A5101672681- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Cancer Research and Treatments
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Phytoestrogen effects and research
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Risks and Factors
- Urinary Bladder and Prostate Research
- Gastric Cancer Management and Outcomes
- Protein Hydrolysis and Bioactive Peptides
- Biosensors and Analytical Detection
- Reproductive Biology and Fertility
- Bioenergy crop production and management
- Inflammatory mediators and NSAID effects
- Virus-based gene therapy research
- RNA Research and Splicing
- Cancer-related gene regulation
- Renal and related cancers
- Ubiquitin and proteasome pathways
- Sperm and Testicular Function
- Kidney Stones and Urolithiasis Treatments
Chongqing Medical University
2010-2023
Dalian Medical University
2010-2023
Second Affiliated Hospital of Chongqing Medical University
2010-2023
In this study, we examined the antitumor effects of Puerarin (PEU) on androgen-independent (DU145 and PC-3) androgen-dependent (LNCaP) prostate cancer cells, explored its potential mechanisms. Supplement with PEU (2.5 μM, 5 10 μM) exhibited a marked inhibitory effect against growth DU145 PC-3 especially beyond 24 h, whereas there is only slight LNCaP cells at high concentration μM 72 h. This loss cell viability in by was mediated induction apoptosis via up-regulation Bax cleaved-caspase-3,...
Glutathione S-transferase P1 (GSTP1) is an important phase II enzyme involved in the metabolism of xenobiotics and whose polymorphisms have been related to individual cancer risks. The objective this study was explore association GSTP1 A1578G (Ile105Val) polymorphism with susceptibility clinicopathologic characteristics bladder a Chinese population.We investigated distribution 200 patients age- sex-matched cancer-free controls. were analyzed using polymerase chain reaction-restriction...
Increasing evidence has indicated that abnormal epigenetic factors such as RNA m6A modification, histone DNA methylation, binding proteins and transcription are correlated with hepatocarcinogenesis. However, it is unknown how modification-associated genes contribute to the occurrence clinical outcome of hepatocellular carcinoma (HCC). Thus, we constructed models may enhance diagnosis prognosis HCC.In this study, focused on value for HCC. Our gene expression data were collected from TCGA HCC...
This work focused on investigating the relation of centromeric protein A (CENPA) gene expression with prognosis papillary renal cell carcinoma (PRCC).We obtained data from PRCC cases in TCGA. Thereafter, CENPA levels between paired and matched non-carcinoma samples were analyzed by Wilcoxon rank-sum test, while relations clinicopathological characteristics level examined logistic regression test. The prognostic value was assessed plotting receiver operating feature curve (ROC) calculating...
BACKGROUND:Tyrosine kinase inhibitors (TKIs) are used to treat metastatic disease associated with clear cell renal carcinoma (ccRCC); however, most patients develop resistance after 6 15 months. As such, identifying biomarkers of TKI may be useful for prognosis. MATERIAL AND METHODS:We analyzed ChIP-seq data related from the Gene Expression Omnibus and RNA-Seq clinical The Cancer Genome Atlas database. We univariate Cox analysis regression/Lasso determine a risk score. Kaplan-Meier estimate...
Abstract The present work aimed to screen biomarkers associated with Chromophobe cell carcinoma of kidney(chrcc)by bioinformatics methods as key genes predict the prognosis chrcc.The GSE15641 dataset was acquired from Gene Expression Omnibus(GEO) database, Totally 1153 differentially expressed (DEGs) were identified.thereafter, DEGs detected carry out Ontology (GO) annotation and Kyoto Encyclopedia Genome (KEGG) pathway enrichment analysis. Moreover, protein-protein interaction (PPI)...
Abstract Objective: To analyze expression levels, prognostic value and immune infiltration association of Holliday junction protein (HJURP) as well its feasibility a pan-cancer biomarker for different cancers. Methods: The Protter online tool was utilized to obtain the structure localization HJURP in diverse tumors, then mutation methylation tumors were further explored. Thereafter, mRNA data clinical characteristics 33 tumor types from TCGA database obtained investigating levels within...