods Male C57BL/6 J mice were randomly assigned an 8-week-old group (Group 1), a 16-week-old 2), + adeno-associated virus-inner ear (AAV-ie)...
Wumei Pills originates from Treatise on Cold Damage. A total of 128 records it were screened out, involving 102 ancient books, 110 modern clinical studies, and 48 diseases. According to the records, prescription origin, composition, explanation, main indications, dosage, medicinal processing, preparation, usage, contraindications, mo-dern applications analyzed. The result shows that is composed Mume Fructus, Asari Radix et Rhizoma, Zingiberis Coptidis Angelicae Sinensis Radix, Aconiti...
Thyroid hormones (TH) play a crucial role in promoting regular growth and differentiation, regulating energy metabolism, facilitating the physiological functions of nearly all human tissues. Previous studies have demonstrated that inter-individual variability thyroid hormone concentrations can be largely attributed to genetic influences. However, most genome-wide association primarily focused on European populations, with limited research involving East Asians. are particular importance...
Abstract Maintaining normal thyroid function is crucial in pregnancy, yet dysfunction and the presence of peroxidase antibodies (TPOAb) affect 0.5% to 18% pregnant women. Here, we conducted a genome-wide association study (GWAS) eight traits, including two thyroid-related hormones, four dysfunctions, autoimmunity measurements among 85,421 Chinese women investigate genetic basis during pregnancy. Our identified 176 loci, 125 previously unknown associations. Joint epidemiological Mendelian...