A5019319203- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- Asymmetric Synthesis and Catalysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Synthetic Organic Chemistry Methods
- Asymmetric Hydrogenation and Catalysis
- Radical Photochemical Reactions
- Crystallography and molecular interactions
- Fluorine in Organic Chemistry
- Chemical Synthesis and Analysis
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Synthesis and Biological Activity
- Advanced Synthetic Organic Chemistry
- Catalytic Cross-Coupling Reactions
- Axial and Atropisomeric Chirality Synthesis
- Click Chemistry and Applications
- Multicomponent Synthesis of Heterocycles
- Organic Chemistry Cycloaddition Reactions
Chinese Academy of Sciences
2016-2025
Shanghai Institute of Organic Chemistry
2016-2025
University of Chinese Academy of Sciences
2016-2025
Kunming University of Science and Technology
2025
East China University of Science and Technology
2012-2025
Hunan University of Science and Technology
2025
Lanzhou Jiaotong University
2024
University of Shanghai for Science and Technology
2023-2024
Chongqing University
2015-2024
Xianning Central Hospital
2023
Catalytic asymmetric synthesis has received considerable attention over the past few decades, becoming a highly dynamic area of chemical research with significant contributions to field organic synthesis. In development new catalysts, concept multifunctional catalysis described by Shibasaki and co-workers, namely, combination more than one functional group within single molecule activate transformation, proved powerful strategy in design efficient transition metal-containing catalysts. A...
Asymmetric annulation of allenes with electron-deficient olefins and imines is one the most important reactions for synthesis optically active carbo- heterocycles, which are useful building blocks natural products medicinally substances. The use chiral phosphines as enantioselective catalysts can be envisaged such cyclizations. This article focuses on developments concerning asymmetric annulations unsaturated partners in recent decades perspectives that these new offer.
The discovery of Lu's [3 + 2] cycloaddition reaction is briefly introduced, and the recent important developments synthetic applications are highlighted overviewed.
Although they are highly strained, methylenecyclopropanes (MCPs) readily accessible molecules that have served as useful building blocks in organic synthesis. MCPs can undergo a variety of ring-opening reactions because the release cyclopropyl ring strain (40 kcal/mol) provide thermodynamic driving force for and π-character bonds within cyclopropane afford kinetic opportunity to initiate ring-opening. Since 1970s, chemistry has been widely explored presence transition metal catalysts, but...
Significant progress in the development of Morita–Baylis–Hillman (MBH) reaction has been made past decade. Many new variations MBH have well exploited, affording unexpected products and novel cyclized adducts some cases, known as "abnormal reactions". The formation abnormal MBHadducts depends on nature substrates employed catalytic system. This article will summarize recent advances mechanistic insights into such "abnormal" reactions, including double-MBH sila-MBH aza-MBH reactions tandem pathways.
The latest advances in the field of gold-catalyzed divergent synthesis carbo- and heterocycles are highlighted this Perspective. These reactions, which can provide structurally novel heterocycles, were achieved with good product selectivities, through subtle choice substrates, catalysts, ligands, counterions. related reaction mechanisms also discussed.
Phosphine-catalyzed highly regio- and diastereoselective [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with isatylidene malononitriles has been disclosed to give the corresponding spirocyclopenteneoxindoles in excellent yields under mild conditions. A plausible reaction mechanism also proposed on basis previous literature.
An interesting phosphine-containing Lewis base catalyzed highly regioselective [3 + 2] cycloaddition and a novel nitrogen-containing geometric selective [4 of isatin derived α,β-unsaturated diesters with α-allenic ester have been disclosed to give the corresponding cyclic products in good excellent yields under mild conditions. A plausible reaction mechanism has also proposed on basis previous literature our own investigation.
Stereo- and regioselective construction of poly-heterocycles, especially those with several contiguous stereocenters, is still a challenge. In this paper, catalyst-dependent stereodivergent synthesis indole-fused heterocycles through formal cycloadditions indolyl-allenes has been developed. The reaction features total reversion an all-carbon quaternary stereocenter when gold or platinum complex was employed as the catalyst [3 + 2] cycloaddition allene indole, affording different...
A novel asymmetric [4+1] annulation of MBH carbonates with dicyano-2-methylenebut-3-enoates has been developed for the first time, providing an efficient and enantioselective synthesis highly functionalized cyclopentenes bearing one all-carbon quaternary stereogenic center.
The asymmetric [4+1] annulation of activated α,β-unsaturated ketones with MBH carbonates catalyzed by bifunctional thiourea-phosphine catalysts derived from an axially chiral binaphthyl scaffold has been developed, giving spirooxindoles two adjacent quaternary stereocenters in good yields high enantioselectivities and moderate diastereoselectivities under mild conditions.
A Pd-catalyzed formal [5 + 3] intermolecular cycloaddition reaction of isatin-derived α-(trifluoromethyl)imines with aryl substituted vinylethylene carbonates (VECs) has been reported, affording trifluoromethyl-group-containing spirooxindoles fused an eight-membered ring as a single diastereoisomer in good yields the presence Brønsted acid one-pot manner under mild conditions. The asymmetric version this also realized using chiral phosphine ligand along further transformation obtained...
Carbocyclic and heterocyclic compounds could be constructed through the palladium-catalyzed annulation reactions of zwitterionic π-allyl palladium or propargyl complexes with unsaturated electrophiles.
A novel phosphine-catalyzed highly diastereoselective [3+2] cycloaddition of isatin derived α,β-unsaturated ketones with α-allenic ester has been developed.
D-Threonine-L-tert-leucine-derived bifunctional phosphine, Cat. 11, catalyzed highly enantioselective [3+2] annulation of maleimides with allenes has been disclosed, allowing the synthesis optically active functionalized bicyclic cyclopentenes containing two tertiary stereogenic centers in good to high yields along enantioselectivities.
The asymmetric catalytic aza-Morita–Baylis–Hillman (aza-MBH) reaction of isatin-derived ketimines with MVK has been established by using chiral amino and phosphino catalysts. resulted in biomedically important 3-substituted 3-amino-2-oxindoles good yields (>80% for most cases) excellent enantioselectivity (90–99% ee). Twenty-eight cases assembled quaternary stereogenic centers have examined under convenient systems.
A novel asymmetric formal [3+2] cycloaddition of vinyl cyclopropanes and isatins in the presence Pd2(dba)3 chiral imidazoline-phosphine ligand (aS,R,R)-L3 has been developed, affording corresponding highly functionalized oxindole-fused spirotetrahydrofuran frameworks good yields along with diastereo- high enantioselectivities under mild conditions.