A5108056331- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Medicinal Plant Pharmacodynamics Research
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Lung Cancer Research Studies
- Natural product bioactivities and synthesis
- RNA Research and Splicing
- Metabolism, Diabetes, and Cancer
- Mechanisms of cancer metastasis
- Signaling Pathways in Disease
- NF-κB Signaling Pathways
- Plant responses to water stress
- Cancer Risks and Factors
- Neuroinflammation and Neurodegeneration Mechanisms
- Machine Learning in Bioinformatics
- Sexual function and dysfunction studies
- Sperm and Testicular Function
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Circular RNAs in diseases
- FOXO transcription factor regulation
First Hospital of Jiaxing
2019-2025
Zhongda Hospital Southeast University
2025
Peking University
2021-2023
Peking University International Hospital
2023
Yangzhou University
2023
Peking University First Hospital
2021-2022
Peking University People's Hospital
2022
Capital Medical University
2021
Zhejiang University
2018
First Affiliated Hospital Zhejiang University
2017
Objective Small-cell lung cancer (SCLC) remains challenging to treat due its high invasiveness and propensity for drug resistance. Evidence suggests that the regulatory relationship between metallothionein 2A (MT2A) yes-associated protein 1 (YAP1) signaling pathway may influence development of SCLC. Therefore, this study aims explore potential mechanisms affecting SCLC progression based on interaction YAP1 MT2A. Material Methods This utilized reverse transcription quantitative polymerase...
Adipose tissue activation plays a positive role in breast cancer outcomes, consistent with the improved outcomes observed through exercise and weight loss mediated by brown beige fat. However, underlying mechanism of this process remains unclear. C-terminal fragment Slit2 (Slit2-C), endogenously produced or adipose cells could increase thermogenic autocrine paracrine manners. Here, we show that Slit2-C dominantly reduces cell invasion cAMP/PKA inhibition epithelial-mesenchymal transition. In...
MADS-box transcription factors are crucial members of regulatory networks underlying multiple developmental pathways and abiotic stress in plants. Studies on resistance-related functions genes very limited barley. To gain insight into this gene family elucidate their roles salt waterlogging resistance, we performed genome-wide identification, characterization expression analysis A whole-genome survey barley revealed 83 genes, which were categorized type I (Mα, Mβ Mγ) II (AP1, SEP1, AGL12,...
Purpose To assess the diverse cell populations of human corpus cavernosum in patients with severe erectile dysfunction (ED) at single-cell level. Methods Penile tissues collected from three were subjected to RNA sequencing using BD Rhapsody™ platform. Common bioinformatics tools used analyze cellular heterogeneity and gene expression profiles generated raw data, including packages Seurat, Monocle, CellPhoneDB. Results Disease-related types was determined cavernous tissue such as endothelial...
Background: Endothelial dysfunction is commonly accompanied by a reduced capacity for nitric oxide (NO) production and decreased NO sensitivity, playing central role in numerous vascular diseases. Saturated free fatty acids are known to reduce then induce endothelial dysfunction. Alternative splicing participates the regulation of cellular tissular homeostasis highly regulated serine-arginine protein kinase (SRPK1). The SRPK1 biology cells remains elusive. Icariside Ⅱ (ICA Ⅱ) has been...
Bovine milk-derived extracellular vesicles (BM-EVs) are recognized as promising nanoscale delivery vectors owing to their large availability. However, few isolation methods can achieve high purity and yield simultaneously. Therefore, we developed a novel cost-effective procedure separate BM-EVs via "salting-out." First, were isolated from skimmed milk using ammonium sulfate. The majority of precipitated between 30 40% saturation 34% had relatively augmented purity. separated showed spherical...
Testicular endothelial cells have been found to play an important role in spermatogenesis and fertility, but their mechanism is obscure. Exosomes released by various are recognized as cell–cell communication mediators during the initiation progression of many diseases. Therefore, current study aimed investigate protein miRNA components human testicular cell-derived exosomes (HTEC-Exos) explore potential effects on spermatogenesis. In this study, HTEC-Exos were first isolated...
Lipopolysaccharide is a major constituent of the outer membrane Gram-negative bacteria. It activates monocytes and macrophages to produce cytokines such as tumor necrosis factor-alpha interleukins IL-1beta IL-6. These appear be responsible for neurotoxicity observed in peripheral nervous system inflammatory disease. has been reported that, central system, expression level intercellular adhesion molecule-1 (ICAM-1) was dramatically upregulated response LPS, well many cytokines. ICAM-1...
Palmitic acid (PA) has a lipotoxic effect on blood vessels, leading to endothelial dysfunction and cell death. The underlying mechanisms are not yet fully understood.We sought investigate the effects of PA cells, with an emphasis ferroptosis.Rat corpus cavernosum cells (RCCECs) human umbilical vein (HUVECs) were treated induce pattern death, as evidenced by evaluation viability. differentially expressed genes measured via RNA sequencing reveal potential mechanisms. intracellular levels...
Icariside II, as a favonoid compound derived from epimedium, has been proved to involed in variety of biological and pharmacological effects such anti-inflammatory, anti-osteoporosis, anti-oxidation, anti-aging, anti-cancer but its mechanism is unclear, especially terms effect on post-transcriptional modification endothelial nitric oxide synthase (eNOS). Phosphorylation eNOS plays an important role the synthesis cells, which closely related erectile dysfunction, atherosclerosis, Alzheimer’s...
<title/>The injuries of the peripheral nerve are results trauma, disease, and surgical procedures that require section nerves to gain access site. Unlike elements central nervous system, can regenerate when damaged. Recent studies provide evidence intercellular adhesion molecule-1 (ICAM-1) is involved not only in inflammation, but also cell recruitment during Wallerian degeneration after injury. In our studies, two different injury models (crush transect) for regeneration were used. We...
COPD (chronic obstructive pulmonary disease) and ILD (interstitial lung are two common respiratory disease. They share similar clinical traits but require different therapeutic treatments. Identify the biomarkers that differentially expressed between them will not only help diagnosis of ILD, also provide candidate drug targets may facilitate development new treatment for ILD. Due to irreversible complex pathological changes COPD, there is very limited options patients. In this study, we...
Objective To explore the diagnosis and management of functional pancreatic endocrine tumor. Methods Clinical data 19 cases tumor were retrospectively analyzed. Results 15 insulinoma, 2 gastrinoma glucagonoma qualitatively diagnosed. The positive rate preoperative diagosis for type B ultrasonic inspection, CT, MRI, EUS, selective portovenous sampling intraoperative inspection was 15.8% (3/19) , 67.5% (10/16) 71.4% (5/7) 87.5% (7/8) 100% (2/2) 85.7% (6/7) respectively. Of total...
Idiopathic pulmonary fibrosis (IPF) is an agnogenic chronic interstitial pneumonia, characterized by fibrosis, differentiation of myofibroblasts, deposition extracellular matrix, finally leads to distortion lung architecture and insufficiency respiratory.Once diagnosed IPF, the treatment options are limited.The unknown microdamage alveolar has been regarded as initial factor consequently activation transforming growth factor-β destruction basement membrane.The activated can induce apoptosis...