A5070277287- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- Reconstructive Facial Surgery Techniques
- Circular RNAs in diseases
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Immune cells in cancer
- Melanoma and MAPK Pathways
- Intracerebral and Subarachnoid Hemorrhage Research
- Dermatological and Skeletal Disorders
- Intracranial Aneurysms: Treatment and Complications
- Pharmacogenetics and Drug Metabolism
- Orthopedic Infections and Treatments
- Systemic Sclerosis and Related Diseases
- Neurogenetic and Muscular Disorders Research
- Bone Metabolism and Diseases
- Ear Surgery and Otitis Media
Wuhan University
2021-2024
Renmin Hospital of Wuhan University
2021-2024
National Medical Research Center of Dentistry and Maxillofacial Surgery
2024
Huzhou University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Shenyang Medical College
2023
University of Alabama at Birmingham
2012
Yuncheng University
2010
Neuroinflammation and neuronal apoptosis are closely associated with a poor prognosis in patients subarachnoid hemorrhage (SAH). We investigated the role of C-C motif chemokine receptor 2 (CCR2) SAH.Pre-processed RNA-seq transcriptome datasets GSE167110 GSE79416 from Gene Expression Omnibus (GEO) database were screened for genes differentially expressed between mice SAH control mice, using bioinformatics analysis. The endovascular perforation model was performed to establish SAH. RS504393 (a...
Collagen type V alpha 1 chain (COL5A1) is a hypoxia-related gene (a collagen family protein) and participates in the formation of extracellular matrix. Although some evidence supports significant role for COL5A1 progression several cancers, pan-cancer analysis not currently available. Herein, we aimed to assess prognostic value 33 human cancers investigate its underlying immunological function. Through multiple bioinformatics methods, analyzed data from Oncomine, TCGA, CCLE, HPA, DNMIVD,...
Background: This study investigates the role of basic leucine zipper and W2 domain-containing 2 (BZW2) in endometrial cancer (EC) its implications for tumor progression patient outcomes. We assessed expression BZW2 (UCEC) correlation with progression, clinical pathological features, prognosis.Methods: utilized RNA sequencing data from TCGA UALCAN databases to analyze patterns EC association grade, stage, age, prognosis. Additionally, we explored molecular relationships between BZW2, various...
Dental caries, one of the most prevalent infectious diseases worldwide, affects approximately 80% children and majority adults. caries may result in endodontic disease, leading to dental pulp necrosis, periapical inflammation bone resorption, severe pain, tooth loss. Periapical also increase other parts body. Although many studies have attempted develop therapies for this there is still an urgent need effective treatments. In study, we applied a novel gene therapeutic approach using...
Abstract Aims Cell death, except for cuproptosis, in gliomas has been extensively studied, providing novel targets immunotherapy by reshaping the tumor immune microenvironment through multiple mechanisms. This study aimed to explore effect of cuproptosis on and its predictive power prognosis response. Methods Eight glioma cohorts were included this study. We employed unsupervised clustering algorithm identify clusters described their microenvironmental characteristics, mutation landscape,...
Cyclin-dependent kinase regulatory subunit 2 (CKS2) is a potential prognostic marker and overexpressed in various cancers. This study analyzed sequencing clinical data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus, with external validation using the Chinese Glioma (CGGA) data. CKS2 expression normal brain tumor tissue was compared. cBioPortal MethSurv were utilized to scrutinize value of methylation. set enrichment examination single-sample gene analysis employed explore...
Glioma is the most common primary brain tumor in human brain. The present study was designed to explore expression of PIMREG glioma and its relevance clinicopathological features prognosis patients. correlations with infiltrating levels immune cells response immunotherapy were also investigated. analyzed based on GEO, TCGA, HPA databases. Kaplan–Meier survival analysis used examine predictive value for patients glioma. correlation between using CIBERSORT algorithm TIMRE database. checkpoints...
CYP39A1 is a poorly characterized metabolic enzyme that has been investigated in few tumors. However, the role of hepatocellular carcinoma (HCC) not yet clarified. In this study, expression and clinical significance HCC were explored.CYP39A1 protein was detected Akt/c-Met-induced mice 14 paired fresh samples as well another 159 matched noncancerous tissues. Meanwhile, mRNA analyzed by GEO TCGA analysis validated Furthermore, relationships between clinicopathologic features prognosis...
Dendritic cells (DCs) are key mediators of transplant rejection. Numerous factors have been identified that regulate immunopathology by modulating the function DCs. Among these, microRNAs (miRNAs), small non-coding RNA molecules, received much attention. The miRNA miR-223 is very highly expressed and tightly regulated in hematopoietic cells. It plays an important role immune response regulating neutrophils macrophages, its dysregulation contributes to multiple types diseases. However,...
Liver hepatocellular carcinoma (LIHC) is a malignancy with high mortality and morbidity rate worldwide. However, the pathogenesis of LIHC has still not been thoroughly studied. Transmembrane coiled-coil domains 3 (TMCO3) encodes monovalent cation, member proton transducer 2 (CPA2) family transporter proteins. In present study, TMCO3 expression its relationship cancer prognosis, as well immunological role in were studied by bioinformatic analysis. We found significant overexpression TCGA,...
Auricular cartilage graft has a wide range of applications in plastic and reconstructive surgery. However, there is still risk absorption the grafts over time. Intrinsic postauricular fascia (IPF) with rich vascular network may play an important role nutrition repair auricular cartilage. This study aimed to investigate effect IPF on survival viability free grafts.
Glioma, the most prevalent primary brain tumor in adults, is characterized by significant invasiveness and resistance. Current glioma treatments include surgery, radiation, chemotherapy, targeted therapy, but these methods often fail to eliminate completely, leading recurrence poor prognosis. Immune checkpoint inhibitors, a class of commonly used immunotherapeutic drugs, have demonstrated excellent efficacy treating various solid malignancies. Recent research has indicated that...
This study aimed to explore the mechanisms of transient receptor potential (TRP) channels on immune microenvironment and develop a TRP-related signature for predicting prognosis, immunotherapy response, drug sensitivity in gliomas.
<p>Supplementary Figure S3. Kaplan-Meier plot of time to treatment failure</p>
<p>Supplementary Material</p>
Glioma is the common, most aggressive and poorest prognostic tumor type in brain. More more biomarkers associated with glioma treatment, prognosis, immunity are being discovered. Here, we aimed to explore underlying biological functions predictive value of Apolipoprotein L4 (APOL4) glioma. We downloaded expression data APOL4 clinical information from several databases used R software for preprocessing. The significance a outcome was explored by Cox regression analysis Kaplan–Meier survival...
It is critical to find efficient non-invasive prognostic factor for osteosarcoma. In this study, we demonstrated that serum protein of pro-surfactant B (pro-SFTPB) may be a potential diagnostic indicator in We found pro-SFTPB was highly expressed osteosarcoma patients and presented good value discern from non-osteosarcoma control subjects. Serum also significantly correlated with advanced clinical stage, distant metastasis, shorter overall survival. addition, an independent Overall, our study useful
Progressive hemifacial atrophy often causes lip vermilion defects in patients. In this study, we described a one-stage repair method for progressive using mucosal flap or combined dermal fat graft.Patients diagnosed with from 2010 to 2022 were included study. Based on the severity and location of patient's defect, was designed transferred defect hip morphology. Lip morphology function patients followed up after surgery.A total 22 enrolled including 15 upper alone 7 both lower defects....