A5038683523- Nanoplatforms for cancer theranostics
- Kruppel-like factors research
- Cancer-related gene regulation
- Luminescence and Fluorescent Materials
- Plant Molecular Biology Research
- Advanced Nanomaterials in Catalysis
- Plant Reproductive Biology
- Photodynamic Therapy Research Studies
- Photosynthetic Processes and Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Hemostasis and retained surgical items
- Pancreatitis Pathology and Treatment
- Protein Tyrosine Phosphatases
- Liver Disease and Transplantation
- Colorectal Cancer Treatments and Studies
- Electrospun Nanofibers in Biomedical Applications
- Wnt/β-catenin signaling in development and cancer
- Graphene and Nanomaterials Applications
- GABA and Rice Research
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- TGF-β signaling in diseases
- Rice Cultivation and Yield Improvement
- Immune cells in cancer
Guangxi Medical University
2020-2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2008-2021
Chongqing Medical University
2008-2021
Sichuan Agricultural University
2017-2020
Rice Research Institute
2017-2020
Abstract Hypoxia severely impedes photodynamic therapy (PDT) efficiency. Worse still, considerable tumor metastasis will occur after PDT. Herein, an organic superoxide radical (O 2 ∙− ) nano‐photogenerator as a highly effcient type I photosensitizer with robust vascular‐disrupting efficiency to combat these thorny issues is designed. Boron difluoride dipyrromethene (BODIPY)‐vadimezan conjugate (BDPVDA) synthesized and enwrapped in electron‐rich polymer‐brushes methoxy‐poly(ethylene...
Reactive oxygen species (ROS), acting as essential mediators in the biological system, highly influence physiologic and pathologic processes of human body. The aberrant production ROS, caused by various diseases, may lead to inflammation cellular damages, well homeostasis disruption. In recent years, biomaterials sensitive stimuli have received increasing attention due their potential for achieving more specific diagnoses effective treatments. Particularly, ROS-responsive could be triggered...
In various reactive oxygen species (ROS)-based antitumor approaches (e.g., photodynamic therapy), increasing attentions are made to improve ROS level, but the short lifetime that is another decisive hurdle of ROS-based outcomes not even explored yet. To address it, a photocleaved O2 -released nanoplatform constructed release and switch into nitrogen (RNS) for repressing hypoxic breast tumor. Systematic explorations validate nanoplatforms can attain continuous photocontrolled release,...
Abnormal epigenetic regulation is identified to correlate with cancer progression and renders tumor refractory resistant reactive oxygen species (ROS)-based anti-tumor actions. To address it, a sequential ubiquitination phosphorylation epigenetics modulation strategy developed exemplified by the well-established Fe-metal-organic framework (Fe-MOF)-based chemodynamic therapy (CDT) nanoplatforms that load 26S proteasome inhibitor (i.e., MG132). The encapsulated MG132 can blockade proteasome,...
Male fertility is crucial for rice yield, and the improvement of yield requires hybrid production that depends on male sterile lines. Although recent studies have revealed several important genes in reproductive development, our understanding mechanisms pollen development remains unclear. We identified a mutant oslap6 with complete phenotype caused by defects exine formation. By using MutMap method, we found single nucleotide polymorphism (SNP) variation located second exon OsLAP6/OsPKS1 was...
Postoperative bleeding and infection are the main causes of death. Although a commercial zeolite-represented hemostatic agent has been widely used, zeolite-induced thermal damages to tissues unresolved, antibacterial wound healing desirably demanded but challenging. Herein, composite zeolite-based hemostat spray consisting Ag-doped β zeolite (Ag-βZ) coupled fibrinogen/thrombin (F/T) developed seal postsurgical blood burst. Systematic experiments reveal that F/T can be switched into fibrin...
The transcription factor, zinc-finger protein 545 (ZNF545), that belongs to the Kruppel-associated box (KRAB-ZFP) family, acts as a tumor suppressor and is inactivated by promoter methylation in cancers such nasopharyngeal carcinoma, breast cancer, gastric but its role colorectal cancer (CRC) unknown. purpose of this study was characterize ZNF545 expression, status, biological function, related molecular mechanisms CRC. results showed expressed adult normal tissues, downregulated or silenced...
Pollen fertility is an agronomic trait that strongly influences rice yield. Recent studies have revealed the development of pollen wall required for and regulated by several genes. However, mechanisms underlying in remain largely unknown. In present study, a point mutation gene on chromosome 1 was identified resulted production less shrunken (LSP) led to defects formation. This named LSP1 found encode member adenosine triphosphate-binding cassette (ABC) transporter G subfamily, OsABCG3. Two...
Background: The cadherin-11 (CDH11, OB-cadherin) gene is a member of the cadherin family and located on chromosome 16q22.1. Previous studies have revealed that cadherins play significant roles in development many human malignancies. Increasing evidence has identified CDH11 as functional tumour suppressor, which commonly silenced by promoter methylation, but functions this colorectal cancer (CRC) been unclear. Methods: expression primary CRC tissues cell lines was investigated qRT-PCR, RT-PCR...
Objective: To assess the role of ascitic endocan levels in diagnosis spontaneous bacterial peritonitis (SBP) decompensated cirrhosis.Methods: Ascites samples, as well demographic and laboratory data, were collected at admission from patients with cirrhosis. Ascitic endocan, tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) measured by ELISA. The influencing factors SBP, correlation other inflammatory indicators, diagnostic value for SBP analyzed.Results: A total 167 enrolled, 39 group...
Hybrid rice significantly contributes to the food supply worldwide. Backbone parents play important roles in elite hybrid breeding systems. In this study, we performed pedigree-based analysis of backbone parent variety, namely, Shuhui 527 (SH527, Oryza sativa), exploit key genome regions during breeding. Twenty-four cultivars (including SH527, its six progenitors and 17 derived cultivars) were collected analyzed with high-density single nucleotide polymorphism (SNP) array. Scanning all these...
Abstract Background Colorectal cancer (CRC) is one of the major cancers in world. Spi-B Transcription Factor (SPIB) member E-twenty-six (ETS) transcription factor family. Previous studies have shown that expression SPIB down-regulated human colorectal tissues. However, its biological function cells not reported. The purpose our study to explore and related mechanism cells, provide reference for molecular detection targeted drug therapy cancer. Methods were studied by colony formation assay,...