A5049626822- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- MicroRNA in disease regulation
- Aortic aneurysm repair treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Conducting polymers and applications
- Coronary Interventions and Diagnostics
- Biochemical Analysis and Sensing Techniques
- Electronic Packaging and Soldering Technologies
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
- Copper Interconnects and Reliability
- Circular RNAs in diseases
- Vascular Procedures and Complications
- Mesenchymal stem cell research
- RNA modifications and cancer
- Aortic Disease and Treatment Approaches
- Ferroptosis and cancer prognosis
- Peripheral Artery Disease Management
- Nausea and vomiting management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biochemical and Structural Characterization
- Heme Oxygenase-1 and Carbon Monoxide
- Nitric Oxide and Endothelin Effects
Affiliated Hospital of Youjiang Medical University for Nationalities
2025
University of South China
2025
Second Hospital of Shandong University
2025
Harbin Medical University
2009-2024
Qilu Hospital of Shandong University
2023
Shandong University
2021-2023
Wuhan No.1 Hospital
2023
Zhuhai People's Hospital
2021
Dalian Medical University
2021
First Affiliated Hospital of Harbin Medical University
2009-2020
Abstract Equilibrioception (sensing of balance) is essential for mammals to perceive and navigate the three-dimensional world. A rapid mechanoelectrical transduction (MET) response in vestibular hair cells crucial detecting position motion. Here, we identify G protein-coupled receptor (GPCR) LPHN2/ADGRL2, expressed on apical membrane utricular cells, as maintaining normal balance. Loss LPHN2 specifically impaired both balance behavior MET mice. Functional analyses using hair-cell-specific...
Structures of prostaglandin receptor EP2 revealed its agonists’ selectivity and G protein coupling mechanism.
Myeloid derived suppressor cells (MDSC) are very important in tumor immune evasion and they dramatically increased peripheral blood of patients with osteosarcoma cancer. The association between MDSC various cytokines has been studied the blood. However, little is known about mechanism drawing into parenchyma. This study was to analyze correlation subsets interleukin 18 (IL-18) level model its effect on immunotherapy. were isolated from parenchyma analyzed model. IL-18 levels detected by...
Increasing reports demonstrated that dysregulated expression of microRNAs (miRNAs) leads to the progression various tumors. Previous studies revealed miR-328-3p exhibited in types However, its function and underlying mechanism osteosarcoma (OS) are still unexplored.The tissues OS cell lines was detected by qRT-PCR analysis. The effects proliferation were analyzed MTT assay. apoptosis cells examined colony formation assay TUNEL staining respectively. migration tumor ability measured wound...
Transplantation of bone-marrow-derived mesenchymal stem cells (MSCs) has been used to treat spinal cord injury (SCI) enhance tissue repair and neural cell regeneration. Glial line derived neurotrophic factor (GDNF) is an identified growth survival factor. Here, we examined whether modification GDNF levels in MSCs may further increase the potential promoting regeneration subsequently therapeutic outcome.We mRNA protein human by RT-qPCR Western blot, respectively. Bioinformatics analyses were...
Microcystin-LR (MC-LR) a cyclic toxin produced by cyanobacterial species is known to exert detrimental effects on various organs, including lung. Several investigators demonstrated that MC-LR exerts pulmonary toxicity, but the underlying mechanisms remain unclear. This study aimed investigate whether exposure MC-LR-induced lung inflammation and examine mechanisms. Thirty specific pathogen-free (SPF) male mice were allocated into control treatment groups. Mice intraperitoneally injected with...
Senile osteoporosis is closely related to the loss of function stem cells. In this study, we tried investigate potential secretome from human umbilical cord-derived mesenchymal cells (hUCMSCs) in recovering cell ability senescence and then delaying bone loss. We first harvested marrow-derived (BMSCs) young old rats compared their cellular characteristics such as growth, anti-senescence differentiation. The results showed that these abilities were negatively affected by animal aging....
Photopharmacology can be implemented in a way of regulating drug activities by light-controlling the molecular configuations. Three photochromic ligands (PCLs) that bind on one or two sites GABARs and nAChRs were reported here. These multiphoton PCLs, including FIP-AB-FIP, IMI-AB-FIP, IMI-AB-IMI, are constructed with an azobenzene (AB) bridge covalently connects fipronil (FIP) imidacloprid (IMI) molecules. Interestingly, three PCLs as well FIP IMI showed great insecticidal against
Abstract One difference between a low‐pressure plasma treatment and an atmospheric pressure is that in the atmosphere, substrate material may contain significant quantities of moisture, which could potentially influence effects treatment. To investigate how existence moisture affects treatment, aramid fibers (Twaron 1000) with three different regains (0.5, 4.5, 5.5%) were treated by jet for 3 s at gas flow rate 8 L/min, head temperature 100°C, power 10 W. The scanning electron microscopy...
Osteosarcoma is the most frequent primary bone tumor originating from adolescents and young adults. Despite improvements in chemo- or radio- therapy of osteosarcoma patients, survival rate has not increased drug resistance becomes a major factor that limits effectiveness. Therefore, investigation new treatment modalities urgently required to optimize therapeutic options. Our previous study described an oncogenic role miR-214 through promotion cells proliferation. In this study, we report...
Background: General anesthesia (GA), which is routinely applied in patients who undergo percutaneous endoscopic interlaminar lumbar discectomy (PEILD) of L5-S1 disc herniation, closely associated with postoperative cognitive dysfunction (POCD) the elderly. Local (LA) an alternative pain control protocol that has not yet been fully evaluated. Objectives: To evaluate feasibility LA PEILD compared GA. Study Design: A retrospective study. Setting: This study took place at First Affiliated...
The ankle-link complex (ALC) consists of USH2A, WHRN, PDZD7, and ADGRV1 plays an important role in hair cell development. At present, its architectural organization signaling remain unclear. By establishing Adgrv1 Y6236fsX1 mutant mice as a model the deafness-associated human Y6244fsX1 mutation, authors show here that mutation disrupts interaction between adhesion G protein-coupled receptor V subfamily member 1 (ADGRV1) other ALC components, resulting stereocilia disorganization...
OBJECTIVE: To study the correlation between single nucleotide polymorphism (SNP) of hsa-miR-124a and risk prognosis osteosarcoma (OS). METHODS: OS patients (n = 174) hospitalized at The Second Affiliated Hospital Harbin Medical University from January 2010 to March 2012 were selected as case group by inclusion exclusion criteria, healthy people 150) receiving physical examination same duration recruited control group. Polymerase chain reaction-ligase detection reaction (PCR-LDR) was...
The development of a small diameter (≤5 mm) arterial prosthesis requires the appropriate selection materials, structure and fabrication method so as to provide adequate mechanical properties, superior biocompatibility precise control over diameter. In this study, 100% polyester, silk fibroin combination both yarns were woven into seamless tubular prototype prostheses with different basic weaves. After degumming/scouring they met target inner 3.9±0.3 mm which demonstrates that weaving is way...
Compliance mismatch between stent graft and host artery may induce complications blood flow disorders. However, few studies have been reported on compliance. This study aims to explore the deformation compliance of in stented unstented zones under three pressure ranges. two grafts incorporated with polyurethane (nitinol-PU) polyester (nitinol-PET) materials respectively were tested; stents used identical. For circumferential each range, nitinol-PET was uniform both zones. The nitinol-PU...
Understanding neurite outgrowth, orientation, and migration is important for the design of biomaterials that interface with neural tissue. However, molecular signaling alternations have not been well elucidated to explain impact hydrogels on cell morphology. In our previous studies, a silk fibroin peptide (SF16) hydrogel was found be an effective matrix viability, morphology, proliferation PC12 rat pheocrhomocytoma cells. We cells in exhibited adhesive morphology compared those cultured...
The complication of stent graft‐induced new entry (SINE) after thoracic endovascular aortic repair (TEVAR) may be caused by the spring‐back force both ends grafts. Spring‐back force, which is exerted curvature and grafts on greater wall aorta, suggests poor flexibility. Research graft flexibility via design optimization has been widely disregarded. Thus, this study investigates relationship between structure measuring bending forces. Stent spacing (5, 10, 15 mm), apex angle (30° 45°), strut...