A5013449754- Immune Cell Function and Interaction
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
- Viral-associated cancers and disorders
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Diabetes Management and Research
- Virus-based gene therapy research
- Xenotransplantation and immune response
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022-2025
University of Electronic Science and Technology of China
2022-2025
N6-methyladenosine (m6A), the most prevalent form of internal mRNA modification, is extensively involved in Treg cells differentiation and function. However, involvement m6A functional for transplantation tolerance remains to be elucidated. By using an experimental mouse model, we found that levels were altered during induction transplant by performing a dot blotting assay. Subsequently, used heterogenic Treg-specific Mettl14 knockout mice (Foxp3-Mettl14 f/+ cKO) reduce METTL14 expression...