A5043819343- Hearing, Cochlea, Tinnitus, Genetics
- Cerebral Venous Sinus Thrombosis
- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Cyclopropane Reaction Mechanisms
- Vascular Malformations Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Traditional Chinese Medicine Analysis
- Synthesis and Catalytic Reactions
- Hearing Loss and Rehabilitation
- Trigeminal Neuralgia and Treatments
- Neural dynamics and brain function
- Neurosurgical Procedures and Complications
- Chromatography in Natural Products
- Meningioma and schwannoma management
- Dynamics and Control of Mechanical Systems
- Ear and Head Tumors
- Advanced Sensor and Energy Harvesting Materials
- Medicinal Plants and Neuroprotection
- Natural Antidiabetic Agents Studies
- Cardiovascular Syncope and Autonomic Disorders
- Soft Robotics and Applications
- Gout, Hyperuricemia, Uric Acid
Beijing Friendship Hospital
2016-2025
Capital Medical University
2015-2025
Center for Life Sciences
2023
Peking University
2023
Czech Academy of Sciences
2020
Czech Academy of Sciences, Institute of Physiology
2020
University of Michigan
2010-2019
Nankai University
2011-2017
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2015-2016
Beijing Tongren Hospital
2011-2016
Abstract An easily available iron catalyst was developed to accomplish the CH functionalization of indoles with α‐aryl‐α‐diazoesters in high yields under mild conditions. The asymmetric also realized by using complexes chiral spiro bisoxazolines up 78% ee .
An asymmetric N–H insertion of α-diazoesters with anilines catalyzed by well-defined copper complexes chiral spiro bisoxazoline ligands was studied in detail. The copper-catalyzed a wide range α-alkyl-α-diazoacetates accomplished excellent enantioselectivity (up to 98% ee) and provided an efficient method for the preparation optically active α-amino acid derivatives. A correlation study electronic properties substrates reaction supports stepwise mechanism, significant first-order kinetic...
We report the first intramolecular enantioselective cyclopropanation of indoles, which was accomplished in good to high yield (up 94%) with excellent enantioselectivity >99.9% ee) by using copper or iron complexes chiral spiro bisoxazolines as catalysts. This reaction is a straightforward, efficient method for constructing polycyclic compounds an all-carbon quaternary stereogenic center at 3-position indole skeleton, core structure shared numerous natural products and bioactive compounds.
An enantioselective synthesis of pharmaceutically important spirobarbiturates has been achieved via spirocyclic chiral phosphine-catalyzed asymmetric [4 + 2] annulation barbiturate-derived alkenes with allenoates. With the use this tool, various spirobarbiturate-cyclohexenes are obtained in good to excellent yields diastereo- and enantioselectivities. A wide range α-substituted allenoates were tolerated.
Origami has been proved as a valuable tool to develop deployable, multifunctional, and tunable devices for diverse engineering applications. Inspired by the Kresling origami, this article presents soft pneumatic actuator with vacuum control realize compound motion of twist contraction. The direction varies crease angle changes it offers pure contraction after combining two actuators reverse creases. Our can lift 180 folds its weight achieve ratio 47%, while response time is below 0.3 s....
Highly flexible and environmentally adaptive soft robots have received considerable attention. There remains a demand for to realize the stiffness modulation variable workspace robust versatile manipulations. This article presents compact gripper with polylactic acid-based module (VSM) rigid retractable mechanism achieve soft-rigid hybrid actuation. The can enhance its by 18-fold without sacrificing flexibility due VSM. A heating circuit is designed divide VSM into three regions. Each region...
The first regioselective catalytic asymmetric [3 + 2] cycloaddition of benzofuranone-derived olefins with allenoates and substituted has been developed in the presence (<italic>R</italic>)-SITCP.
The first enantioselective Nazarov cyclization of substrates with only one coordinating site and proton-transfer as an enantioselective-determining step was realized by means cooperative catalysis a Lewis acid chiral Brønsted acid.
Conclusions: CT angiography (CTA) and digital subtraction (DSA) are valuable tools in imaging work-ups for the diagnosis of sigmoid sinus diverticulum (SSD) wall dehiscence (SSWD). The development pulsatile tinnitus (PT) resulting from SSD SSWD may be associated with dominance venous systems. Objective: Our goal was to evaluate clinical characteristics PT caused by SSWD. Methods: This a retrospective chart review undertaken tertiary academic referral center. Fifty-four patients due were...
Abstract BACKGROUND The relationship between trans-stenotic blood flow velocity differences and the cerebral venous pressure gradient (CVPG) in transverse sinus (TS) stenosis (TSS) has not been studied. OBJECTIVE To evaluate hemodynamic manifestations of TSS CVPG. METHODS Thirty-three patients with idiopathic intracranial hypertension (IIH) or pulsatile tinnitus (PT) who had undergone diagnostic venography using manometry were included patient group. volunteers no symptoms control All 2...
To evaluate clinical characteristics and present surgical outcomes of PT caused by sigmoid sinus wall dehiscence (SSWD).This study retrospectively reviewed 34 patients with who were diagnosed SSWD in our institution between December 2008 July 2013. Among them, 27 underwent reconstruction (surgery group) 7 refused surgery (non-surgery group). Preoperative data obtained from the patients' medical records. All followed up regularly for at least 25 months. postoperative computed tomography...
Abstract The aim of this study was to use a combination physiologically based pharmacokinetic (PBPK) modeling and urinary glucose excretion (UGE) predict the time profiles pharmacokinetics (PK) UGE for sodium‐glucose cotransporter 2 (SGLT2) inhibitor empagliflozin (EMP). Additionally, aims explore compensatory effect SGLT1 in renal reabsorption (RGR) when SGLT2 is inhibited. PBPK‐UGE model developed using physicochemical biochemical properties, physiological parameters, binding kinetics,...
Migraine sufferers potentiate their visual evoked potentials (VEPs) from a short period of 2 min to longer 15 min. As lack habituation is linked higher level arousal, we thus hypothesized that short-term VEP potentiation might be correlated with an arousal-related personality trait. We therefore carried out VEPs, Plutchik-van Praag's Depression Inventory, Zuckerman's Sensation-Seeking Scales (Form V), and Zuckerman-Kuhlman's Personality Questionnaire in 26 healthy subjects, 22 patients...
The sigmoid sinus diverticulum (SSD) is an increasingly recognized cause of pulsatile tinnitus (PT). Surgical reconstruction the wall has been found to be highly effective for SSD; however, surgical techniques still need refined reduce incidence serious postoperative complications. Moreover, scrutinizing more cases SSD desirable establishing diagnostic criteria and standardizing technique. This study was retrospectively undertaken in 28 patients who were diagnosed with upon computed...
Local delivery of therapeutic drugs into the inner ear is a promising therapy for diseases. Injection through semicircular canals (canalostomy) has been shown to be useful approach local drug ear. The goal this article describe, in detail, surgical techniques involved canalostomy both adult and neonatal mice. As indicated by fast-green dye adeno-associated virus serotype 8 with green fluorescent protein gene, facilitated broad distribution injected reagents cochlea vestibular end-organs...
Animal-based studies have provided important insights into the structural and functional consequences of noise exposure on cochlea. Yet, less is known about molecular mechanisms by which induces cochlear damage, particularly at relatively low levels. While there ample evidence that leads to changes in inner ear metabolism, specific effects metabolome are poorly understood. In this study we applied liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS)-based metabolomics analyze...
Based on compelling experimental and clinical evidence, the fruit of Lycium ruthenicum Murr. (LRM), a unique traditional Tibetan medicine, exerts beneficial effects ameliorating learning memory deficits Alzheimer's disease (AD) other neurodegenerative disorders. However, potential active constituents biological mechanism LRM are still unknown. In this study, major chemical were first analyzed by ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap tandem mass...
Aged related decline of inner ear function contributes to both hearing loss and balance disorders, which lead impaired quality life falls that can result in injury even death. The cellular mechanisms responsible for the ear's functional have been controversial, but hair cell has considered key cause a long time. However, recent studies showed cochlea, synapses precedes or neuronal loss, this synaptopathy is an early step decline. Whether similar process occurs vestibular organ, its timing...
Abstract Objectives To investigate the correlation between transverse sinus stenosis (TSS) and transstenotic pressure gradient (TPG) in unilateral pulsatile tinnitus (PT) patients with sigmoid wall anomalies (SSWA). Methods Fifty-seven venous PT were retrospectively included. All of them underwent CT venography catheter manometry, accompanied SSWA. The degree, length, shape (intrinsic/extrinsic/dysplasia), location (proximal/middle/distal, referring to relative position TSS Labbé vein...
(1) Purpose: This study aimed to develop a physiologically based pharmacokinetic (PBPK) model predict the trough concentration (Ctrough) of imatinib (IMA) at steady state in patients and explore role free (fup), α1-acid glycoprotein (AGP) level, organic cation transporter 1 (OCT1) activity/expression clinical efficacy. (2) Methods: The population PBPK was built using physicochemical biochemical properties, metabolizing transporting kinetics, tissue distribution, human physiological...
Abstract Purpose To compare the diagnostic sensitivity of ultra-high-resolution computed tomography (U-HRCT) and HRCT in isolated fenestral otosclerosis (IFO). Methods A retrospective analysis was conducted on 85 patients (85 ears) diagnosed with IFO between October 2020 November 2022. U-HRCT (0.1 mm thickness) performed for 20 ears, (0.67 45 both ears. The images were evaluated by general radiologists neuroradiologists who blinded to diagnosis surgical information. detecting compared two...