Irinotecan (IRI) is considered an option for second-line treatment of advanced gastric cancer; however, acquired drug resistance currently limits its clinical application. Recently, many researchers have shown that autophagy plays a crucial role in the tumor cells to chemotherapy and radiotherapy. In this study, we investigated relationship between antitumor activity IRI cancer cells.We used MTT assay, flow cytometry immunofluorescence staining detect viability, apoptosis cancer. Western...

Citrus cultivars are widely spread worldwide, and some of them only differ by specific mutations along the genome. It is difficult to distinguish traditional morphological identification. To accurately identify such similar cultivars, subtle differences between must be detected. In this study, UPLC-ESI-MS/MS-based targeted metabolomics analysis was conducted study chemical two closely related citrus reticulata ‘DHP’ C . ‘BZH’. Totally 352 metabolites including 11 terpenoids, 35 alkaloids, 80...

Abstract Chinese allegations that the United States used biological weapons against troops and Korean civilians is one of most shocking episodes War. While government repeatedly reprimanded U.S. for its uncivilized combat behavior, vigorously issued denials, treating charges as an extreme propaganda maneuver applied by China in moment military crisis, ideological fervor, political passion. Since then, a huge amount scholarship has been produced on allegation.1 None, however, provided...

Studies report that medical graduates are not prepared for practice as expected, and interventions have been developed to prepare them practice. One such intervention is the assistantship, which provides hands-on opportunities hone clinical skills undertake responsibilities under supervision. The Lee Kong Chian School of Medicine (LKCMed) Singapore's newest school, students undergo a Student Assistantship Programme (SAP) junior doctors (PGY1). This study evaluated SAP from students'...

1,5-Anhydroglucitol (1,5-AG) is a sensitive biomarker for real-time detection of diabetes mellitus. In this study, an electrochemical biosensor to specifically detect 1,5-AG levels based on persimmon-tannin-reduced graphene oxide-PtPd nanocomposites (PT-rGO-PtPd NCs), which were modified onto the surface screen-printed carbon electrode (SPCE), was designed. The PT-rGO-PtPd NCs prepared by using PT as film-forming material and ascorbic acid reducing agent. Scanning electron microscopy (SEM),...

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<title>Abstract</title> Low-carbon cities and climate resilient represent urban development models in China aimed at achieving mitigation adaptation objectives. This study focuses on the dual pilot policy of low-carbon cities, establishing a comprehensive evaluation index system for resilience that encompasses ecological, economic, social, institutional dimensions. Utilizing panel data from 286 prefecture-level above 2005 to 2021, this employs Difference-in-Differences, K-means clustering,...

Tower cranes are the most used equipment in construction projects, and path planning of tower crane operations directly affects safety performance projects. Traditional rely on only driving experience manual operators. Poor judgement bad may increase risks even cause severe accidents. To reduce operations, this research proposes a dynamic model for based computer vision technology algorithms. The proposed consists three modules: first, information collection module preprocessing video data...

Laser active imaging is widely used in many fields. The intensity image quality of laser affected by various degradations, such as speckle effect and noise. Most existing objective assessment (IQA) methods that consider only a single distorted are not suitable for an image. A multiscale full-reference IQA method presented. proposed based on improved gradient magnitude similarity deviation (GMSD) the nonsubsampled contourlet transform (NSCT) domain. reference images decomposed NSCT to emulate...

In China, the expressways have been built a lot over past decade. The construction of expressway suffers from usual cost overrun. There are many factors different stakeholders influencing expressways, and it is difficult to control all them. Therefore, necessary identify key causing overrun take corresponding measures. this article, decision-making trial evaluation laboratory (DEMATEL), interpretative structural modeling method (ISM) system dynamics (SD) integrated as DEMATEL-ISM-SD driving...

Chinese nationals who are classified as belonging to the Korean ethnic minority have become increasingly mobile since 1980s in China–North Korea borderland. ethnicity plays a significant role facilitating migration. This article unpacks mobility–ethnicity nexus through theoretical lens of ‘migration infrastructure’. To investigate how borderland residents became subjects well processes intertwined with ethnicity, ensemble technologies, institutions, and actors which migration is reproduced...

Objectives To date, most research on medical graduates’ preparedness for practice has conceptualised as something possessed by the individual. However, new doctors work within social settings with other people and, given this, we argue that a and comparative dimension. The aim of this paper is to explore students’/graduates’ self-assessments their using lens comparison theory. Setting We invited students from one Singapore’s three schools who were in final-year Student Assistantship...

The summer of 1941 was a critical juncture in WWII history. As the war intensified and threatened security United States, American people were sharply divided into two opposing political camps, one sympathetic to interventionism other favor isolationism. Frightened by recent memory WWI reality worldwide economic depression, many Americans believed that their country should separate itself from troubling events world, thereby refuting President Roosevelt’s call for America intervene against...

Abstract Background Surgery is the predominant method of treating total rectal prolapse. The transabdominal approach has advantage reducing recurrence rates compared to transperineal approach. However, former complicated and mostly applied patients with prolapse accompanied by constipation. Therefore, Laparoscopic-assisted Altemeier surgery might be a novel option for patient Case report A 40-year-old man who repeatedly suffered after defecation 3 years, was diagnosed based on physical...