A5076610659- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Tuberous Sclerosis Complex Research
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Cardiac tumors and thrombi
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Mast cells and histamine
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- Plant Stress Responses and Tolerance
- Signaling Pathways in Disease
- Wnt/β-catenin signaling in development and cancer
- Genetic Mapping and Diversity in Plants and Animals
- Plant Reproductive Biology
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Plant-Microbe Interactions and Immunity
- Polyamine Metabolism and Applications
- Plant Molecular Biology Research
- Medicinal plant effects and applications
- Photosynthetic Processes and Mechanisms
- Fibroblast Growth Factor Research
Anhui Medical University
2016-2025
Bozhou People's Hospital
2024-2025
First Affiliated Hospital of Anhui Medical University
2017-2025
Zhejiang Normal University
2009-2024
Ministry of Education of the People's Republic of China
2011-2016
State Key Laboratory of Genetic Engineering
2009-2012
Fudan University
2009-2012
Sichuan Cancer Hospital
2012
Chinese Academy of Medical Sciences & Peking Union Medical College
2011
Peking Union Medical College Hospital
2010-2011
Although aerobic glycolysis (the Warburg effect) is a hallmark of cancer, key questions, including when, how, and why cancer cells become highly glycolytic, remain less clear. For largely unknown regulatory mechanism, rate-limiting glycolytic enzyme pyruvate kinase M2 (PKM2) isoform exclusively expressed in embryonic, proliferating, tumor cells, plays an essential role metabolism growth. Because the receptor tyrosine kinase/PI3K/AKT/mammalian target rapamycin (RTK/PI3K/AKT/mTOR) signaling...
Long noncoding RNAs (lncRNAs) are essential regulators of gene expression in eukaryotes. Despite increasing knowledge on the function lncRNAs, little is known about their effects crop yield. Here, we identify a lncRNA transcribed from antisense strand neighbouring LRK (leucine-rich repeat receptor kinase) cluster named LAIR (LRK Antisense Intergenic RNA). overexpression increases rice grain yield and upregulates several genes. Additionally, chromatin immunoprecipitation assay results...
The dysregulated mechanistic target of rapamycin complex 1 (mTORC1) signaling plays a critical role in ferroptosis resistance and tumorigenesis. However, the precise underlying mechanisms still need to be fully understood. Endoplasmic reticulum oxidoreductase alpha (ERO1α) expression mTORC1-activated mouse embryonic fibroblasts, cancer cells, laryngeal squamous cell carcinoma (LSCC) clinical samples was examined by quantitative real-time PCR (qRT-PCR), western blotting, immunofluorescence...
The receptor tyrosine kinase/PI3K/AKT/mammalian target of rapamycin (RTK/PI3K/AKT/mTOR) pathway is frequently altered in cancer, but the underlying mechanism leading to tumorigenesis by activated mTOR remains less clear. Here we show that a positive regulator Notch signaling mouse and human cells, acting through induction STAT3/p63/Jagged cascade. Furthermore, response differential cues from mTOR, found served as molecular switch shift balance between cell proliferation differentiation. We...
Abstract Mammalian target of rapamycin (mTOR) is a major downstream effector the receptor tyrosine kinase (RTK)–phosphoinositide 3-kinase (PI3K)–v-akt murine thymoma viral oncogene homologue 1 (AKT) signaling pathway. Although this network frequently altered in cancer, underlying mechanisms that cause tumorigenesis as result activated mTOR remain largely unknown. We report here expression lactate dehydrogenase B (LDHB), critical enzymatic activator glycolysis, was upregulated an...
Th2-high asthma is characterized by elevated levels of type 2 cytokines, such as interleukin 13 (IL-13), and its prevalence has been increasing worldwide. Ferroptosis, a recently discovered programmed cell death, involved in the pathological process asthma; however, underlying mechanisms remain incompletely understood. In this study, we demonstrated that serum level malondialdehyde (MDA), an index lipid peroxidation, positively correlated with IL-13 negatively predicted forced expiratory...
Recently, an increasing number of studies have suggested that mTOR plays a critical role in the regulation tumor cell motility, invasion and cancer metastasis. However, little is known about signaling mechanisms regulating epithelial–mesenchymal transition (EMT) prostate cancer. In this study, we found expression levels Raptor Rictor tissues were elevated, which may suggest pathways are associated with progression Inhibition mTORC1 or mTORC2 by knock down Rictor, respectively, migration...
Drought represents a key limiting factor of global crop distribution. Receptor-like kinases play major roles in plant development and defence responses against stresses such as drought. In this study, LRK2, which encodes leucine-rich receptor-like kinase, was cloned characterized found to be localized on the plasma membrane rice. Promoter-GUS analysis revealed strong expression tiller buds, roots, nodes anthers. Transgenic plants overexpressing LRK2 exhibited enhanced tolerance drought...
Aberrantly activated mammalian target of rapamycin complex 1 (mTORC1) plays a vital role in tumor angiogenesis, but its precise mechanisms are still unclear.
Background: Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors head and neck, it has shown increasing incidence mortality.The mechanistic target rapamycin complex 1 (mTORC1) frequently dysregulated in LSCC, but its underlying mechanisms remain unclear.Methods: Establishment a novel LSCC line using primary tumor tissues with mTORC1 activity then stable knockdown Raptor (an specific component) this line.Transcriptomic sequencing, quantitative real-time PCR,...
Abstract Increased inflammatory responses and oxidative stress at the wound site following skin trauma impair healing. Furthermore, scarring places fibroblasts under severe mechanical aggravates pathological fibrosis. A novel liposomal composite hydrogel is engineered for microenvironment remodeling, incorporating dual‐loaded liposomes into gelatin methacrylate to create a nanocomposite hydrogel. Notably, tetrahydrocurcumin (THC) hepatocyte growth factor (HGF) are encapsulated in hydrophobic...
Abstract Breast cancer (BC) remains a significant health concern for women globally, prompting the relentless pursuit of novel therapeutic modalities. As traditional Chinese medicine, Boswellia carterii has been extensively used to treat various cancers, such as BC. However, anti-BC effect and underlying mechanism remain largely unclear. The aim this study is explore n-hexane extract (BCHE) against BC well its mechanism. present showed that BCHE significantly suppressed viability human...
Abstract Background The aberrant expression of phosphofructokinase-platelet (PFKP) plays a crucial role in the development various human cancers by modifying diverse biological functions. However, precise molecular mechanisms underlying PFKP head and neck squamous cell carcinoma (HNSCC) are not fully elucidated. Methods We assessed levels c-Myc tumor adjacent normal tissues from 120 HNSCC patients. A series vitro vivo experiments were performed to explore impact feedback loop between on...
In rice (Oryza sativa L.), the number of panicles, spikelets per panicle and grain weight are important components yield. These characteristics controlled by quantitative trait loci (QTLs) derived from variation inherent in crops. As a result complex genetic basis these traits, only few genes involved their control have been cloned characterized. We previously map-cloned gene cluster including eight leucine-rich repeat receptor-like kinase (LRK) Dongxiang wild rufipogon Griff.), which...
Frequent alteration of upstream proto-oncogenes and tumor suppressor genes activates mechanistic target rapamycin (mTOR) causes cancer. However, the downstream effectors mTOR remain largely elusive. Here we report that brain-expressed X-linked 2 (BEX2) is a novel effector mTOR. Elevated BEX2 in Tsc2−/− mouse embryonic fibroblasts, Pten−/− Tsc2-deficient rat uterine leiomyoma cells, brains neuronal specific Tsc1 knock-out mice were abolished by inhibitor rapamycin. Furthermore, was also...
Abstract Several different mutations in the proteome of centriole 1 centriolar protein B (POC1B) have been linked to cone dystrophy or cone-rod (CORD). However, POC1B that are associated with both CORD and oligoasthenoteratozoospermia (OAT) not reported previously. Here, whole-exome sequencing was performed identify a homozygous frameshift variant (c.151delG) two brothers who had diagnosed OAT from consanguineous family. Transcript analyses biological samples patients carrying showed is lost...
Abstract Background Although hepatitis B virus (HBV) infection is a major risk factor for hepatic cancer, the majority of HBV carriers do not develop this lethal disease. Additional molecular alterations are thus implicated in process liver tumorigenesis. Since phosphatase and tensin homolog (PTEN) decreased approximately half cancers, we investigated significance PTEN deficiency HBV-related hepatocarcinogenesis. Methods HBV-positive human cancer tissues were checked expression. Transgenic ,...
Abstract As evidenced by the behavior of loss-of-function mutants PTEN in context a gain-of-function mutation AKT1, PTEN-AKT1 signaling pathway plays critical role human cancers. In this study, we demonstrated that deficiency or activation AKT1 potentiated expression platelet-derived growth factor receptor α (PDGFRα) based on studies Pten−/− mouse embryonic fibroblasts, cancer cell lines, hepatic tissues Pten conditional knockout mice, and tissues. Loss enhanced PDGFRα via AKT1-CREB cascade....
Abstract Background Usenamine A, a novel natural compound initially isolated from the lichen Usnea longissima , has exhibited promising efficacy against hepatoma in prior investigation. Nevertheless, underlying mechanisms responsible for its antihepatoma effects remain unclear. Furthermore, role of AKT/mechanistic target rapamycin (mTOR)/signal transducer and activator transcription 3 (STAT3)/inhibitor differentiation/DNA binding 1 (ID1) signaling axis hepatocellular carcinoma (HCC),...
Head and Neck Squamous Cell Carcinoma (HNSCC) presents significant challenges in terms of treatment prognosis, highlighting the urgent need for new therapeutic targets development effective targeted therapies to enhance patient outcomes survival. The expression level RBMS1 HNSCC was identified by GEO TCGA databases through systematic bioinformatics analysis, further verified human specimens quantitative Real-time PCR, Western blot, immunohistochemistry. results CCK-8, colony formation assay,...