A5074410764- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Alzheimer's disease research and treatments
- Flavonoids in Medical Research
- Cancer-related molecular mechanisms research
- Intracerebral and Subarachnoid Hemorrhage Research
- Immune cells in cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
- Gut microbiota and health
- Genetic Neurodegenerative Diseases
- Tryptophan and brain disorders
- Phytochemical Studies and Bioactivities
- Advanced biosensing and bioanalysis techniques
- Saffron Plant Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Molecular Sensors and Ion Detection
- Case Reports on Hematomas
- Spinal Cord Injury Research
- Neurological diseases and metabolism
- Ion channel regulation and function
- Sphingolipid Metabolism and Signaling
- Curcumin's Biomedical Applications
University of Electronic Science and Technology of China
2021-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2025
Southwest Medical University
2018-2023
Trillium tschonoskii Maxim (TTM), a traditional Chinese medicine, has been demonstrated to have potent anti-tumor effect. Recently, polyphyllin VI (PPVI), main saponin isolated from TTM, was reported by us significantly suppress the proliferation of non-small cell lung cancer (NSCLC) via induction apoptosis and autophagy in vitro vivo. In this study, we further found that NLRP3 inflammasome activated PPVI administrated A549-bearing athymic nude mice. As is known us, pyroptosis an...
Emerging evidence indicates that the enhancement of microglial autophagy inhibits NLRP3 inflammasome mediated neuroinflammation in Alzheimer's disease (AD). Meanwhile, low density lipoprotein receptor-related protein 1 (LRP1) highly expressed microglia is able to negatively regulate and positively autophagy. In addition, we have previously reported an active lychee seed fraction enriching polyphenol (LSP) exhibits anti-neuroinflammation Aβ-induced BV-2 cells. However, its molecular mechanism...
Blood–brain barrier (BBB) dysfunction has been implicated in Alzheimer's disease (AD) and is closely linked to the release of proinflammatory cytokines brain capillary endothelial cells. We have previously reported that lychee seed polyphenols (LSP) exerted anti‐neuroinflammatory effect. In this study, we aimed explore protective effect LSP on BBB integrity. The monolayer permeability bEnd.3 cells, mRNA level protein expression tight junction proteins (TJs), including Claudin 5, Occludin,...
Discovery of drugs rapidly and effectively is an important aspect for Alzheimer's disease (AD). In this study, a novel high-throughput screening (HTS) method aims at the small-molecules with amyloid-β (Aβ) binding affinity from natural medicines, based on combinational use biolayer interferometry (BLI) ultra-high-performance liquid chromatography coupled diode-array detector quadrupole/time-of-flight tandem mass spectrometry (UHPLC-DAD-Q/TOF-MS/MS) has been firstly developed. Briefly,...
Abstract Background NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer’s disease (AD). Microglial autophagic degradation not only decreases deposits extracellular Aβ fibrils but also inhibits activation NRLP3 inflammasome. Here, we aimed to identify potent autophagy enhancers from Penthorum chinense Pursh (PCP) that alleviate pathology AD via inhibiting Methods At first, activity-guided isolation was performed PCP. Secondly,...
Parkinson's disease (PD) is the second most common neurodegenerative disease. Chlorogenic acid (CGA) a polyphenolic substance derived from various medicinal plants. Although CGA reported to have potential anti-PD effect, beneficial effect and underlying mechanism remain unclear. In this study, we aimed further investigate protective clarify of action in Caenorhabditis elegans (C. elegans) models PD.Measurements a-synuclein aggregation, movement disorders, lipid, ROS malondialdehyde (MDA)...
Closed head injury (CHI) provokes a prominent neuroinflammation that may lead to long-term health consequences. Microglia plays pivotal and complex roles in neuroinflammation-mediated neuronal insult repair following CHI. We previously reported induced neural stem cells (iNSCs) can block the effects of CXCL12/CXCR4 signaling on NF-κB activation activated microglia by CXCR4 overexpression. Here we aim uncover mechanism upregulation iNSCs. performed bioinformatic analysis detect differentially...
Motor function recovery after complete spinal cord injury remained as a challenge in medical field, while one of the key approaches is promoting local microenvironments. In this research, we performed conjugated therapy by transplantation neural stem cell (NSC) scaffolds and umbilical mesenchymal derived exosomes (ucMSC-exos) for treatment transactional (SCI). We first demonstrated anti-inflammatory effects ucMSC-exos vitro found that could regulate microglia polarization from M1 to M2, an...
Amyloid-β (Aβ) is commonly recognized as the most important factor that results in neuronal cell death and accelerates progression of Alzheimer's disease (AD). Increasing evidence suggests microglia activated by Aβ release an amount neurotoxic inflammatory cytokines contribute to neuron aggravate AD pathology. In our previous studies, we found lychee seed fraction (LSF), active derived from seed, could significantly improve cognitive function rats inhibit Aβ-induced neuroinflammation vitro,...
Alzheimer's disease is a neurodegenerative caused by excessive amyloid β protein-induced neurotoxicity. However, drugs targeting protein production face many problems, such as the low utilization rate of cells and difficulty in penetrating blood-brain barrier. A tetrahedral framework nucleic acid new type nanonucleic structure that functions therapy drug carrier. Here, we synthesized BACE1 aptamer-modified tested its therapeutic effect on vitro vivo. Our results demonstrated could be used...
The pathogenesis of Huntington's disease (HD), an inherited progressive neurodegenerative disease, is highly associated with the cytotoxicity-inducing mutant huntingtin (mHtt) protein. Emerging evidence indicates that autophagy plays a pivotal role in degrading aggregated proteins such as mHtt to enhance neuronal viability. In this study, by employing preparative high-performance liquid chromatography (pre-HPLC), ultra-high performance diode-array-detector quadrupole time-of-flight mass...
Anoectochilus roxburghii (Wall.) Lindl. polysaccharides (ARPs) have been reported to exhibit multiple pharmacological activities including anti-inflammatory and anti-hyperglycemia. This study aims investigate the effect of ARPs on cognitive dysfunction induced by high fat diet (HFD).Six-week-old male mice were treated with dietary supplementation for 14 weeks. The function was determined assessing changes in spatial learning memory ability, neurotrophic factors hippocampus, inflammatory...
Resistance to traditional antiepileptic drugs is a major challenge in chronic epilepsy treatment. MicroRNA-based gene therapy promising alternative but has demonstrated limited efficacy due poor blood-brain barrier permeability, cellular uptake, and targeting efficiency. Adenosine an endogenous antiseizure agent deficient the epileptic brain elevated adenosine kinase (ADK) activity reactive A1 astrocytes. We designed nucleic acid nanoantiepileptic drug (tFNA-ADKASO@AS1) based on tetrahedral...
Abstract Toll-like receptor (TLR) 4 contributes to be the induction of neuroinflammation by recognizing pathology-associated ligands and activating microglia. In addition, numerous physiological signaling factors act as agonists or antagonists TLR4 expressed non-immune cells. Recently, was found highly in cerebellar Purkinje neurons (PNs) involved maintenance motor coordination through pathways, but precise mechanisms remain unclear. Here we report that mice with PN specific deletion (TLR4...
To confirm whether machine learning algorithms (MLA) can achieve an effective risk stratification of dying within 7 days after basal ganglia hemorrhage (BGH). We collected patients with BGH admitted to Sichuan Provincial People's Hospital between August 2005 and 2021. developed standard ML-supervised models fusion assess the prognostic compared them classical logistic regression model. also use SHAP algorithm provide clinical interpretability. 1383 were included divided into conservative...
Abstract Background Abnormally elevated xanthine oxidase (XO) activity has been verified to cause various pathological processes, such as gout, oxidative stress injury and metabolic syndrome. Thus, XO activators may exhibit above potential toxicological properties. Plumbagin (PLB) is an important active compound in traditional Chinese medicine (TCM), while its obvious toxic effects have reported, including diarrhea, skin rashes hepatic toxicity. However, the toxicity associated with...
Emerging evidence indicates that blood–retinal barrier (BRB) damage is the main cause of diabetic retinopathy (DR), and downregulation tight proteins (TJs) located between endothelial cells activation NLRP3 inflammasome-mediated inflammation in Müller result BRB injury. In this study, we aimed to study protective effect lychee seed polyphenol (LSP) on integrity mechanism action. By establishing a cellular model injury by using high glucose (HG)-induced hRECs or co-culture system with MIO-M1...