A5100563074- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- GABA and Rice Research
- Metabolomics and Mass Spectrometry Studies
- Liver physiology and pathology
- Protein Tyrosine Phosphatases
- Amino Acid Enzymes and Metabolism
- Endoplasmic Reticulum Stress and Disease
- RNA and protein synthesis mechanisms
- Immune cells in cancer
- Dermatological and Skeletal Disorders
- Eicosanoids and Hypertension Pharmacology
- Circular RNAs in diseases
- Systemic Sclerosis and Related Diseases
- Advanced Nanomaterials in Catalysis
- interferon and immune responses
- Nanocluster Synthesis and Applications
- Occupational and environmental lung diseases
- Circadian rhythm and melatonin
- MicroRNA in disease regulation
- Caveolin-1 and cellular processes
- Glycosylation and Glycoproteins Research
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
Anhui Medical University
2024-2025
Taizhou Second People's Hospital
2024
First Affiliated Hospital of Anhui Medical University
2024
Beijing University of Chemical Technology
2022-2024
Tianjin Central Hospital of Gynecology Obstetrics
2023-2024
Xinjiang Medical University
2024
Nankai University
2024
Jiangnan University
2024
Zhengzhou University
2023
Shanghai Sixth People's Hospital
2023
Abstract Background and Aims Although NASH can lead to severe clinical consequences, including cirrhosis hepatocellular carcinoma, no effective treatment is currently available for this disease. Increasing evidence indicates that LSECs play a critical role in pathogenesis; however, the mechanisms involved LSEC‐mediated remain be fully elucidated. Approach Results In current study, we found LSEC homeostasis was disrupted LSEC‐specific gene profiles were altered methionine–choline‐deficient...
Th2-high asthma is characterized by elevated levels of type 2 cytokines, such as interleukin 13 (IL-13), and its prevalence has been increasing worldwide. Ferroptosis, a recently discovered programmed cell death, involved in the pathological process asthma; however, underlying mechanisms remain incompletely understood. In this study, we demonstrated that serum level malondialdehyde (MDA), an index lipid peroxidation, positively correlated with IL-13 negatively predicted forced expiratory...
Abstract Cardiac fibrosis is a pathophysiological process characterized by excessive deposition of extracellular matrix. We developed cardiac hypertrophy model using transverse aortic constriction (TAC) to uncover mechanisms relevant matrix in mouse myocardial cells. TAC caused upregulation Tripartite motif protein 72 (TRIM72), tripartite motif‐containing that critical for proliferation and migration. Importantly, vivo silencing TRIM72 reversed TAC‐induced fibrosis, as indicated markedly...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a malignancy with poor prognosis chemotherapy resistance. Here, protein arginine methyltransferase 1 (PRMT1) identified as key driver of carboplatin (CBP) resistance in HNSCC. Analyses clinical samples, lines, patient‐derived organoids, xenograft models reveal that PRMT1 promotes tumor growth CBP through novel, methyltransferase‐independent mechanism. Conditional knockout suppresses tumorigenesis enhances sensitivity vivo,...
Background Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) mediated by autoimmunity. No objective clinical indicators are available for diagnosis and prognosis MS. Extracellular proteins most glycosylated likely to enter into body fluid serve as potential biomarkers. Our work will contribute in-depth study functions extracellular discovery Methods MS expression profiling data human brain was downloaded from Gene Expression Omnibus (GEO)....
Non-alcoholic fatty liver disease (NAFLD) has become a common chronic in the world. Simple steatosis (SS) is early phase of NAFLD. However, molecular mechanisms underlying development have not yet been fully elucidated.Two public datasets (GSE48452 and GSE89632) through Gene Expression Omnibus (GEO) database were used to identify differentially expressed genes (DEGs) steatosis. A total 72 participants including 38 normal histological controls 34 SS patients included this study. ontology...
Systemic sclerosis (SSc) is a complex autoimmune disease. The pathogenesis of SSc currently unclear, although like other rheumatic diseases its complicated. However, the ongoing development bioinformatics technology has enabled new approaches to research this disease using microarray screen and identify differentially expressed genes (DEGs) in skin patients with compared individuals healthy skin. Publicly available data were downloaded from Gene Expression Omnibus (GEO) database intra‑group...
Purpose: N4-acetylcytidine (ac4C) is a post-transcriptional RNA modification catalyzed by N-acetyltransferase 10 (NAT10), critical factor known to influence mRNA stability. However, the role of ac4C in visual development remains unexplored. Methods: Analysis public datasets and immunohistochemical staining were conducted assess expression pattern nat10 zebrafish. We used CRISPR/Cas9 RNAi technologies knockout (KO) knockdown (KD) nat10, zebrafish ortholog human NAT10, evaluated its effects on...
Cerebral ischemia-reperfusion (CI/R) injury is induction of blood flow restoration after an ischemic stroke. Gentiopicroside (GPC) the principal active secoiridoid glycoside Gentiana Manshurica Kitagawa. This research aimed to illuminate function GPC and its mechanism in CI/R injury.After models were constructed, (25, 50 or 100 mg/kg) was then administered by gavage rats. Rats grouped into Sham, CI/R, CI/R+25 mg/kg GPC, CI/R+50 CI/R+100 GPC. Neuronal cells exposed oxygen-glucose deprivation...
Objective: Human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) is a new immune checkpoint in the B7 family, and value of HHLA2 small cell lung cancer (SCLC) unknown. Methods: We retrospectively detected expression by immunohistochemistry SCLC patients. Moreover, plasma biomarkers were retrospectively. Results: Seventy-four percent patients exhibited expression. staining was localised within nucleus cells, while no normal tissue specimens. The correlation between clinical...
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Summary GAD67 impacts insomnia as a key enzyme catalysing the conversion of glutamate (Glu) to gamma‐aminobutyric acid (GABA). Senegenin enhances neuroprotection and is used widely treat other neurological diseases. This study aimed investigate how senegenin regulates through GAD67‐mediated signalling pathway. We measured expression levels in patients evaluated Keap1/Nrf2/Parkin/PINK1‐related cytokines following lentiviral transfection PC12 cells rat models. also assessed cellular reactive...
ABSTRACT Glycine decarboxylase (GLDC) has been identified to be dysregulated and plays pivotal roles in various cancers. Besides, studies have suggested that GLDC expression is elevated oral squamous cell carcinoma (OSCC) associated with a worse prognosis, but the precise role molecular mechanism of OSCC remain unexplored. The current study first confirmed high its correlation survival patients OSCC. By knocking down GLDC, it was discovered growth colony formation cells, as well development...
Abstract N4-acetylcytidine (ac4C) is an epitranscriptomic modification of mRNA that catalyzed by N-acetyltransferase 10 (NAT10), a critical factor known to influence stability. However, its role in development has not been investigated. In this study, we used CRISPR/Cas9 and RNAi technology knock out down nat10 , the zebrafish ortholog human NAT10, evaluated their effects on development, behavior, transcriptome. Our findings indicate deficiency embryos results increased embryo mortality...