A5001027380- Arsenic contamination and mitigation
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Acute Myeloid Leukemia Research
- Heavy Metal Exposure and Toxicity
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Dye analysis and toxicity
- Parasites and Host Interactions
- Protein Tyrosine Phosphatases
- Biochemical and Molecular Research
- Medical Research and Treatments
- Eosinophilic Disorders and Syndromes
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Sinusitis and nasal conditions
- Angiogenesis and VEGF in Cancer
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2024
Chongqing Medical University
2020-2024
Hainan General Hospital
2023
Guiyang Medical University
2007
Inorganic arsenic (iAs) is a well-known human carcinogen recognized by the World Health Organization and International Agency for Research on Cancer. Currently, most iAs studies in populations are concerned with drinking water occupational arsenicosis. In Guizhou province, arsenicosis caused burning of coal unventilated indoor stoves an unusual type exposure. Because poisoning mechanism involved as yet unknown no effective therapy exists, progress has been slow prevention
Hepatocellular carcinoma (HCC) is a highly vascularized tumor with poor prognosis. Novel vascular-related therapeutic targets and prognostic markers remain urgently needed.To investigate the role mechanism of CLCA1 in hepatocellular carcinoma.Immunofluorescence, Co-immunoprecipitation rescue experiment were used to determine specific mechanisms CLCA1. Chemosensitivity assay was measure impact on Sorafenib.CLCA1 dramatically downregulated cell lines tissues. Ectopic expression induced...
Abstract Background Nasopharyngeal carcinoma tends to present at an advanced stage because the primary anatomic site is located in a less visible area and its clinical symptoms are nonspecific. Prognosis of nasopharyngeal cases remains disappointing. SEPT9 methylation-based biomarker approved by US Food Drug Administration for colorectal cancer screening diagnosis. Interestingly, downregulation SEPT9, especially SEPT9_v2, mediated promoter hypermethylation has been also detected head neck...
Increasing evidence has indicated that abnormal epigenetic factors such as RNA m6A modification, histone DNA methylation, binding proteins and transcription are correlated with hepatocarcinogenesis. However, it is unknown how modification-associated genes contribute to the occurrence clinical outcome of hepatocellular carcinoma (HCC). Thus, we constructed models may enhance diagnosis prognosis HCC.In this study, focused on value for HCC. Our gene expression data were collected from TCGA HCC...
Laryngeal squamous cell cancer (LSCC) is a common malignant tumor with high degree of malignancy, and its etiology remains unclear. Therefore, screening potential biomarkers necessary to facilitate the treatment diagnosis LSCC. Robust rank aggregation (RRA) analysis was used integrate two gene expression datasets LSCC patients from Gene Expression Omnibus (GEO) database identify differentially expressed genes (DEGs) between nonneoplastic tissues. A coexpression network constructed using...
Background: The occurrence of nasal polyps is related to mucosal barrier damage. role MG53, an important epithelial repair regulator, in remains unclear. This study aimed investigate the MG53 repair. Methods: We divided patients into following three groups (n=15 each): chronic rhinosinusitis without (CRSsNP), with (CRSwNP) and septal deviation (control). performed qRT-PCR western blotting determine expression TGF-β1, Smad2/3, zonula occluden-1 (ZO-1), collagen-a1 (Col-a1) tissues human cells...
Background: SCARA5 may play an important role in nasopharyngeal carcinoma. Materials & methods: PCR and immunohistochemistry were used to detect the expression promoter methylation of SCARA5. Cell proliferation assays, spheroid culture, flow cytometry analysis, Transwell assays xenotransplantation tests utilized determine functional effects RNA-sequencing, western blotting, immunofluorescence dual-luciferase reporter assess SCARA5-mediated outcomes. Results: was downregulated by methylation....
Abstract Background Colorectal cancer (CRC) is one of the major cancers in world. Spi-B Transcription Factor (SPIB) member E-twenty-six (ETS) transcription factor family. Previous studies have shown that expression SPIB down-regulated human colorectal tissues. However, its biological function cells not reported. The purpose our study to explore and related mechanism cells, provide reference for molecular detection targeted drug therapy cancer. Methods were studied by colony formation assay,...
7086 Background: Polycythemia vera (PV), a myeloproliferative disorder associated with JAK2V617F mutation, is characterized by erythrocytosis due to dysregulated red blood cell (RBC) production. We investigated the hypothesis that RBC accumulation results from increased precursor proliferation and/or apoptosis resistance abnormal signaling via MAPK and PI3K/AKT pathways. Methods: Peripheral CD34+ cells were grown in liquid culture generate primary erythroid precursors (EBLs) PV patients...