A5100663489- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- RNA Research and Splicing
- Fibroblast Growth Factor Research
- Parathyroid Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Electrochemical sensors and biosensors
- Ginseng Biological Effects and Applications
- Cancer Research and Treatments
- Biomarkers in Disease Mechanisms
- Proteoglycans and glycosaminoglycans research
- Robotics and Automated Systems
- Circular RNAs in diseases
- Thyroid Cancer Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Cancer-related Molecular Pathways
- Geological Modeling and Analysis
- Natural product bioactivities and synthesis
- Medicinal Plant Pharmacodynamics Research
- Glutathione Transferases and Polymorphisms
- Craniofacial Disorders and Treatments
- Mercury impact and mitigation studies
- Robotics and Sensor-Based Localization
- Metabolism, Diabetes, and Cancer
Xinyang College of Agriculture and Forestry
2023
Peking University
2022
Shanghai Jiao Tong University
2015-2021
Renji Hospital
2007-2020
The University of Texas MD Anderson Cancer Center
2014
The purposes of this study were to investigate the potential roles long noncoding RNA (lncRNA) PVT1 in thyroid cancer cell proliferation and explore their possible mechanisms. A total 84 patients who diagnosed as having (papillary carcinoma (PTC), follicular (FTC), anaplastic (ATC)) Renji Hospital enrolled study. Expressions lncRNA tissues lines (IHH-4, FTC-133, 8505C) analyzed using RT-polymerase chain reaction (PCR) western blotting analysis. effects expression on cycle flow cytometry....
PTEN [phosphatidylinositol (3,4,5)-trisphosphate phosphatase and tensin homolog deleted from chromosome 10], a critical tumor suppressor, is regulated by numerous post-translational modifications, including phosphorylation, ubiquitination, acetylation, SUMOylation, which affect localization protein stability. Here we report ADP-ribosylation as new modification of PTEN. We identified novel substrate tankyrases, are members the poly(ADP-ribose) polymerases (PARPs). showed that tankyrases...
Abstract Long noncoding RNAs (lncRNAs) are emerging as important regulators in the development of cancer cells. However, role and mechanisms most lncRNAs papillary thyroid carcinoma (PTC) remain unknown. In this study, we investigated lncRNA expression profiles PTC using RNA-seq two groups tissues adjacent normal tissues, validated by real-time PCR analysis another 53 pairs tissues. We identified a novel lncRNA, n384546, which is highly expressed cell lines. n384546 was associated with...
Papillary thyroid carcinoma (PTC) and benign adenoma (BTA) are the most common head neck tumors. However, metabolic differences between PTC BTA have not been characterized. The aim of this study was to identify profiles these two types tumors using a metabolomics approach. Tumors adjacent nontumor specimens collected from 57 patients with 48 were profiled gas chromatography-time-of-flight mass spectrometry ultraperformance liquid chromatography-quadrupole time-of-flight spectrometry. A panel...
Background Poor postoperative wound healing after endoscopic sinus surgery (ESS) remains a significant problem. This study evaluates the efficacy and safety of new absorbable hyaluronan hydrogel. Methods A prospective, randomized, controlled trial was conducted. Fifty-five patients with bilateral ESS were recruited randomized to receive hydrogel in one side as treated opposite without control. Clinical outcome measures assessed at 1, 2, 4, 8, 12 weeks. Results Fifty-four completed study....
Abstract Objective To assess the capacity of support vector machine (SVM) algorithms that are developed based on platelet RNA-seq data in identifying thyroid neoplasm patients and differentiating with adenomas, papillary cancer metastasized cancer. Methods Platelets were collected isolated from 109 63 healthy controls. was performed to find transcripts differential levels. Genes corresponding these altered identified using R packages. All samples subsampled into a training set validation...
Background: Endothelial dysfunction is commonly accompanied by a reduced capacity for nitric oxide (NO) production and decreased NO sensitivity, playing central role in numerous vascular diseases. Saturated free fatty acids are known to reduce then induce endothelial dysfunction. Alternative splicing participates the regulation of cellular tissular homeostasis highly regulated serine-arginine protein kinase (SRPK1). The SRPK1 biology cells remains elusive. Icariside Ⅱ (ICA Ⅱ) has been...
This study aimed to compare the postoperative effects of total parathyroidectomy plus forearm transplantation and radioguided on bone metabolism mineral density (BMD). From June 2013 October 2017, 67 patients with renal secondary hyperparathyroidism (SHPT) received surgical treatment. The control group included 30 cases classical for SHPT. In experimental group, 37 underwent 99mTc-MIBI-guided parathyroidectomy. Demographics, parathyroid hormone (PTH) level, blood calcium pathological results...
Image-guided computer-aided surgery (ICAS) contributes to the safety and success of surgical operations by means displaying anatomical structures showing correlative information surgeons while they perform an operation. Based on analysis requirements for ICAS, this paper proposes a new concept medical-knowledge-based ICAS. The traditional data structure is limited in expressing reusing medical knowledge such as locating object, topological relations objects attributes. This outlines...
Objective:To compare the different therapeutic effects of modified syringe forearm quantitative injection and brachioradialis intramuscular transplantation after receiving total parathyroidectomy in patients with secondary hyperparathyroidism. Method:One hundred fifty-two hyperparathyroidism who underwent were divided into group according to methods. The study counted compared duration surgery, preoperative postoperative parathyroid hormone levels, blood calcium other indicators. Result:The...
To analyze the metabolic profiles of female papillary thyroid carcinoma (PTC) and relationship between primary tumor size cervical lymph node metastasis using a metabolomics approach.Forty-three cases PTC were enrolled in this study. Gas chromatography-time-of-flight mass spectrometry ultra performance liquid chromatography-time flight-mass employed for analyzing tissues adjacent normal PTC. Cases divided into Group T1 (tumor size≤2.0 cm) T2 size>2.0 according to size, N- (with negative...
Image-guided computer-aided surgery (ICAS) contributes to the safety and success of surgical operations by means displaying anatomical structures showing correlative information surgeons while they perform an operation. Based on analysis requirements for ICAS, this paper proposes a new concept medical-knowledge-based ICAS. The traditional data structure is limited in expressing reusing medical knowledge such as locating object, topological relations objects attributes. This outlines...