A5015345041- Xenotransplantation and immune response
- Pancreatic function and diabetes
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Animal Genetics and Reproduction
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Cytomegalovirus and herpesvirus research
- Metabolism, Diabetes, and Cancer
- Tissue Engineering and Regenerative Medicine
- Hippo pathway signaling and YAP/TAZ
- Immunotherapy and Immune Responses
- Molecular Biology Techniques and Applications
- Transplantation: Methods and Outcomes
- Lipid metabolism and disorders
- MXene and MAX Phase Materials
- Galectins and Cancer Biology
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2018-2025
University of Electronic Science and Technology of China
2015-2025
Massachusetts General Hospital
2021-2022
Harvard University
2021-2022
Science and Technology Department of Sichuan Province
2018
A porous honeycomb-like sulfur host was engineered using oxidized six-element HEA nanoparticles (MgCrMnFeCoNi–O), offering excellent lithium polysulfide adsorption ability and catalytic activity toward the conversion of species.
The present study was designed to examine the protective effect of notoginsenoside R1 (NR1) on podocytes in a rat model streptozotocin (STZ)‑induced diabetic nephropathy (DN), and explore mechanism responsible for NR1-induced renal protection. Diabetes induced by single injection STZ, NR1 administered daily at dose 5 mg/kg (low dose), 10 (medium) 20 (high) 16 weeks Sprague-Dawley rats. Blood glucose levels, body weight proteinuria were measured every 4 weeks, starting day that rats received...
Novel non-invasive biomarkers for gastric cancer (GC) are needed, because the present diagnostic methods GC either invasive or insensitive and non-specific in clinic. The presence of stable circulating microRNAs (miRNAs) plasma suggested a promising role as biomarkers.Based on quantitative droplet digital PCR (ddPCR), four miRNAs (miR-21, miR-93, miR-106a miR-106b) related to were identified from training cohort 147 participants validation 28 participants.All miRNA levels significantly...
Injury to terminally differentiated podocytes contributes ignificantly proteinuria and glomerulosclerosis. The aim of this study was examine the protective effects notoginsenoside R1 (NR1) on maintenance podocyte number foot process architecture via inhibition apoptosis, induction autophagy pf biology in target cells. NR1 conditionally immortalized human under high glucose conditions were evaluated by determining percentage expression levels slit diaphragm proteins. Our results revealed that...
Introduction Genetically edited pigs, modified using CRISPR-Cas9 technology, hold promise as potential sources for xenotransplantation. However, the optimal combination of genetic modifications and their expression levels initial clinical trials remains unclear. This study investigates generation TKO/hCD55/hTM/hEPCR (6GE) pigs evaluates compatibility with human immune coagulation systems. Methods The 6GE were generated through iterative genome editing F1 breeding. Genotyping, flow cytometry,...
Abstract Liver hepatocellular carcinoma (LIHC) is the most common type of primary liver cancer. In current study, genome-wide miRNA-Seq and mRNA profiles in 318 LIHC patients derived from The Cancer Genome Atlas (TCGA) were analysed to identify miRNA-based signatures for prognosis with survival analysis a semi-supervised principal components (SPC) method. A seven-miRNA signature was confirmed overall (OS) prediction by comparing miRNA paired tumour solid normal tissues. Thereafter, linear...
B lymphocytes have long been recognized for their critical contributions to adaptive immunity, providing defense against pathogens through cognate antigen presentation T cells and Ab production. More recently appreciated is that are also integral in securing self-tolerance; this has led interest therapeutic application downregulate unwanted immune responses, such as transplant rejection. In study, we found PMA- ionomycin-activated mouse acquire regulatory properties following stimulation...
Previous studies by our group on mangiferin demonstrated that it exerts an anti‑hyperglycemic effect through the regulation of cell cycle proteins in 3‑month‑old, partially pancreatectomized (PPx) mice. However, β‑cell proliferation is known to become severely restricted with advanced age. Therefore, unknown whether able reverse diabetic condition and retain regeneration capability aged In present study, 12‑month‑old C57BL/6J mice had undergone PPx were subjected treatment (90 mg/kg) for 28...
Regulatory B cells (Bregs) have shown promise as anti-rejection therapy applied to organ transplantation. However, less is known about their effect on other cell populations that are involved in chronic graft rejection. We recently uncovered naïve cells, stimulated by TLR ligand agonists, converted into with regulatory properties (Bregs-TLR) prevented allograft Here, we examine the granular phenotype and of Breg-TLR suppressing cells. Cocultures Bregs-TLR LPS-activated showed a...
Background: Currently, reducing the instant blood-mediated inflammatory reaction (IBMIR) and achieving long-term survival of transplanted pig islets can be enhanced by modifying single or multiple genes. However, optimal gene combination has not been determined. To address this issue, we utilized a simple in vitro model exposing neonatal different genotypes to human blood identify relationship between genotype IBMIR, thus facilitating screening for combination. Methods: Seven day-old pigs...
Background: Currently, pig islet xenotransplantation into the portal vein of monkeys is mostly performed by open surgery. However, in clinic, percutaneous transhepatic puncture under ultrasound guidance approach choice. Our goal was to compare cytokine inflammatory response associated with each method, order select optimal method. Methods: Islet donors were 2 years-old female pigs either GTKO or GTKO/CD55 genotype. Recipients 3-years-old rhesus monkeys. Monkeys underwent two operation...
School of Medicine University Electronic Science and Technology China. Clinical Immunology Translational Key Laboratory Sichuan Province. Introduction: This study aims to assess the ability machine learning (ML) classifiers which based on peripheral blood transcriptome data, a timely non-invasive approach, for classification patients with kidney allograft acute rejection (AR) stable function (STA) posttransplant. Materials Methods: 90 AR 72 STA patient pathological data updated Gene...
Organ transplantation-Sichuan Youth Science and Technology Innovation Research Team. Background: Although islet xenotransplantation has been proven to be a promising strategy for treatment of type 1 diabetes, it’s application in clinical setting would have overcome acute cellular rejection challenging species barrier. The aim this study was determine the role Foxp3+ regulatory T cells (Treg) anti-CD45RB induced dominant specific tolerance human mice. Methods: One thousand five hundred IEQ...