A5100634747- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Retinal Diseases and Treatments
- Carbon and Quantum Dots Applications
- Graphene and Nanomaterials Applications
- Genomics and Chromatin Dynamics
- Mycobacterium research and diagnosis
- Epigenetics and DNA Methylation
- Advanced Glycation End Products research
- Neurogenesis and neuroplasticity mechanisms
- Cancer Mechanisms and Therapy
- Lipid metabolism and disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical and Molecular Research
- Circular RNAs in diseases
- Advanced Nanomaterials in Catalysis
- Tuberculosis Research and Epidemiology
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Ginseng Biological Effects and Applications
Kunming Medical University
2014-2022
First Affiliated Hospital of Kunming Medical University
2014-2022
Beijing Chest Hospital
2015
Capital Medical University
2015
Abstract Increasing evidence has shown that microRNAs (miRNAs) play an important role in the pathogenesis of diabetic retinopathy (DR). However, and mechanism miRNA regulating high glucose (HG)-induced ARPE-19 cell injury are still not well understood. The present study aimed to investigate effects miR-200a-3p on DR progression reveal underlying mechanisms their effects. In study, we observed was significantly decreased, while transforming growth factor-β2 (TGF-β2) expression up-regulated...
The incidence of gliomas is increasing. Although great progress in glioma treatment has been made, the clinical outcome remains unsatisfactory. Chemokine (C-C motif) ligand 2 (CCL2) plays a key role different types cancers, including glioma. However, function CCL2 chemoresistance not fully understood. In current study, was significantly upregulated More importantly, and CCR2 were temozolomide (TMZ)-resistant TMZ-resistant malignant glioblastoma cells (U251/TMZ) had higher expressions level...
Abstract Gliomas account for about 80% of malignant brain tumors. The incidence a new tumor is 6.4 per 100,000 persons year with an overall 5‐year survival rate 33.4%. Regardless the great advances that have been made in recent years, causes and pathogenesis glioma remain unclear. Here we study how phosphoglycerate mutase 4 (PGAM4) contributes to glioma. Using variety methods examine cell viability, proliferation, apoptosis, glycolysis, as well ChIP coanalysis modified histone H3, showed...
Abstract This study aimed to find potential diagnostic biomarkers for diabetic retinopathy (DR) , explore its ceRNA mechanism and analyze the role of immune cell infiltration in DR. Method. Three microarray datasets human retina tissues aqueous humor DR were downloaded from Gene Expression Omnibus (GEO) database. First, differentially expressed miRNAs (DE-miRNAs) mRNAs (DE-mRNAs) identified by R software. Then xCell ImmuCellAI used evaluate cells tissues. BioGPS was identify...
Abstract The circular RNAs (circRNA) are becoming more important in cancer development. However, the functional role of circRNA glioblastoma is still remain to be deeply studied. In current study, we used CCK-8, flow cytometry, transwell, western blot, and RT-PCR assays determine expression has_circ_0008344 different glioma cells. Results showed that level hsa_circ_0008344 cells was remarkably higher than normal HCGC Down-regulation significantly decreased proliferation rate, increased...