A5102916224- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects of Natural Compounds
- Molecular Sensors and Ion Detection
- Liver Disease Diagnosis and Treatment
- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Drug-Induced Hepatotoxicity and Protection
- Andrographolide Research and Applications
- Advanced Chemical Sensor Technologies
- Plant Virus Research Studies
- Herpesvirus Infections and Treatments
- Liver Disease and Transplantation
- Gout, Hyperuricemia, Uric Acid
- Drug Transport and Resistance Mechanisms
- Poxvirus research and outbreaks
- PI3K/AKT/mTOR signaling in cancer
- Phytochemistry and Biological Activities
- Nanoplatforms for cancer theranostics
- Traditional Chinese Medicine Analysis
- Smart Agriculture and AI
Southwest Medical University
2019-2025
Affiliated Hospital of Southwest Medical University
2019-2025
First Affiliated Hospital of Sichuan Medical University
2019-2024
Shandong Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Zhejiang University
2019-2020
Dalian Institute of Chemical Physics
2010-2016
Chinese Academy of Sciences
2010-2016
Dalian Medical University
2014-2016
Second Affiliated Hospital of Dalian Medical University
2015-2016
Sepsis-Associated Liver Injury (SALI) is an independent risk factor for death from sepsis. The aim of this study was to develop interpretable machine learning model early prediction 28-day mortality in patients with SALI. Data the Medical Information Mart Intensive Care (MIMIC-IV, v2.2, MIMIC-III, v1.4) were used study. cohort MIMIC-IV randomized training set (0.7) and internal validation (0.3), MIMIC-III (2001 2008) as external validation. features more than 20% missing values deleted...
Daphnetin has been developed as an oral medicine for treatment of coagulation disorders and rheumatoid arthritis in China, but its vitro metabolism remains unknown. In the present study, UDP-glucuronosyltransferase (UGT) conjugation pathways daphnetin were characterized. Two metabolites, 7-<i>O</i>-monoglucuronide (M-1) 8-<i>O</i>-monoglucuronide (M-2), identified by liquid chromatography/mass spectrometry NMR when was incubated, respectively, with liver microsomes from human (HLM), rat...
Cinobufagin (CB), a major bioactive component of the traditional Chinese medicine Chansu, has been reported to have potent antitumor activity. In this study, in vitro metabolism CB among species was compared with respect metabolic profiles, enzymes involved, and catalytic efficiency by using liver microsomes from human (HLM), mouse (MLM), rat (RLM), dog (DLM), minipig (PLM), monkey (CyLM). Significant differences were revealed. particular, species-specific deacetylation epimerization...
Sanguinarine (SAG) is the most abundant constituent of Macleaya cordata (Willd.) R. Br. (Popaceae). SAG has shown antimammary and colorectal metastatic effects in mice vivo, suggesting its potential for cancer chemotherapy.To determine antimetastatic effect underlying molecular mechanisms on melanoma.CCK8 assay was used to inhibition proliferation A375 A2058 cells. Network pharmacology analysis applied construct a compound-target network select therapeutic targets against melanoma. Molecular...
Colorectal cancer (CRC) resistance to 5-fluorouracil (5-FU), primarily driven by stem cells (CSCs) and epithelial-mesenchymal transition (EMT), remains a major clinical challenge, necessitating novel therapeutic strategies. This study aims evaluate the potential of pentagalloyl glucose (PGG), bioactive compound derived from Bouea macrophylla seeds, in overcoming 5-FU CRC. Anti-tumor effects PGG were investigated using two- three-dimensional (2D 3D) cell culture models subcutaneous xenograft...
Type 2 diabetes mellitus (T2DM) and cancers are two globally prevalent diseases which can increase the incidence of each other. Intestinal α-glucosidase β-glucuronidase key targets for glycaemic control chemotherapy detoxification, respectively. This study first found that leaf methanol extract Millettia pachycarpa displayed dual inhibition to enzymes. The dually active constituents were then isolated identified as prenylated isoflavones 6,8-diprenylorobol 6,8-diprenylgenistein....
UDP‐glucuronosyltransferases (UGTs), the most important phase II drug metabolizing enzymes (DMEs), could metabolize many drugs and various endogenous substances including bilirubin, steroid hormones, thyroid bile acids fat‐soluble vitamins. Evaluation of inhibitory effects compounds on UGTs is clinically because inhibition UGT isoforms not only result in serious drug–drug interactions (DDIs), but also induce metabolic disorders substances. The aim present study was to investigate carvacrol...
Since smallpox was eradicated in 1980, the monkeypox virus (MPXV) has emerged as most threatening orthopoxvirus world. In this study, we conducted a comprehensive analysis of currently published complete genome sequences virus. The core/variable regions were identified through core-pan MPXV. Besides single-nucleotide polymorphisms, our study also revealed that specific genes, multi-copy repeat sequences, and recombination fragments are primarily distributed variable region. This result...
This Research proposes an intelligent pruning method based on the improved Mask R-CNN (Mask Region-based Convolutional Neural Network) model to address shortcomings of technology for Sichuan pepper trees. Utilizing ResNeXt-50 as backbone network, algorithm optimizes anchor boxes in RPN (Region Proposal layer adapt complex morphology tree branches, thereby enhancing target detection and segmentation performance. Further reducing quantization error RoI Interest) Align through bilinear...
Abstract Glucuronidation mediated by uridine 5′-diphospho (UDP)-glucuronosyltransferase is an important detoxification pathway. However, identifying a selective probe of UDP- glucuronosyltransferase complicated because the significant overlapping substrate specificity displayed enzyme. In this paper, desacetylcinobufagin (DACB) 3- O - and 16- -glucuronidation were found to be isoform-specific reactions for UGT1A4 UGT1A3, respectively. DACB was well characterized as simultaneously determining...
The members of the Poxviridae family are globally distributed all over world and can cause infectious diseases. Although genome sequences publicly available for representative isolates genera, studies on criteria genome-based classification within have rarely been reported. In our study, 60 genomes were re-annotated using Prokka. By BLAST filtration MCScanX, synteny similarity whole genomic amino acid visualized. According to analysis pattern, Chordopoxvirinae Entomopoxvirinae subfamilies be...