A5051607146- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- Animal Genetics and Reproduction
- RNA modifications and cancer
- Renal Transplantation Outcomes and Treatments
- Hippo pathway signaling and YAP/TAZ
- Cancer Genomics and Diagnostics
- Identification and Quantification in Food
- Cancer-related molecular mechanisms research
- Genetic Syndromes and Imprinting
- Mechanisms of cancer metastasis
- Cytomegalovirus and herpesvirus research
- Organ Transplantation Techniques and Outcomes
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- FOXO transcription factor regulation
- Cytokine Signaling Pathways and Interactions
- Kruppel-like factors research
- Hedgehog Signaling Pathway Studies
- Pancreatic function and diabetes
Peking University
2025
West China Medical Center of Sichuan University
2022-2024
Shenzhen Technology University
2024
Xi'an Jiaotong University
2024
Foshan University
2024
University of Electronic Science and Technology of China
2017-2023
Southern University of Science and Technology
2023
Jinan University
2023
Massachusetts General Hospital
2019-2023
Harvard University
2019-2023
Abstract The immune system plays an indispensable role in maintaining human health against the invasion of foreign materials, microorgainisms and pathogens. autoimmune diseases chronic inflammatory disorders are characterized by dysregulated responses resulting excessive uncontrolled tissue inflammation, as well tumour, others. In recent years, flavonoids widely recognized potentially natural polyphenol compounds for treatment multiple diseases, given their immunomodulatory activity,...
Abstract Background NDRG 2 (N-Myc downstream-regulated gene 2) was initially cloned in our laboratory. Previous results have shown that expressed differentially normal and cancer tissues. Specifically, mRNA down-regulated or undetectable several human cancers, over-expression of inhibited the proliferation cells. also exerts important functions cell differentiation tumor suppression. However, it remains unclear whether participates carcinogenesis thyroid. Methods In this study, we...
Background Efficient bedside neurofunctional monitoring is crucial for managing disorders of consciousness (DoC). Ultrafast Power Doppler Imaging (uPDI) outperforms traditional Ultrasound in assessing the microcirculatory system. However, intracranial blood flow imaging traditionally faces limitations due to skull’s impedance. This constraint circumvented common post-craniectomy DoC patients, who present a unique observational window uPDI. Methods We conducted uPDI scans on five patients...
WD repeat domain 3 (WDR3) is involved in a variety of cellular processes including gene regulation, cell cycle progression, signal transduction and apoptosis. However, the biological role WDR3 pancreatic cancer associated mechanism remains unclear. We seek to explore immune-independent functions relevant for cancer.The GEPIA web tool was searched, IHC assays were conducted determine mRNA protein expression levels patients. MTS, colony formation, transwell human cancer. Western blot analysis,...
MicroRNA-543 (miR-543) has been suggested as an important regulator of the development and progression various cancer types. However, role biological function miR-543 in clear cell renal carcinoma (ccRCC) remains unclear. Here, we found that expression was significantly increased tumor tissues from ccRCC patients lines. We overexpression markedly promoted proliferation invasion cells, whereas suppression had opposite effects. Krüppel-like factor 6 (KLF6) identified a target gene miR-543....
Osthole (7-methoxy-8-isoamyl alkenyl coumarin) has been reported to exhibit marked anticancer effects on several types of cancer. The expression levels matrix metalloproteinase-9 (MMP-9) are closely associated with the pathogenesis glioma. Furthermore, it is that upregulation microRNA‑16 (miR‑16) by MMP‑9 signaling pathway can restrain proliferation cancer cells. To examine whether osthole increases effect human glioma cells in present study, common cell line, U87, was treated at...
Erlotinib, a small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, demonstrated therapeutic efficacy against pancreatic cancer. However, acquired resistance to erlotinib in cancer is widely observed, and the exact mechanisms have not been fully explored until now. We examined role of circular RNA circ_0013587 cells underlying mechanisms. selected erlotinib-resistant from AsPC-1 cell line. The expression was by qRT-PCR assays. effects on proliferation, invasion,...
Anterior cruciate ligament injuries are common in humans, though cellular components of the knee have little regenerative or proliferation potential. This study investigated differentiation human amnion-derived mesenchymal stem cells (hAMSCs) into anterior fibroblasts (hACLFs) vitro through induction with bFGF and TGF-β1 coculture systems. Groups A B comprised hAMSCs at 3rd passage cultured without TGF-β1, respectively; C D consisted hACLFs monolayer E F were composed Transwell respectively....
Abstract Potato virus Y (PVY) is a globally and economically important pathogen of potato, tobacco, tomato other staple crops caused significant yield losses reductions in quality.To explore the molecular PVY-host interactions, we analysed changes miRNA mRNA profiles tobacco response to PVY infection. A total 81 differentially expressed miRNAs belonging 29 families 8133 mRNAs were identified. The Gene Ontology (GO) enrichment analyses showed that genes encoding DNA/RNA binding, catalytic...
Abstract Liver hepatocellular carcinoma (LIHC) is the most common type of primary liver cancer. In current study, genome-wide miRNA-Seq and mRNA profiles in 318 LIHC patients derived from The Cancer Genome Atlas (TCGA) were analysed to identify miRNA-based signatures for prognosis with survival analysis a semi-supervised principal components (SPC) method. A seven-miRNA signature was confirmed overall (OS) prediction by comparing miRNA paired tumour solid normal tissues. Thereafter, linear...
Metabolic dysregulation and disruption of immune homeostasis have been widely associated with perioperative complications including ischemic stroke. Although immunometabolite S-2-hydroxyglutarate (S-2HG) is an emerging regulator cells thus triggers the response, it unclear whether how S-2HG elicits brain injury exacerbates post-stroke cognitive dysfunction.Perioperative stroke was induced by transient middle cerebral artery occlusion for 60 min in C57BL/6 mice 1 day after ileocecal...
A protective intra-operative lung ventilation strategy has been widely recommended for laparoscopic surgery. However, there is no consensus regarding the optimal level of positive end-expiratory pressure (PEEP) and its effects during pneumoperitoneum. Electrical impedance tomography (EIT) recently introduced as a bedside tool to monitor in real-time.We hypothesised that individually titrated EIT-PEEP adjusted surgical intervention would improve respiratory mechanics after surgery.Randomised...
Ischemic stroke (IS), predominantly triggered by blockages in cerebral blood flow, is increasingly recognized as a critical public health issue. The combination of Salvia miltiorrhiza (SM) and Cortex moutan (CM), traditional herbs Eastern medicine, are frequently used for managing heart brain vascular conditions. However, the exact mechanisms which this herb pair (SC) combats IS remain largely unexplored. This investigation focuses on pinpointing active constituents SC that contribute to its...
Efforts at finding potential biomarkers of tolerance after kidney transplantation have been hindered by limited sample size, as well the complicated mechanisms underlying and risk rejection immunosuppressant withdrawal. In this work, three different publicly available genome-wide expression data sets peripheral blood lymphocyte (PBL) from 63 tolerant patients were used to compare 14 machine learning models for their ability predict spontaneous graft tolerance. We found that Best Subset...
B lymphocytes have long been recognized for their critical contributions to adaptive immunity, providing defense against pathogens through cognate antigen presentation T cells and Ab production. More recently appreciated is that are also integral in securing self-tolerance; this has led interest therapeutic application downregulate unwanted immune responses, such as transplant rejection. In study, we found PMA- ionomycin-activated mouse acquire regulatory properties following stimulation...
The aim of this study is to investigate the role CD147 in glucose metabolic regulation and its association with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment sensitivity prediction using 18 F‐fluorodeoxyglucose ( F‐FDG) PET/CT imaging non‐small cell lung cancer (NSCLC). In study, four human NSCLC lines different EGFR‐TKI responses were used detect p‐EGFR/EGFR expression via Western blotting flow cytometric analyses. Radioactive uptake F‐FDG by established...
For the purpose of efficient targeted therapies, suppressing phagocytosis by a mononuclear phagocyte system (MPS), enhancing "active" delivery, and meeting clinical production criteria are extremely critical for engineering strategies novel drug delivery systems. Herein, we used chemically-induced membrane blebbing extrusion combined method to induce triple-negative breast cancer (TNBC) cell apoptosis secrete apoptotic body analogue (ABA) vesicles on large scale therapeutic delivery. After...
Regulatory B cells (Bregs) have shown promise as anti-rejection therapy applied to organ transplantation. However, less is known about their effect on other cell populations that are involved in chronic graft rejection. We recently uncovered naïve cells, stimulated by TLR ligand agonists, converted into with regulatory properties (Bregs-TLR) prevented allograft Here, we examine the granular phenotype and of Breg-TLR suppressing cells. Cocultures Bregs-TLR LPS-activated showed a...