A5055185034- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Sphingolipid Metabolism and Signaling
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Peripheral Neuropathies and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related molecular mechanisms research
- Myasthenia Gravis and Thymoma
- Hereditary Neurological Disorders
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Acute Ischemic Stroke Management
- Neonatal and fetal brain pathology
- Nitric Oxide and Endothelin Effects
- Protein Tyrosine Phosphatases
- Thermal Regulation in Medicine
- RNA modifications and cancer
- Barrier Structure and Function Studies
- Alzheimer's disease research and treatments
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Redox biology and oxidative stress
- RNA regulation and disease
Henan University Huaihe Hospital and Huaihe Clinical Institute
2025
Harbin Medical University
2021-2024
First Affiliated Hospital of Harbin Medical University
2021-2024
Abstract Arterial occlusion-induced ischemic stroke (IS) is a highly frequent subtype. Nuclear factor erythroid 2-related 2 (NRF2) transcription that modulates antioxidant genes. Its role in IS still unelucidated. The current study focused on constructing transient middle cerebral artery occlusion (tMCAO) model for investigating the NRF2-related mechanism underlying ischemia/reperfusion (I/R) injury. Each male C57BL/6 mouse was injected with/with no specific NRF2 activator post-tMCAO....
Immune infiltration plays an important role in the course of ischemic stroke (IS) progression. Cuproptosis is a newly discovered form programmed cell death. To date, no studies on mechanisms by which cuproptosis-related genes regulate immune IS have been reported.IS-related microarray datasets were retrieved from Gene Expression Omnibus (GEO) database and standardized. was extracted quantified based processed gene expression matrix. The differences between group normal as well correlation...
Ischemic stroke (IS) represents a harmful neurological disorder with limited treatment options. Ferroptosis accounts for the iron-dependent, nonapoptotic cell death pattern, which shows feature of fatal lipid ROS accumulation. Nonetheless, ferroptosis-related biomarkers identifying IS early are currently lacking. The present study focused on investigating possible and analyzing their effects immune infiltration. Altogether five hub differentially expressed genes (DEFRGs) were identified from...
Background Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) mediated by autoimmunity. No objective clinical indicators are available for diagnosis and prognosis MS. Extracellular proteins most glycosylated likely to enter into body fluid serve as potential biomarkers. Our work will contribute in-depth study functions extracellular discovery Methods MS expression profiling data human brain was downloaded from Gene Expression Omnibus (GEO)....
Background: Ischemic stroke is the most common incident. Sphingosine-1-phosphate (S1P) receptor 3 (S1PR3) a member of downstream G protein-coupled family S1P. The effect S1PR3 on ischemic remains elusive. Methods: We downloaded two middle cerebral artery occlusion (MCAO) microarray datasets from Gene Expression Omnibus (GEO) database and screened differentially expressed genes (DEGs). Then, we performed weighted gene coexpression network analysis (WGCNA) identified core module related to...
Ischemic stroke (IS) is a common disease endangering human life and health. Cerebral ischemia triggers series of complex harmful events, including excitotoxicity, inflammation cell death, as well increased nitric oxide production through the activation synthase (NOS). Oxidative stress plays major role in cerebral reperfusion. Sphingosine 1-phosphate receptor subtype 3 (S1PR3), member S1P's G protein-coupled receptors S1PR1-S1PR5, involved variety biological effects body, its regulating...
Abstract Guillain–Barré syndrome (GBS) is an autoimmune disorder wherein the composition and gene expression patterns of peripheral blood immune cells change significantly. It triggered by antigens with similar epitopes to Schwann that stimulate a maladaptive response against nerves. However, atlas for in patients GBS has not yet been constructed. This monocentric, prospective study. We collected 5 acute inflammatory demyelinating polyneuropathy (AIDP) 3 healthy controls hospitalized First...
A 46-year-old man had recurrent episodes of diffuse hyperhidrosis and hypothermia (Video 1) lasting approximately 20 minutes for days. His temperature was 35.4°C, blood pressure 159/101 mm Hg, heart rate 120/min, the only neurologic sign during an episode. Seizures were considered, but EEG episode normal. MRI showed corpus callosum agenesis (Figure). He diagnosed with Shapiro syndrome, which may be due to hypothalamic dysfunction is responsive clonidine carbamazepine.1,2 Because lack...
Abstract In the current study, we aimed to investigate whether disulfiram (DSF) plays a neuroprotective role in cerebral ischemia-reperfusion (CI-RI) injury by regulating ferredoxin 1 (FDX1) modulating copper ion (Cu) levels and inhibiting inflammatory response. To simulate CI-RI, transient middle artery occlusion (tMCAO) model C57/BL6 mice was employed. Mice were administered with or without DSF before after tMCAO. Changes infarct volume tMCAO observed using TTC staining. Nissl staining...
Abstract Guillain-Barré syndrome (GBS) is an autoimmune disorder wherein the composition and gene expression patterns of peripheral blood immune cells change significantly. It triggered by antigens with similar epitopes to Schwann that stimulate a maladaptive response against nerves. However, atlas for in patients GBS has not yet been constructed. Herein, we performed single-cell RNA sequencing mononuclear (PBMCs) from healthy donors acute inflammatory demyelinating polyneuropathy (AIDP) at...