A5068990717- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Atomic and Subatomic Physics Research
- Vagus Nerve Stimulation Research
- Neurological disorders and treatments
- Heart Rate Variability and Autonomic Control
- Optical Imaging and Spectroscopy Techniques
- Pain Management and Treatment
- Spinal Cord Injury Research
- Anesthesia and Sedative Agents
- Botulinum Toxin and Related Neurological Disorders
- Neural dynamics and brain function
- Stroke Rehabilitation and Recovery
- Epilepsy research and treatment
- Nerve injury and regeneration
- Cerebrospinal fluid and hydrocephalus
- Migraine and Headache Studies
- Cardiac Arrhythmias and Treatments
- Cognitive Functions and Memory
Beijing Tian Tan Hospital
2020-2025
Capital Medical University
2020-2025
National Clinical Research Center for Digestive Diseases
2022-2024
Capital University
2022-2024
Zhejiang University
2024
Southern Medical University
2022-2023
Zhujiang Hospital
2023
Chinese PLA General Hospital
2017-2021
The Military General Hospital of Beijing PLA
2010-2020
North China University of Science and Technology
2020
Severe traumatic brain injury (TBI) leads to acute coma and may result in prolonged disorder of consciousness (pDOC). We aimed determine whether right median nerve electrical stimulation is a safe effective treatment for accelerating emergence from after TBI.This randomised controlled trial was performed 22 centres China. Participants with at 7-14 days TBI were randomly assigned (1:1) either routine therapy (RMNS group) or (control group). The RMNS group received 20 mA, 300 μs, 40 Hz pulses,...
Accurately diagnosing patients with the vegetative state (VS) and minimally conscious (MCS) reached a misdiagnosis of approximately 40%.
Transcranial direct current stimulation (tDCS)1 has been reported to be a promising technique for consciousness improvement patients with disorders of (DOC).2 However, there no electrophysiological evidence demonstrate the efficacy tDCS on DOC. Therefore, we aim measure cortical excitability changes induced by in DOC, find supporting therapeutic In this study, enrolled sixteen including nine vegetative state (VS)3 and seven minimally conscious (MCS)4 (six females ten males). TMS-EEG was...
While repetitive transcranial magnetic stimulation (rTMS) has been applied in treatment of patients with disorders consciousness (DOC), a standardized protocol not proposed, and its therapeutic effects are inconsistently documented.To assess the efficacy rTMS improving persistent minimally conscious state (MCS) or unresponsive wakefulness syndrome (UWS), previously known as vegetative (VS).A prospective single-blinded study, selected subjects, was carried out. In total, 16 (5 MCS 11 VS/UWS)...
Disorders of consciousness are a heterogeneous mixture different diseases or injuries. Although some indicators and models have been proposed for prognostication, any single method when used alone carries high risk false prediction. This study aimed to develop multidomain prognostic model that combines resting state functional MRI with three clinical characteristics predict one year-outcomes at the single-subject level. The discriminated between patients who would later recover those not an...
Background: The modulation efficacy of Transcranial magnetic stimulation (TMS) on consciousness improvement patient with disorder (DOC) has not been definitely confirmed. Objective: This study proposes TMS-EEG to assess effects repetitive TMS (rTMS) brain DOC. Methods: Twenty sessions 10 Hz rTMS were applied over the dorsolateral prefrontal cortex for a Measures Coma Recovery Scale-Revised (CRS-R) score, TMS-evoked potential (TEP), perturbation complexity index (PCI), and global mean field...
Abstract NSI-566 is a stable, primary adherent neural stem cell line derived from single human fetal spinal cord and expanded epigenetically with no genetic modification. This being tested in clinical trials the U.S. for treatment of amyotrophic lateral sclerosis injury. In single-site, phase I study, we evaluated feasibility safety transplantation hemiparesis due to chronic motor stroke determined maximum tolerated dose future trials. Three cohorts (n = 3 per cohort) were transplanted...
Deep brain stimulation (DBS) has been preliminarily applied to treat patients with disorders of consciousness (DoCs). The study aimed determine whether DBS was effective for treating DoC and identify factors related patients' outcomes.Data from 365 DoCs who were consecutively admitted 15 July 2011 31 December 2021 retrospectively analysed. Multivariate regression subgroup analysis performed adjust potential confounders. primary outcome improvement in at 1 year.An overall year achieved 32.4%...
A transcranial direct current stimulation (tDCS) protocol (20 min, 2 mA, anodal electrode at the left dorsolateral prefrontal cortex and cathodal right supraorbital area) was applied in patients with different degrees of disorders consciousness (DoC). Although previous research indicates that it could improve patients' coma recovery scale-revised (CRS-R) scores, brain's electrophysiological responses to tDCS are still unclear. Therefore, present study performed explore underlying brain a...
The treatment of patients with disorders consciousness (DoC) remains a challenging issue, and spinal cord stimulation (SCS) has been reported to be promising for DoC in some studies.This study explores the efficiency SCS treating at different levels, including vegetative state/unresponsive wakefulness syndrome (VS/UWS) minimally conscious state (MCS) summarizes analyzes long-term effect related factors DoC.An overall positive outcome was reached 35 110 (31.8%). Among outcomes, MCS group...
Repetitive transcranial magnetic stimulation (rTMS) emerges as a promising non-invasive neuromodulation technique for the treatment of patients with disorders consciousness (DOC). The selection rTMS parameters significantly influences clinical therapeutic effects. However, differences in spatiotemporal responsiveness brain under different frequencies remain unclear. In this pilot study, functional near-infrared spectroscopy (fNIRS) was used to evaluate hemodynamic responses elicited by at...
Background Efficient bedside neurofunctional monitoring is crucial for managing disorders of consciousness (DoC). Ultrafast Power Doppler Imaging (uPDI) outperforms traditional Ultrasound in assessing the microcirculatory system. However, intracranial blood flow imaging traditionally faces limitations due to skull’s impedance. This constraint circumvented common post-craniectomy DoC patients, who present a unique observational window uPDI. Methods We conducted uPDI scans on five patients...
Spontaneous transient states were recently identified by functional magnetic resonance imaging and magnetoencephalography in healthy subjects. They organize coordinate neural activity brain networks. How spontaneous are altered abnormal conditions is unknown. Here, we conducted a state analysis on resting-state electroencephalography (EEG) source space developed transfer to patients with disorders of consciousness (DOC). uncovered different coordination patterns, including spatial power...
Objective: Diagnosis and prognosis of patients with disorders consciousness (DOC) is a challenge for neuroscience clinical practice. Transcranial magnetic stimulation combined electroencephalography (TMS-EEG) an effective tool to measure the level consciousness. However, scientific accurate method quantify TMS-evoked activity still lacking. This study applied fast perturbational complexity index (PCIst) diagnosis DOC patients. Methods: TMS-EEG data 30 normal healthy participants (NOR) 181...
The resting-state brain is composed of several discrete networks, which remain stable for 10-100 ms. These functional microstates are considered the building blocks spontaneous consciousness. Electroencephalography (EEG) microstate analysis may provide insight into altered dynamics underlying consciousness recovery in patients with disorders (DOC). We aimed to analyze EEG source space DOC, relationship between state-specific features and levels, corresponding patterns networks.We obtained...
Electroencephalography (EEG) and neuroimaging measurements have been highly encouraged to be applied in clinics of disorders consciousness (DOC) improve detection. We tested the relationships between neural complexity measured on EEG residual levels DOC patients.Resting-state was recorded from twenty-five patients with DOC. Lempel-Ziv (LZC) permutation (PLZC) were EEG, their analyzed patients.PLZC LZC values significantly distinguished a minimally conscious state (MCS), vegetative...
Repetitive transcranial magnetic stimulation (rTMS) has been applied for the treatment of patients with disorders consciousness (DOC). Timely and accurate assessments its modulation effects are very useful. This study evaluated rTMS on electroencephalography (EEG) oscillation in chronic DOC. Eighteen a diagnosis DOC lasting more than 3 months were recruited. All received one session 10-Hz at left dorsolateral prefrontal cortex then 12 them consecutive everyday 20 days. Resting-state EEGs...
Spinal cord stimulation (SCS) is a promising treatment for disorders of consciousness (DOC), but the underlying mechanism and most effective procedures remain uncertain. To optimize protocol, previous studies evaluated frequency-specific effects SCS on neurophysiological activities. However, whether how inter-stimulus interval (ISI) parameter affects neuromodulation in DOC remains unknown. We enrolled nine patients who had implanted devices conducted three different durations ISIs. Using...