A5100371460- Reconstructive Surgery and Microvascular Techniques
- Reconstructive Facial Surgery Techniques
- Bone fractures and treatments
- Trauma Management and Diagnosis
- Surgical site infection prevention
- Facial Nerve Paralysis Treatment and Research
- Parkinson's Disease Mechanisms and Treatments
- Infectious Diseases and Tuberculosis
- Vascular Procedures and Complications
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Surgical Sutures and Adhesives
- Amoebic Infections and Treatments
- Tissue Engineering and Regenerative Medicine
- Neurological disorders and treatments
- Advanced Fiber Optic Sensors
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Mycobacterium research and diagnosis
- Fetal and Pediatric Neurological Disorders
- Knee injuries and reconstruction techniques
- Terahertz technology and applications
- Reproductive System and Pregnancy
- Hematological disorders and diagnostics
- Orthopedic Infections and Treatments
Chinese People's Liberation Army
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Tianjin Central Hospital of Gynecology Obstetrics
2022-2024
Nankai University
2016-2024
Longgang Central Hospital
2024
Hebei Medical University
2024
Academy of Medical Sciences
2022-2023
Academia Sinica
2022-2023
Chinese PLA General Hospital
2022-2023
First Hospital of Jilin University
2023
Mutations or inactivation of parkin, an E3 ubiquitin ligase, are associated with familial form sporadic Parkinson's disease (PD), respectively, which manifested the selective vulnerability neuronal cells in substantia nigra (SN) and striatum (STR) regions. However, underlying molecular mechanism linking parkin etiology PD remains elusive. Here we report that p62, a critical regulator for protein quality control, inclusion body formation, autophagy diverse signaling pathways, is new substrate...
Four novel N-heterocyclic carbene (NHC) silver complexes, , have been synthesized and characterized. The single X-ray crystal diffraction data indicate a dinuclear solid-state structure for mononuclear . These complexes successfully used as efficient catalysts the C-H activating carboxylation of terminal alkynes with CO2. A wide range substrates various functional groups afforded corresponding aryl or alkyl substituted propiolic acids in good yields under mild conditions. Moreover, role...
The early diagnosis and management of lung adenocarcinoma co-existing with tuberculosis (LAC-TB) presents significant challenges in clinical settings. This is compounded by a paucity robust evidence elucidating the interactions between these two conditions. study included 14 patients diagnosed LAC-TB, an equal distribution among those pulmonary (TB) peripheral lymph node TB. Controls simple TB (LAC). Histopathologic examinations confirmed typical changes each group. Immunohistochemistry...
Quercetin is a flavonoid that has anti‑inflammatory, anti‑oxidant and lipid metabolic effects. It also been reported to reduce the risk of cardiovascular disease. The present study measured effects quercetin on expression ATP‑binding cassette transporter 1 (ABCAl), sub‑family G member (ABCG1), liver X receptor‑α (LXR‑α), proprotein convertase subtilisin/kexin type 9 (PCSK9), p53, p21 p16 induced by oxidized low density lipoprotein (ox‑LDL). RAW264.7 macrophages were exposed ox‑LDL with or...
Clinical examination alone is neither sensitive nor specific for predicting flap necrosis, so several technologies, including indocyanine green angiography, thermal imaging (using the FLIR ONE), and near-infrared spectroscopy, have been developed to supplement perfusion assessment. This study aims compare accuracy of these three methods intraoperatively clinical necrosis in a rat perforator model. The authors hypothesized that assessing oxygenation rather than direct perfusion, would yield...
Spinal tuberculosis is a common extrapulmonary type that often secondary to pulmonary or systemic infections. Mycobacterium infection leads the balance of immune control and bacterial persistence. In this study, 64 patients were enrolled clinicopathological immunological characteristics different age groups analyzed. Anatomically, spinal in each group mostly occurred thoracic lumbar vertebrae. Imaging before preoperative anti-tuberculosis therapy showed proportion abscesses older was...
This clinical study describes a reconstructive method for facial soft-tissue defects that uses the pre-expanded forehead flap and minimizes donor site morbidities.The surgery was subdivided into 3 stages. First stage, an appropriately sized expander buried underneath forehead. Second after adequate inflation of expander, based on frontal branches superficial temporal artery raised, distal portion used to reconstruct defect. The cutaneous pedicle designed near hairline. Third weeks later,...
Excessive beta band (13-30 Hz) oscillations have been observed in the basal ganglia (BG) of patients with Parkinson's disease (PD). Understanding origin and transmission are important to improve treatments PD, such as closed-loop deep brain stimulation (DBS). This paper proposed a model-based GPi system suppress pathological BG. The feedback nucleus was selected through analysis variation when different synaptic currents were blocked, mainly projections from globus pallidus external (GPe),...
The special blood circulation, anatomy, and tissue structure of the spine may lead to significant differences in pathological features drug resistance between spinal tuberculosis pulmonary tuberculosis. Here, we collected 168 cases 207 cases, compared their clinical as well resistance. From anatomical location, highest incidence was lumbar tuberculosis, followed by thoracic PET-CT scans showed increased FDG uptake diseased vertebrae, discernible peripheral soft shadow, visible internal...
Rationale: As a paraneoplastic syndrome, Trousseau syndrome (TS) is collective term for various thromboembolic events caused by clotting and fibrinolytic abnormalities in patients with tumors, clinically manifesting as venous arterial thromboembolism, well disseminated intravascular coagulation (DIC). The incidence rate of thrombosis TS 2% to 5%. Patient concerns: This article reports 2 TS-induced cerebral infarction. One patient had been definitively diagnosed cervical adenosquamous...
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with poor prognosis. The disease originates from the cortex of adrenal gland and lacks effective treatment. Efforts have been made to elucidate pathogenesis ACC, but molecular mechanisms remain elusive. To identify key genes pathways in expression profiles GSE12368, GSE90713 GSE143383 were downloaded Gene Expression Omnibus (GEO) database. After screening differentially expressed (DEGs) each microarray dataset on basis cut-off, we...
This clinical study aimed at introducing a reconstructive method for total cheek soft tissue defects using the pre-expanded medial arm flap and to maximally reduce donor site morbidities simultaneously. A retrospective review of data was performed 3 patients requiring reconstruct defects. The in primarily closed pedicle parascapular or thoracodorsal artery perforator flap. All had unilateral defect after lesion removal. Three flaps measuring 17 × 11 cm, 22 15 20 cm were separately used...
Abstract Preeclampsia (PE) is the most common medical complication during pregnancy and second leading cause of maternal death worldwide. However, a better predictive model PE remains to be explored. A total 15 severe preeclampsia (sPE) 75 healthy control patients were included in this study. Patient data was obtained from September 2019 2021. Nuchal translucency (NT) crown‐rump length (CRL) fetus acquired by ultrasound. Maternal blood samples collected at 11 +0 13 +6 weeks gestation....
Abstract The tissues of the medial arm as a donor site for perforator flap design have several advantages. However, they are relatively underused with limited reports, partly due to unreliable anatomy. Therefore, we aimed review our preliminary experience using indocyanine green (ICG) angiography and elevate preexpanded pedicled brachial artery (BAP) flaps regional reconstruction. All patients underwent soft tissue reconstructions BAP in two or three stages. ICG was used localize perforators...
Background The latissimus dorsi myocutaneous flap is widely used in reconstructive surgery; however, primary donor-site closure remains challenging when a wide harvested. Methods A large was elevated and transferred to repair defects. Perforators adjacent the donor site of were explored using an ultrasound Doppler probe or technique extensive exploration along margins wound. single multiple perforator propeller flaps based on these perforators close defect. Results From June 2012 April 2018,...
Previously reported pre-expansion techniques of the anterolateral thigh flap are mainly perforator-based. The expansion will interfere with harvest if requisite perforator is found unsuitable as a pedicle. Expansion peripheral territories donor site can minimize interference from expansion.Forty-eight pre-expansions were retrospectively reviewed in 38 patients 2012 to 2021. reconstructive outcomes, including success, increase size, donor-site closure, and complications, assessed. In...