A5100459373- Phytochemicals and Antioxidant Activities
- MicroRNA in disease regulation
- Fungal Biology and Applications
- Trace Elements in Health
- Natural product bioactivities and synthesis
- Microbial Metabolism and Applications
- Fermentation and Sensory Analysis
- RNA modifications and cancer
- Plant Pathogens and Fungal Diseases
- Sphingolipid Metabolism and Signaling
- Acute Myocardial Infarction Research
- Phytochemical compounds biological activities
- Pediatric health and respiratory diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Biological and pharmacological studies of plants
- Food Quality and Safety Studies
- Postharvest Quality and Shelf Life Management
- Polysaccharides and Plant Cell Walls
- Microbial Natural Products and Biosynthesis
- Bioactive Compounds in Plants
- Phytochemistry and Bioactive Compounds
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
Chengdu University of Traditional Chinese Medicine
2018-2024
Southwestern Institute of Physics
2023-2024
Tea Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Xuzhou Medical College
2024
First Affiliated Hospital of Harbin Medical University
2020-2023
Harbin Medical University
2015-2023
Longyan University
2023
Jiangxi University of Traditional Chinese Medicine
2021-2023
Qingdao University
2022
Flavonoids are a kind of essential substance for the human body because their antioxidant properties and extremely high medicinal value. Citrus reticulata "Dahongpao" (DHP) is special citrus variety that rich in flavonoids, however little known about its systematic flavonoids profile. In present study, presence five important varieties, including DHP, grandis Tomentosa (HZY), ichangensis Swingle (YCC), sinensis (L.) Osbeck (TC), 'Buzhihuo' (BZH), was determined using UPLC-ESI-MS/MS-based,...
Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC). In a rat model, chronic ZD induces an inflammatory gene signature that fuels ESCC development. microRNAs regulate expression and are aberrantly expressed in cancers. Here we investigated whether (23 weeks) also protumorigenic microRNA signature. Using nanoString technology, evaluated profiles esophagus six additional tissues (skin, lung, pancreas, liver, prostate peripheral blood mononuclear cells [PBMC])....
GuangChenpi (GCP), the dried pericarps of Citrus reticulata 'Chachi', has been consumed daily as a food and dietary supplement in China for centuries. Its health benefits are generally recognized to be dependent on storage time. However, specific roles microorganisms metabolites during long-term still unclear. In this study, comparative metabolomics high-throughput sequencing techniques were used investigate effects co-existing GCP stored from 1 30 years. total, 386 identified characterized....
In this study, comprehensive and systematic nontargeted metabolomics analysis was performed with the metabolites of Zangju peel (
Abstract BACKGROUND Sojae semen praeparatum (SSP) is an edible fermented product and traditional Chinese medicinal, with demonstrated bioactivity. Fermentation important factor that influences the bioactivity of SSP. However, changes in bioactive compounds SSP during fermentation process remain largely unknown. RESULTS The study revealed significantly enhanced SSP, particularly terms antioxidant capacity acetylcholinesterase (AChE) inhibition. Antioxidant assays increased prolonged time,...
Background: To reveal candidate genes and the molecular genetic mechanism underlying primary feather color trait in ducks, a genome-wide association study (GWAS) for was performed based on genotyping-by-sequencing (GBS) technology native Chinese female duck, Longyan Shan-ma ducks. Methods: Blood genomic DNA from 314 duck were genotyped using GBS technology. A GWAS with genome variations an univariate linear mixed model all SNPs autosomes. Results: Seven significant single nucleotide...
Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using rat model that recapitulates features human ESCC, mechanism whereby Zn regulates miR-31 expression to promote ESCC examined. To inhibit vivo overexpression Zn-deficient rats (n = 12–20 per group), locked nucleic acid–modified anti-miR-31 oligonucleotides were administered over five weeks. was determined by northern...
Background: Ischemic stroke is the most common incident. Sphingosine-1-phosphate (S1P) receptor 3 (S1PR3) a member of downstream G protein-coupled family S1P. The effect S1PR3 on ischemic remains elusive. Methods: We downloaded two middle cerebral artery occlusion (MCAO) microarray datasets from Gene Expression Omnibus (GEO) database and screened differentially expressed genes (DEGs). Then, we performed weighted gene coexpression network analysis (WGCNA) identified core module related to...
(PCR), the mature fruit peel of
Citrus cultivars are widely spread worldwide, and some of them only differ by specific mutations along the genome. It is difficult to distinguish traditional morphological identification. To accurately identify such similar cultivars, subtle differences between must be detected. In this study, UPLC-ESI-MS/MS-based targeted metabolomics analysis was conducted study chemical two closely related citrus reticulata ‘DHP’ C . ‘BZH’. Totally 352 metabolites including 11 terpenoids, 35 alkaloids, 80...
Alzheimer’s disease (AD) has become a worldwide affecting human health and resulting in heavy economic burden on the healthcare system. Polygonati rhizoma (PR), kind of traditional Chinese medicine (TCM), is known to improve learning memory abilities. However, its AD-treating material basis therapeutic potential for treatment AD have remained unclear. Therefore, present study aimed uncover key active ingredients PR AD. First, we used comparative metabolomics identify edible medicinal PR....
Significance Prostate cancer in man is associated with Zn loss, citrate metabolite reduction, overexpression of the miR-183-96-182 cluster, and regulation homeostasis through transporter suppression. Our mechanistic study shows that a low-Zn diet upregulates this miR cluster Zn-deficient middle-aged rat prostate, ZIP1 mRNA/protein downregulation citrate-oxidizing metabolic phenotype, linking reduction directly to prostatic loss. The findings show transcriptional signal pathways induced by...
There are thousands of traditional Chinese medicines in China, and they all have to be stored for a period time the reason market price or other factors. But some especially need longer, clinical efficacy will better. The cause mechanism this phenomenon attracted much attention recent years. In study, we analyze "the longer storage better" Pericarpium Citri Reticulatae (PCR); method microscopic molecular identification was used identify fungi separated purified from PCR. HPLC UV...
Blue indigo dye, an important natural colorant, is used for textiles and food additives worldwide, while another red isomer, indirubin, the major active ingredient of a traditional Chinese medicine named "Danggui Longhui Wan" treating various diseases including granulocytic leukemia, cancer, Alzheimer's disease. In this work, we constructed new highly efficient indigoid production system by optimizing novel terpenoid cyclase, XiaI, from xiamycin biosynthetic pathway. Through introducing...
Pericarpium Citri Reticulatae (PCR) is a natural citrus by-product with beneficial health and nutritive properties that used widely in food an ingredient traditional Chinese medicine. PCR improves gradually aging. However, the present research has not yet revealed reasons for this. Some data prove important role of microorganisms quality tobacco fermented tea time aging these foods. Our studies further proved coexisting Aspergillus niger plays change flavonoids volatile oil during this...
Introduction Dendrobium is an epiphytic herb plant with neuroprotective, gastroprotective, anti-inflammatory, and immunomodulatory effects. It often found attached to tree trunks or rocks. With the development of dendrobium industry, numerous patterns exist, such as crushed stone, stump, sawdust. The study metabolites endophytes D. nobile under different patterns, which revealed effects on from perspectives metabolomics microbiology, great significance for healthy . Methods In study, five...
Edible herbal medicines contain macro- and micronutrients active metabolites that can take part in biochemical processes to help achieve or maintain a state of well-being. Citri Reticulatae Pericarpium (CRP) is an edible medicinal herb used as component the traditional Chinese medicine (TCM) approach treating COVID-19 China. However, material basis related mechanistic research regarding this for treatment are still unclear. First, wide-targeted UPLC-ESI-MS/MS-based comparative metabolomics...
The pseudokinase Tribble 3 (TRIB3) is known as a regulator in cellular responses to variety of stresses, such glucose insufficiency and endoplasmic reticulum (ER) stress. TRIB3 upregulated various cancer tissues closely connected the poor prognosis patients. However, underlying regulation function glioblastoma (GBM) still largely unknown. In this study, upregulation was confirmed both primary specimens from GBM patients vitro with cell lines. Overexpression specific transcripts promoted...