A5068206190- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Bioinformatics and Genomic Networks
- Pharmacological Effects of Natural Compounds
- Thyroid Cancer Diagnosis and Treatment
- Immune cells in cancer
- Lipid metabolism and disorders
- Diagnosis and Treatment of Venous Diseases
- Extracellular vesicles in disease
- Natural product bioactivities and synthesis
- Photoacoustic and Ultrasonic Imaging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatocellular Carcinoma Treatment and Prognosis
- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Machine Learning in Bioinformatics
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Lipoproteins and Cardiovascular Health
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Pelvic floor disorders treatments
Southern Medical University
2022-2025
Sun Yat-sen University
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Fujian Medical University
2024
Air Force Medical University
2012-2024
Shanxi Medical University
2022-2024
Shaanxi Provincial People's Hospital
2022-2024
Shaanxi Polytechnic Institute
2020-2024
Peking Union Medical College Hospital
2024
Shenyang Pharmaceutical University
2022-2023
Nuclear receptors (NRs) can regulate gene expression; therefore, they are classified as transcription factors. Despite the extensive research carried out on NRs, still several issues including (1) expression profile of NRs in human tissues, (2) how NR is modulated during atherosclerosis and metabolic diseases, (3) overview role inflammatory conditions not fully understood. To determine whether regulated physiological/pathological conditions, we took an experimental database analysis to all...
Prostate cancer (PCa) responds poorly to routine immunotherapy due the tumor immunosuppressive microenvironment. Here, we describe an ultrasound-based drug delivery strategy stimulate potent anti-tumor immunity via exosomes encapsulated with sonosensitizers Chlorin e6 (Ce6) and immune adjuvant R848, namely ExoCe6+R848. ExoCe6+R848 was constructed by simple co-incubation of Ce6 R848 HEK 293T cell-derived exosomes. The properties were not affected after loading accumulated in site intratumoral...
Background: Low-intensity ultrasound (LIUS) was shown to be beneficial in mitigating inflammation and facilitating tissue repair various pathologies. Determination of the molecular mechanisms underlying anti-inflammatory effects LIUS allows optimize this technique as a therapy for treatment malignancies aseptic inflammatory disorders. Methods: We conducted cutting-edge database mining approaches determine exerted by LIUS. Results: Our data revealed following interesting findings: 1) are...
Background Oxidative stress is a significant contributor to the development of various diseases, and oxidative balance score (OBS) valuable tool for assessing impact dietary lifestyle factors on in humans. Nevertheless, precise relationship between OBS thyroid function adults remains elusive. Methods This cross-sectional study comprised 6222 adult participants drawn from National Health Nutrition Examination Survey (NHANES) conducted 2007 2012. Employing weighted multivariable linear...
To investigate the feasibility of applying a new quantitative image analysis method to improve breast cancer diagnosis performance using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) by integrating background parenchymal enhancement (BPE) features into decision making process.A dataset involving 115 DCE-MRI examinations was used in this study. Each examination depicts one identified suspicious tumor. Among them, 75 cases were verified as malignant and 40 benign biopsy...
Two oat genes encoding hydroxycinnamoyl-CoA:hydroxyanthranilate N-hydroxycinnamoyltransferase (HHT) and S-adenosyl-l-methionine:trans-caffeoyl-CoA 3-O-methyltransferase (CCoAOMT), both of which are possibly involved in the biosynthesis avenanthramide phytoalexins, were cloned their expression profiles response to biological stress studied. Four distinct cDNAs HHT (AsHHT1-4) isolated with degenerative polymerase chain reaction method. The enzymatic activity AsHHT1 expressed E. coli was found...
We took an experimental database mining analysis to determine the expression of 28 co-signaling receptors in 32 human tissues physiological/pathological conditions. made following significant findings: 1) are differentially expressed tissues; 2) heart, trachea, kidney, mammary gland and muscle express that mediate CD4+T cell functions such as priming, differentiation, effector, memory; 3) urinary tumor, germ leukemia chondrosarcoma high levels for T activation; 4) inflammasome components...
The mechanisms underlying pathophysiological regulation of tissue macrophage (Mφ) subsets remain poorly understood. From the expression 207 Mφ genes comprising of: 31 markers for 10 subsets, 45 transcription factors (TFs), 56 immunometabolism enzymes, 23 trained immunity (innate immune memory) and 52 other in microarray data; we made following findings: 1) When grouping 34 inflammation diseases tumor types into eight categories there was differential TFs; highlighted by 12 shared 20...
This study aims to develop a novel segmentation method that utilizes spatio-temporal information for segmenting two-dimensional thyroid nodules on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Leveraging medical morphology knowledge of the gland, we designed semi-supervised model first segments guiding focus exclusively region. approach reduces complexity nodule by filtering out irrelevant regions and artifacts. Then, introduced explicitly extract temporal from DCE-MRI data...
<title>Abstract</title> <bold>Background:</bold> Cancers of the lower esophagus and esophagogastric junction (EGJ) are highly aggressive with poor prognoses. Minimally invasive Ivor–Lewis surgery (MIIL) is preferred, but anastomotic leakage remains a critical complication. This study introduces novel double-layered scallop-shaped anastomosis (DLSSA) technique compares its outcomes circular stapled (CSEA). <bold>Methods:</bold> From April 2016 to February 2023, 117 patients distal esophageal...
Receptor-interacting protein kinase 2 (RIPK2) has emerged as a promising drug target in various cancers, including prostate cancer (PC). However, the absence of reliable biomarkers to assess RIPK2 activity limits both patient selection for anti-RIPK2 therapies and treatment monitoring. To address this gap, we performed RNA-Seq analysis on PC cell lines (22Rv1, DU145, PC3) with CRISPR/Cas9-mediated knockout (RIPK2-KO) using two independent guide RNAs. This identified 13 candidate...
The aims of this study are to investigate the effects neurotransmitters NPY and CGRP on ERK signaling in fracture healing, identify correlation between macrophage aggregation healing.Male Sprague-Dawley rats were used build a model. neurotransmitter receptor inhibitors injected intraperitoneally into rats. Immunofluorescence staining ELISA employed determine expression area peripheral blood, respectively. Micro-CT together with histological utilized assess healing conditions. Relative...
<em>Paris</em> saponin H (PSH) is a type of steroid derived from Rhizoma Paridis (RP; the rhizome <em>Paris</em>). In our previous studies, saponins RP exerted antiglioma activity <em>in vitro</em>. However, effects PSH on glioma have not been elucidated. The aim present study was to evaluate U251 glioblastoma cells and elucidate possible underlying mechanism. were treated with at various concentrations for 48 h, cell viability, invasion, apoptosis cycle progression assessed using specific...
<b><i>Introduction:</i></b> Parkinson’s disease (PD) is the most common neurodegenerative worldwide. Studies have shown that insulin-like growth factor-binding protein 5 (IGFBP5) may contribute to methamphetamine-induced neurotoxicity and neuronal apoptosis in PC-12 cells rat striatum. Here, we studied expression role of IGFBP5 6-OHDA-toxicant model PD. <b><i>Methods:</i></b> SH-SY5Y were exposed 50 μ<sc>m</sc> 6-OHDA for 24 h....