A5100380511- Limits and Structures in Graph Theory
- Ferroptosis and cancer prognosis
- Advanced Graph Theory Research
- Graph theory and applications
- RNA Interference and Gene Delivery
- Stock Market Forecasting Methods
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Advanced Topology and Set Theory
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Plant Stress Responses and Tolerance
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioactive natural compounds
- Plant Molecular Biology Research
- Ginseng Biological Effects and Applications
- Immunotherapy and Immune Responses
- Protist diversity and phylogeny
- Zebrafish Biomedical Research Applications
- Machine Learning in Bioinformatics
- Big Data and Business Intelligence
- Single-cell and spatial transcriptomics
- Gene expression and cancer classification
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
Harbin Medical University
2024-2025
Chengdu University of Traditional Chinese Medicine
2025
Fourth Affiliated Hospital of Harbin Medical University
2025
Duke University
2024
Children's Hospital of Capital Institute of Pediatrics
2024
Shanghai University of Traditional Chinese Medicine
2022-2024
Qilu University of Technology
2022-2024
First Affiliated Hospital of Harbin Medical University
2024
Shandong Academy of Sciences
2022-2024
Second Affiliated Hospital of Harbin Medical University
2024
Abstract Arterial occlusion-induced ischemic stroke (IS) is a highly frequent subtype. Nuclear factor erythroid 2-related 2 (NRF2) transcription that modulates antioxidant genes. Its role in IS still unelucidated. The current study focused on constructing transient middle cerebral artery occlusion (tMCAO) model for investigating the NRF2-related mechanism underlying ischemia/reperfusion (I/R) injury. Each male C57BL/6 mouse was injected with/with no specific NRF2 activator post-tMCAO....
Time series forecasting has played the key role in different industrial, including finance, traffic, energy, and healthcare domains. While existing literatures have designed many sophisticated architectures based on RNNs, GNNs, or Transformers, another kind of approaches multi-layer perceptrons (MLPs) are proposed with simple structure, low complexity, {superior performance}. However, most MLP-based methods suffer from point-wise mappings information bottleneck, which largely hinders...
Free radicals can pose health risks and reduce food quality when accumulated excessively. Fish byproducts, often underutilized, offer a valuable opportunity for extracting bioactive peptides with antioxidant activities. This study aimed to optimize the conditions from sturgeon bone using response surface methodology. The findings revealed that trypsin was most effective protease hydrolyzing vertebra. optimization were determined as follows: solid-liquid ratio of 1:21.90, enzyme concentration...
Psoriasis is a chronic inflammatory skin disease, which holds high incidence in China. However, professional dermatologists who can diagnose psoriasis early and correctly are insufficient China, especially the rural areas. A smart approach to identify by pictures would be highly adaptable countrywide could play useful role diagnosis regular treatment of psoriasis.Design evaluation identification system based on clinical images (without relying dermatoscope) that works effectively similar...
Autophagy is an efficient and attractive protein degradation pathway in addition to the ubiquitin-proteasome system. Herein, systematic optimization of coumarin analogs linked with CDK9 inhibitor SNS-032 reported that may bind cyclin-dependent kinase 9 (CDK9) microtubule-associated 1 light chain 3 beta (LC3B) simultaneously, which leads selective autophagic targeted CDK9/cyclin T1 different from PROTAC degrader THAL-SNS-032. Further mechanism studies revealed autophagy-lysosome pathway,...
Networks are prevalent and have posed many fascinating research questions. How can we spot similar users, e.g., virtual identical twins, in Cleveland for a New Yorker? Given query disease, how prioritize its candidate genes by incorporating the tissue-specific protein interaction networks of those diseases? In most, if not all, existing network ranking methods, nodes objects with finest granularity. this paper, propose new data model, Network (NoN), where each node main itself be further...
Accumulating evidence indicated that oxidative stress is closely related to inflammation and the progression of multiple chronic diseases, which seriously threaten host health. Currently, plant-derived polysaccharides have been demonstrated ameliorate negative effects on host, but potential protective effect radix paeoniae alba polysaccharide (RPAP) not well characterized. Here, we investigated whether different doses RPAP administration could alleviate lipopolysaccharide (LPS)-induced...
Ischemic stroke (IS) represents a harmful neurological disorder with limited treatment options. Ferroptosis accounts for the iron-dependent, nonapoptotic cell death pattern, which shows feature of fatal lipid ROS accumulation. Nonetheless, ferroptosis-related biomarkers identifying IS early are currently lacking. The present study focused on investigating possible and analyzing their effects immune infiltration. Altogether five hub differentially expressed genes (DEFRGs) were identified from...
This study investigated how belief in a just world (BJW) influences prosocial behavior tendency (PBT) through psychological resilience (PR), and examined empathic capacity (EC) moderates this mediation process. Data were collected from 955 Chinese university students (Mage = 19.5 years, SD 1.3; 65.6% female) using validated scales measuring BJW, PBT, PR, EC. Three key findings emerged: (1) BJW positively predicted PBT both directly (β 0.301, p < 0.001) indirectly PR; (2) EC moderated the...
DNASE1L3, an enzyme highly expressed in DCs, is functionally important for regulating autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3 leads development diseases both humans mice. However, despite the well-established causal relationship between immunity, little known about involvement regulation antitumor foundation modern immunotherapy. In this study, we identify as a potentially new regulator immunity tumor suppressor colon cancer. humans, downregulated...
HLA‐A*24:617 differs from HLA‐A*24:02:01:01 by one nucleotide in exon 4.
Huangqi Guizhi Wuwu decoction (HQGZWWD) has been used to treat and prevent deep vein thrombosis (DVT) in China. However, its potential mechanisms of action remain unclear. This study aimed utilize network pharmacology molecular docking technology elucidate the HQGZWWD DVT.We identified main chemical components by reviewing literature using a Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. We GeneCards Online Mendelian Inheritance Man databases identify targets DVT....
Resistance to traditional antiepileptic drugs is a major challenge in chronic epilepsy treatment. MicroRNA-based gene therapy promising alternative but has demonstrated limited efficacy due poor blood-brain barrier permeability, cellular uptake, and targeting efficiency. Adenosine an endogenous antiseizure agent deficient the epileptic brain elevated adenosine kinase (ADK) activity reactive A1 astrocytes. We designed nucleic acid nanoantiepileptic drug (tFNA-ADKASO@AS1) based on tetrahedral...
Ant Financial has over 100 million subscribers, resulting in a significant amount of daily money influx and outflow. Therefore, capital management will be under lot stress. As result, it's critical to precisely estimate inflows outflows funds while maintaining low level liquidity risk keeping up with everyday business operations. Knowing when make an accurate prediction is often the most important stage forecasting. Instead, than duplicating what already happened not happen again future,...
Abstract: Panax notoginseng has the effect of stimulating circulation to end stasis. Our study was designed evaluate anti-thrombotic protoparaxotriol saponins (PTS) from P. and involved mechanisms. A thrombosis model constructed, activity PTS determined by erythrocyte staining, heart rate, blood flow velocity. In addition, quantitative real-time polymerase chain reaction used identify changes in expression genes related coagulation, inflammation, apoptosis. alleviated arachidonic...
A vast ocean of data is collected every day, and numerous applications call for the extraction actionable insights from data. One important task to detect untrustworthy information because such usually indicates critical, unusual, or suspicious activities. In this paper, we study problem detecting a novel perspective correlating comparing multiple sources that describe same set items. Different existing work, recognize importance time dimension in modeling commonalities among sources. We...
The rapid growth of medical recording data has increased the demand for automated analysis. An important problem in recent research is diagnosis, which to infer likely diseases observed symptoms. Existing approaches typically perform inference on a sparse bipartite graph with two sets nodes representing and symptoms, respectively. By using this graph, existing methods basically assume no direct dependency exists between (or symptoms), may not be true practice. To address limitation, we...