A5100661589- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cancer-related gene regulation
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
- Circular RNAs in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Cleft Lip and Palate Research
- Cell Adhesion Molecules Research
- RNA and protein synthesis mechanisms
- Developmental Biology and Gene Regulation
- Clinical practice guidelines implementation
- Thyroid Cancer Diagnosis and Treatment
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Hearing, Cochlea, Tinnitus, Genetics
- Kruppel-like factors research
- Lung Cancer Research Studies
- TGF-β signaling in diseases
First Affiliated Hospital of Bengbu Medical College
2008-2025
Qingdao University
2024-2025
Affiliated Hospital of Qingdao University
2024-2025
Jinan University
2021
Bengbu Medical College
2015
Abstract Long noncoding RNAs (lncRNAs) are emerging as important regulators in the development of cancer cells. However, role and mechanisms most lncRNAs papillary thyroid carcinoma (PTC) remain unknown. In this study, we investigated lncRNA expression profiles PTC using RNA-seq two groups tissues adjacent normal tissues, validated by real-time PCR analysis another 53 pairs tissues. We identified a novel lncRNA, n384546, which is highly expressed cell lines. n384546 was associated with...
Background: The atherogenic index of plasma (AIP) is considered an important marker atherosclerosis and cardiovascular risk. However, its potential role in predicting length stay (LOS), especially patients with atherosclerotic disease (ASCVD), remains to be explored. We investigated the effect AIP on hospital LOS critically ill ASCVD explored risk factors affecting conjunction machine learning.
Abstract Objective The causality between CMD and sepsis has remained largely unknown. To elucidate this, we conducted a Mendelian randomization (MR) population study. Methods Firstly, used univariable multivariable MR analyses to investigate causal associations sepsis-related outcomes. We obtained Genome-wide association study summary from both the MRC Integrative Epidemiology Unit FinnGen consortium. Subsequently, two-step mediation analysis was performed explore mediators. Afterward, an...
The atherogenic index of plasma (AIP) is considered an important marker atherosclerosis and cardiovascular risk. However, its potential role in predicting length stay (LOS), especially patients with atherosclerotic disease (ASCVD), remains to be explored. We investigated the effect AIP on hospital LOS critically ill ASCVD explored risk factors affecting conjunction machine learning. Using data from Medical Information Mart for Intensive Care (MIMIC)-IV. was calculated as logarithmic ratio TG...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a malignancy with poor prognosis chemotherapy resistance. Here, protein arginine methyltransferase 1 (PRMT1) identified as key driver of carboplatin (CBP) resistance in HNSCC. Analyses clinical samples, lines, patient‐derived organoids, xenograft models reveal that PRMT1 promotes tumor growth CBP through novel, methyltransferase‐independent mechanism. Conditional knockout suppresses tumorigenesis enhances sensitivity vivo,...
Hox genes, a highly conserved homolog in most animals, play vital functions cell development and organ formation. In recent years, researchers have discovered that it can act as tumor regulator, its members participate tumorigenesis by regulating receptor signaling, differentiation, apoptosis, migration, EMT, angiogenesis. genes which major role the progress of head neck squamous carcinoma (HNSCC) is still unclear. After analyzing expression differences prognostic value all through TCGA-HNSC...
Introduction: tRNA-derived small RNAs (tsRNAs), a class of non-coding RNAs, are divided into two categories: tRNA-related fragments (tRFs) and tRNA halves (tiRNAs). Abnormal expression tsRNAs has been found in diverse cancers, which indicates that further understanding the function will help identify new biomarkers potential therapeutic targets. Until now, underlying roles primary nasopharyngeal carcinoma (NPC) still unknown. Methods: tRF tiRNA sequencing was performed on four pairs NPC...
To investigate the correlations of miR-31 expression with cell proliferation, invasion, and prognosis patients head neck squamous carcinoma (HNSCC).The in human laryngeal cancer TU686 cells, nasopharyngeal CNE-2 normal oral keratinocyte (NHOK) epithelial cells was detected via quantitative real-time polymerase chain reaction (qRT-PCR). The effects on proliferation invasion HNSCC were explored through transfecting analogs (miR-31 mimics) inhibitors (anti-miR-31). qRT-PCR applied to detect...
Hypopharyngeal cancer is a distinct type of malignant head and neck tumor, which exhibits low sensitivity to anti-cancer drugs. The importance developing methods for reducing chemotherapy resistance, improving enhancing prognosis has previously been emphasized considered challenge effective clinical treatment hypopharyngeal cancer. current study investigated the effects co‑expression inhibitor growth protein 4 (ING4) P53, tumor suppressor gene, on chemosensitivity cisplatin in human...
Abstract Recent evidence suggests that ferroptosis plays a crucial role in the occurrence and development of white matter lesions. However, mechanisms regulatory pathways involved within lesions remain unclear. Long non-coding RNAs (lncRNAs) have been shown to influence these We previously identified lnc_011797 as biomarker by high-throughput sequencing. To investigate mechanism which regulates lesions, we established subjected human umbilical vein endothelial cells oxygen-glucose...
Objectives: Recent publications reported that patients with rheumatoid arthritis (RA) experience an increased risk of suffering sudden sensorineural hearing loss (SSNHL), however, these cases are poorly understood. This study aims to explore the clinical presentations and recovery SSNHL RA. Study Design: Retrospective study. Setting: Tertiary medical center. Patients: Forty-seven RA (RA group) 431 without (non-RA were recruited between April 2015 June 2019. Interventions: In non-RA group,...
RNA binding motif protein 17 (RBM17) is a protein-coding gene. The encoded by RBM17 involved in the regulation of alternative splicing and overexpressed cancer. present study aimed to determine effect RBM17-knockdown hypopharyngeal carcinoma FaDu cells using lentivirus-mediated shRNA method. Cell proliferation was detected an MTT assay. Flow cytometry analysis used cell cycle distribution apoptosis. results demonstrated that expression significantly decreased infected with lentivirus-shRNA....
Abstract Background and aim: Sex-determining region-Y-related high-mobility-group box 4 (SOX4) is associated with the metastasis prognosis of many cancer types. However, studies on role SOX4 in laryngeal squamous cell carcinoma (LSCC) are few, hence mechanism unclear. Epithelial–mesenchymal transition (EMT) allows neoplastic cells to gain plasticity motility required for tumor progression metastasis. This study aimed analyze relationship between EMT, their clinicopathological factors related...
The aim of this study was to investigate KAI1/CD82 protein expression in human nasopharyngeal carcinoma (NPC) cell lines and NPC tissues. Immunohistochemistry western blot analysis were used detect the localization levels five lines. also conducted 70 tissues 30 non-neoplastic found decrease as metastatic potential cells increased. rate (44.3%) significantly lower than that (70.0%) (P<0.05). not associated with clinical parameters, including gender, age, histological type T stage, positive...
Most of advanced hypopharyngeal squamous cell carcinoma (HSCC) are resistant to chemotherapy, and there is still lack effective treatment for HSCC now. The present study aimed investigate whether downregulation RNA-binding motif protein 17 (RBM17) could enhance cisplatin sensitivity inhibit invasion in the underlying mechanism. We observed that RBM17 was upregulated tumor tissues associated with poor progression. Treatment FaDu cells increased expression mRNA levels. Downregulation enhanced...
Abstract The inhibitor of growth family member 4 ( ING4 ) is one the ING genes, serves as a repressor angiogenesis or tumour and suppresses loss contact inhibition. Oncostatin M (OSM) multifunctional cytokine that belongs to interleukin (IL)‐6 subfamily with several biological activities. However, role recombinant adenoviruses co‐expressing OSM (Ad‐ING4‐OSM) in anti‐tumour activity laryngeal cancer has not yet been identified. Recombinant Ad‐ING4‐OSM was used evaluate their combined effect...
This study aimed to explore the role of lncRNA MALAT1 (Long non-coding RNAs metastasis-associated lung adenocarcinoma transcript), and its underlying mechanisms in Hypopharyngeal Squamous Cell Carcinoma (HSCC). Quantitative real-time PCR (qRT-PCR) was employed measure expression HSCC adjacent non-cancerous tissues, along with downstream target mitogen-activated protein kinase 1 (MAP2K1). The independent prognostic significance assessed using Cox regression analysis. Potential targets were...
Objective To explore the incidence and factors of paranasal sinusitis among nasopharyngeal carcinoma (NPC) patients after radiotherapy. Methods Retrospectively evaluated clinical data 144 NPC without before radiotherapy, including 82 cases in T1/T2 stage 62 T3/T4 treated First Affiliated Hospital Bengbu Medical College from 2000 to 2005. MRI images radiotherapy were compared. The analyzed. There 58 nasal invasion. Nasopharyngeal was given at face-neck joint portal with 6 MV X-ray...