A5030913107- Circular RNAs in diseases
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Galectins and Cancer Biology
- interferon and immune responses
- Lymphoma Diagnosis and Treatment
- Extracellular vesicles in disease
- GDF15 and Related Biomarkers
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- ATP Synthase and ATPases Research
- Endoplasmic Reticulum Stress and Disease
- Phagocytosis and Immune Regulation
- Recommender Systems and Techniques
- Cardiac electrophysiology and arrhythmias
- Signaling Pathways in Disease
- Energy Harvesting in Wireless Networks
- Glycosylation and Glycoproteins Research
Sir Run Run Shaw Hospital
2024-2025
Zhejiang University
2024-2025
Xuzhou Medical College
2025
First Affiliated Hospital of Kunming Medical University
2017-2024
Kunming Medical University
2017-2024
Nanjing Medical University
2021-2023
Jiangsu Province Hospital
2021-2023
Xidian University
2020-2023
Temple University
2012-2021
Xi'an Technological University
2021
Abstract Remote ischaemic preconditioning (RIPC) is well known to protect the myocardium against ischaemia/reperfusion injury (IRI). Exosomes are small extracellular vesicles that have become key mediators of intercellular communication. Various studies confirmed circulating exosomes mediate RIPC. However, underlying mechanisms for RIPC-induced exosome-mediated cardioprotection remain elusive. In our study, we found expression level miR-24 was higher in derived from plasma rats subjected...
Chimeric antigen receptor (CAR) T cells are emerging as a novel treatment for patients with refractory/relapsed B-cell non-Hodgkin lymphoma (B-NHL), and combination PD1 inhibitors may further improve the efficacy of anti-CD19 CAR (CD19 CAR)-T in lymphomas. In single-center study, we evaluated safety therapy CD19 CAR-T an anti-PD-1 antibody (nivolumab) relapsed/refractory B-NHL. A total 11 B-NHL were recruited subsequently received nivolumab. The primary end points feasibility. infusions...
Nuclear receptors (NRs) can regulate gene expression; therefore, they are classified as transcription factors. Despite the extensive research carried out on NRs, still several issues including (1) expression profile of NRs in human tissues, (2) how NR is modulated during atherosclerosis and metabolic diseases, (3) overview role inflammatory conditions not fully understood. To determine whether regulated physiological/pathological conditions, we took an experimental database analysis to all...
Background: Low-intensity ultrasound (LIUS) was shown to be beneficial in mitigating inflammation and facilitating tissue repair various pathologies. Determination of the molecular mechanisms underlying anti-inflammatory effects LIUS allows optimize this technique as a therapy for treatment malignancies aseptic inflammatory disorders. Methods: We conducted cutting-edge database mining approaches determine exerted by LIUS. Results: Our data revealed following interesting findings: 1) are...
Caspase-1 is present in the cytosol as an inactive zymogen and requires protein complexes named "inflammasomes" for proteolytic activation. However, it remains unclear whether activity of caspase-1 confined only to where inflammasomes are assembled convert pro-caspase-1 active caspase-1. We conducted meticulous data analysis methods on proteomic, interaction, intracellular localization, gene expressions 114 experimentally identified substrates 38 interaction proteins normal physiological...
There is increasing clinical evidence to suggest a suppressive effect on hematopoiesis in myelodysplastic syndrome patients with iron overload. However, how overload influences (MDS) remains unknown. Here, the RUNX1S291fs-transduced bone marrow mononuclear cells were yielded and transplanted into lethally irradiated recipient mice together radioprotective generate MDS mice. Eight weeks post transplantation, received an intraperitoneal injection of 0.2 mL dextran at concentration 25 mg/mL...
It is well established that caspase-1 exerts its biological activities through downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various knockout tissues indicated can significantly impact the transcriptome. However, it not known whether all effects exerted by on transcriptome are mediated only well-known substrates. Therefore, we hypothesized of may be partially independent To determine new global tissue-specific gene regulatory caspase-1, took novel...
We mined novel uremic toxin (UT) metabolomics/gene databases, and analyzed the expression changes of UT receptors synthases in chronic kidney disease (CKD) cardiovascular (CVD). made following observations: 1) UTs represent only 1/80th human serum small-molecule metabolome; 2) Some are increased CKD CVD; 3) either induce or suppress inflammatory molecules; 4) The genes is significantly modulated patients, coronary artery (CAD) patients; 5) upregulated by caspase-1 TNF-alpha pathways but...
We took an experimental database mining analysis to determine the expression of 28 co-signaling receptors in 32 human tissues physiological/pathological conditions. made following significant findings: 1) are differentially expressed tissues; 2) heart, trachea, kidney, mammary gland and muscle express that mediate CD4+T cell functions such as priming, differentiation, effector, memory; 3) urinary tumor, germ leukemia chondrosarcoma high levels for T activation; 4) inflammasome components...
Circular RNAs (circRNAs) play a critical role in the modulation of tumor metabolism. However, expression patterns and metabolic function circRNAs chronic lymphocytic leukemia (CLL) remain largely unknown. This study aimed to elucidate lipid metabolism CLL.The cohort 53 patients with CLL were investigated using whole transcriptome sequencing. Cell viability, liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis, Nile red staining as well triglyceride (TG) assay used evaluate...
The ever-growing Internet of Things (IoT) provides a powerful means for complex and changeable environmental monitoring. Directional sensor networks (DSNs), as typical architecture IoT, can efficiently facilitate various digital intelligent IoT applications. In the DSNs, due to asymmetry in coverage focus diversity detection angle directional sensors, how enhance performance with limited sensors becomes new challenge. To this end, we develop novel redeployment scheme based on minimum...
Objection: Cumulative studies have identified the effectiveness of cardiac shock wave therapy (CSWT) in treating heart failure after acute myocardial infarction (AMI), but little been discussed with regard to beneficial effects CSWT on anti-fibrosis along underlying mechanism. In this study, we investigated whether could reduce post-AMI fibrosis and further explored molecular Methods: Rat (HF) models induced by ligating left anterior descending coronary artery were established validated...
Abstract Background Extrachromosomal circular DNAs (eccDNAs), a type of double‐stranded (dsDNAs) that facilitate the activation DNA sensing machinery, have been implicated in progression and prognosis various diseases. While roles eccDNAs remain contentious, their significance diffuse large B‐cell lymphoma (DLBCL) has not reported. Methods Circular sequencing (circle‐seq) was used to demonstrate expression profile DLBCL, atomic force microscopy validate presence eccDNAs. CCK‐8 scRNA‐seq...