A5085736815- Renal Transplantation Outcomes and Treatments
- MicroRNA in disease regulation
- Organ Transplantation Techniques and Outcomes
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Gut microbiota and health
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Clinical Nutrition and Gastroenterology
- Algal biology and biofuel production
- Photosynthetic Processes and Mechanisms
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Microbial Community Ecology and Physiology
- Cancer-related molecular mechanisms research
- Genetic diversity and population structure
- Cancer, Hypoxia, and Metabolism
- Genetic Syndromes and Imprinting
- Cell death mechanisms and regulation
- Plant and Fungal Species Descriptions
- Ubiquitin and proteasome pathways
- Kidney Stones and Urolithiasis Treatments
University of Electronic Science and Technology of China
2016-2024
Chinese Academy of Sciences
2022
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2018-2022
Chengdu Medical College
2020
Science and Technology Department of Sichuan Province
2018-2019
University of Pittsburgh
2019
American Heart Association
2016
Stanford University
2010-2014
Hainan Normal University
2009-2012
Southwest University
2012
Abstract Emerging evidence has revealed that aberrantly expressed circular RNAs (circRNAs) play vital roles in tumorigenesis and progression of diverse human malignancies. Although an existing literature elucidated the regulatory role circZNF609 breast cancer, crucial function exerted on hepatocellular carcinoma (HCC) remains unclear. Herein, we determined to explore molecular mechanism HCC. In this study, was conspicuously overexpressed featured with loop structure Functional tests...
MicrorRNA are small noncoding RNA molecules that regulate the posttranscriptional expression of target genes. In addition to being involved in many biologic processes, microRNAs important regulators innate and adaptive immune responses. Distinct sets expressed found different cell types tissues aberrant is associated with disease states. MicroRNA was examined a model heterotopic heart transplantation by microarray analyses unique profile detected rejecting allogeneic transplants (BALB/c →...
Abstract Liver hepatocellular carcinoma (LIHC) is the most common type of primary liver cancer. In current study, genome-wide miRNA-Seq and mRNA profiles in 318 LIHC patients derived from The Cancer Genome Atlas (TCGA) were analysed to identify miRNA-based signatures for prognosis with survival analysis a semi-supervised principal components (SPC) method. A seven-miRNA signature was confirmed overall (OS) prediction by comparing miRNA paired tumour solid normal tissues. Thereafter, linear...
Background/Aim: Intestinal damage induced by total body irradiation (TBI) reduces leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)-expressing stem cells, goblet, and Paneth breaching the epithelial lining, facilitating bacterial translocation, sepsis, death. Materials Methods: Survival was measured after TBI in animals that received wild-type or recombinant bacteria producing interleukin-22 (IL-22). Changes survival due to microbially delivered IL-22 were measured....
The present study evaluated the degree of differentiation between closely-related species Blyth's leaf warbler complex (Phylloscopus reguloides s.l.) and white-tailed davisoni by molecular (cytochrome b 16S rRNA) bioacoustic markers (sonagraphic analysis songs). Molecular phylogenetic results corroborate recently suggested splittings two former taxa into three species, respectively. By contrast to previous opinion, territorial songs parallels genetic diversification in both groups. In P....
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate the posttranscriptional expression of target genes and important regulators in immune responses. Previous studies demonstrated miRNA, miR-182 was significantly increased during allograft rejection. Further, transcription factor Forkhead box (FOX) protein 1, (FOXO1) shown to be a miR-182. The aim this study is further examine role alloimmune responses.Transplantation BALB/c cardiac allografts performed C57BL/6, miR-182,...
Efforts at finding potential biomarkers of tolerance after kidney transplantation have been hindered by limited sample size, as well the complicated mechanisms underlying and risk rejection immunosuppressant withdrawal. In this work, three different publicly available genome-wide expression data sets peripheral blood lymphocyte (PBL) from 63 tolerant patients were used to compare 14 machine learning models for their ability predict spontaneous graft tolerance. We found that Best Subset...
Objective Post‐transplantation diabetes mellitus (PTDM) is a common complication in renal transplant recipients (RTRs). Gut microbiome plays important roles variety of chronic metabolic diseases, but its association with the occurrence and development PTDM still unknown. The present study integrates analysis gut metabolites to further identify characteristics PTDM. Methods A total 100 RTRs fecal samples were collected our study. Among them, 55 submitted Hiseq sequencing, used for...
Background The kidney transplant recipients (KTRs) were diagnosed with Chronic Kidney Disease after transplantation (CKD-T). CKD-T can be affected by the microbial composition and metabolites. present study integrates analysis of gut microbiome metabolites to further identify characteristics CKD-T.Methods We collected 100 fecal samples KTRs divided them into two groups according stage progression CKD-T. Among them, 55 analyzed Hiseq sequencing, used for non-targeted metabolomics analysis....
Objective To investigate the association between graft‐derived cell‐free DNA and pretransplantation clinical variables, to determine whether former could be used as a novel biomarker predict renal function. Methods A total of 87 recipients who underwent primary kidney transplantation were recruited study. For each recipient, 10 mL peripheral blood was collected on days 1, 7, 14–20, 30–45 after transplantation. The fractional abundance determined using droplet digital polymerase chain...
There are four LhcII genes of Dunaliella salina have been submitted to the database GenBank. However, little is known about Lhca this green alga, although knowledge might be available study composition and phylogenesis Lhc gene family. Recently, one was cloned from alga D. by PCR amplification using degenerate primers. This cDNA, designated as DsLhca1, contains an open reading frame encoded a protein 222 amino acids with calculated molecular mass 27.8 kDa. DsLhca1 predicted contain three...
Interstitial fibrosis and tubular atrophy (IFTA) with inflammation (IFTA -I) is strongly correlated kidney allograft failure.Diagnosis of IFTA-I accurately early critical to prevent graft failure improve survival.In the current study, through analyzing renal biopsy in patients stable function after transplantation (STA), IFTA group semi-supervised principal components methods, we found that CD2, IL7R, CCL5 based signature could not only distinguish STA well, but predict a high degree...
The present diagnostic methods for detecting graft damage after kidney transplantation are either invasive or not available early enough. microRNAs (miRNAs) in peripheral blood mononuclear cells (PBMCs) have been suggested as promising biomarkers.Using quantitative real-time polymerase chain reaction, we identified 9 miRNAs (miR-142-5p, miR-142-3p, miR-223, miR-211, miR-486, miR-155, miR-10b, miR-30a, and let-7c) related to the human renal allograft status PBMCs from 104 transplant...
Dunaliella salina is a useful model for studying the respective roles of each LHCII protein at molecular level in extreme environmental conditions. However, information about LhcII genes D. very limited. In order to identify more salina, two additional cDNAs were obtained by screening cDNA library. The genomic DNA was amplified PCR using specific primer set corresponding 5′ and 3′ untranslated regions transcript. are obviously different from other; therefore they genes. Each gene contains an...
Glioma, the most prevalent primary brain tumor in adults, is characterized by significant invasiveness and resistance. Current glioma treatments include surgery, radiation, chemotherapy, targeted therapy, but these methods often fail to eliminate completely, leading recurrence poor prognosis. Immune checkpoint inhibitors, a class of commonly used immunotherapeutic drugs, have demonstrated excellent efficacy treating various solid malignancies. Recent research has indicated that...
Background The long-term graft survival is closely related to its early status, yet the indices for assessing status are complex and lack quantitative values. aim of this study investigate potential GcfDNA as a comprehensive, non-invasive, convenient, quantifiable indicator evaluating status. Methods In study, 138 recipients who underwent primary kidney transplantation were enrolled. Peripheral blood samples, each 10 mL, collected on days 1 7 post-transplantation. quantification both...