A5100687201- Glioma Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Meningioma and schwannoma management
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve injury and regeneration
- Thermal Regulation in Medicine
- Ear and Head Tumors
- Metabolism and Genetic Disorders
- Congenital Anomalies and Fetal Surgery
- Parasitic infections in humans and animals
- Medicinal Plant Pharmacodynamics Research
- Neuroscience and Neuropharmacology Research
- Brain Metastases and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Pharmacological Effects and Toxicity Studies
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Facial Nerve Paralysis Treatment and Research
- Heme Oxygenase-1 and Carbon Monoxide
- Machine Learning in Healthcare
- Foreign Language Teaching Methods
- Boron Compounds in Chemistry
- Medical Malpractice and Liability Issues
University of Electronic Science and Technology of China
2022-2023
Tibet Autonomous Region People's Hospital
2023
Bayi Children's Hospital
2018-2022
Chinese PLA General Hospital
2019-2020
Chinese People's Liberation Army
2019
Southern Medical University
2007-2018
The Military General Hospital of Beijing PLA
2016-2017
Zhujiang Hospital
2002-2009
Haikou City People's Hospital
2008
Abstract NSI-566 is a stable, primary adherent neural stem cell line derived from single human fetal spinal cord and expanded epigenetically with no genetic modification. This being tested in clinical trials the U.S. for treatment of amyotrophic lateral sclerosis injury. In single-site, phase I study, we evaluated feasibility safety transplantation hemiparesis due to chronic motor stroke determined maximum tolerated dose future trials. Three cohorts (n = 3 per cohort) were transplanted...
Paeoniflorin (PF) is a polyphenolic compound derived from Radix Paeoniae Alba thathas anti-cancer activities in variety of human malignancies including glioblastoma. However, the underlying mechanisms have not been fully elucidated. Epithelial to mesenchymal transition (EMT), characterized as losing cell polarity, plays an essential role tumor invasion and metastasis. TGFβ, key member transforming growth factors, has demonstrated contribute glioblastoma aggressiveness through inducing EMT....
Paeoniflorin (PF), as one of the important valid natural compounds total glucosides peony, has displayed a potential effect in cancer prevention and treatment. Aggressive migration invasion, an process, can contribute to tumor progression through infiltrating surround normal tissue. Actin cytoskeleton rearrangement plays key role cells involving multiple signal pathways. HGF/c-Met signal, couple oncoprotein, been demonstrated regulate actin rearrangement. In our study, we aim explore whether...
Neural stem/progenitor cells (NS/PCs) play a therapeutic role in nervous system diseases and contribute to functional recovery. However, their efficacy is limited as the majority of die post-transplantation. In this study, collagen sponges were utilized carriers for NS/PCs. Basic fibroblast growth factor (bFGF), mitogen NS/PCs, was incorporated into stimulate NS/PC proliferation. effect native bFGF because it diffuses culture medium lost following exchange. To overcome problem,...
Lamotrigine (LTG), a broad-spectrum anti-epileptic drug widely used in treatment for seizures, shows potential efficacy Alzheimer's disease (AD) therapy. Chronic LTG rescues the suppressed long-term potentiation, loss of spines and cognitive deficits AβPP/PS1 mice, known to overexpr ess chimeric mouse/human mutant amyloid-β protein precursor (AβPP) human presenilin 1 (PS1). These changes are accompanied by reduction (Aβ) plaques density levels β-C-terminal fragment AβPP (β-CTF), cleaved...
Paeoniflorin, a polyphenolic compound derived from Radix Paeoniae Alba (Paeonia lactiflora), has exhibited anticancer activity in various human cancers, including glioblastoma. However, the mechanisms underlying effects of this have not been fully elucidated. Toll-like receptor 4 (TLR4) plays an important role regulation cancer cell proliferation and progression, high TLR4 expression glioblastoma specimens is associated with poor prognosis. The present study aimed to investigate whether...
Epithelial-to-mesenchymal transition (EMT) and angiogenesis have emerged as two pivotal events in cancer progression. Paeoniflorin has been widely studied experimental models clinical trials for treatment because of its anti-cancer property. However, the underlying mechanisms paeoniflorin EMT glioblastoma was not fully elucidated. The present study aimed to investigate whether inhibits angiogenesis, which involving c-Met suppression, while exploring potential ways degradation. In our study,...
To investigate the surgical treatment strategy of intracranial alveolar echinococcosis (AE) and clinical outcomes.
To confirm whether machine learning algorithms (MLA) can achieve an effective risk stratification of dying within 7 days after basal ganglia hemorrhage (BGH). We collected patients with BGH admitted to Sichuan Provincial People's Hospital between August 2005 and 2021. developed standard ML-supervised models fusion assess the prognostic compared them classical logistic regression model. also use SHAP algorithm provide clinical interpretability. 1383 were included divided into conservative...
Sub-hypothermia therapy is one of the treatments for patients with severe head injury. The objective to treat traumatic brain injury (TBI) by alleviating edema, protecting blood barrier (BBB), and preventing subsequent damage neurons. It can protect function depressing metabolism, reducing release excitatory amino acids free radicals, level lactic acid, lowering cytoskeletal structure.1 However, sub-hypothemia may affect patients’ coagulatory including amendment hypercoagulation state or...
Objective To investigate the clinical application value and changing regularity of several metrics diffusion tensor imaging (DTI) in consciousness disorder patients(DOC). Methods The patient who were diagnosed with DOC(VS group was 66, MCS 9) recruited at The Bayi Brain Hospital affiliated to Beijing PLA from Jun. 2014 Dec. 2015 examined DTI. evaluating data brainstem, subcortical thalamus related regions interesting (ROI) collected respectively. ROI between two groups compared, then...
Objective To discuss the surgical skills in microsurgical resection of large acoustic neurornas via retrosigmoid approach for reducing neural damage and complications such surgeries. Methods Twenty-one cases neuroma treated with microsurgery were retrospectively analyzed view approach, techniques, intraoperative accidents, management postoperative complications. Results The tumors totally removed 18 subtotally 3 cases. facial nerve function was well preserved 17 (80.9%), 5 (23.8%)....