A5100663492- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Advanced Photocatalysis Techniques
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Asymmetric Hydrogenation and Catalysis
- Autophagy in Disease and Therapy
- Organometallic Complex Synthesis and Catalysis
- Sirtuins and Resveratrol in Medicine
- Synthesis and characterization of novel inorganic/organometallic compounds
- Thyroid Cancer Diagnosis and Treatment
- Wildlife Ecology and Conservation
- Rangeland Management and Livestock Ecology
- Radioactive element chemistry and processing
- Hearing, Cochlea, Tinnitus, Genetics
- Ferroelectric and Piezoelectric Materials
- Catalytic Processes in Materials Science
- BRCA gene mutations in cancer
- Head and Neck Cancer Studies
- Species Distribution and Climate Change
- Nanoplatforms for cancer theranostics
- RNA Research and Splicing
- Sinusitis and nasal conditions
- Chromosomal and Genetic Variations
- PARP inhibition in cancer therapy
Jiaxing University
2025
Renji Hospital
2025
Shanghai Jiao Tong University
2025
Soochow University
2024
Xidian University
2024
Southeast University
2020-2023
Zhongda Hospital Southeast University
2023
Peking University
2015-2023
Peking University Cancer Hospital
2023
Molecular Oncology (United States)
2023
SIRT7 plays a critical role in dissembling and deactivating ATM when DNA damage repair is completed.
In this work, hydrothermally prepared p–n heterojunction BiOBr/SnO2 photocatalysts were applied to eliminate NO in visible light. The as-synthesized exhibit superior photocatalytic activity and stability through the establishment of a heterojunction, resulting significant improvement charge separation transfer properties. morphological structure optical property also investigated comprehensively. Extended light absorption into range was achieved by SnO2 coating on surface BiOBr microsphere...
The histone acetyltransferase TIP60, a frequent target of monoallelic loss in human carcinomas, can acetylate many substrates, including histones and p53, thus promote apoptosis following UV radiation. Here we showed that TIP60 is autoacetylated response to damage, which critically important for activation. Mechanistically demonstrated autoacetylation leads the dissociation oligomer enhances its interaction with substrates. Moreover, identified SIRT1 specifically deacetylates negatively...
Mutation of PHF6, which results in the X-linked mental retardation disorder Börjeson-Forssman-Lehmann syndrome, is also present about 38% adult T-cell acute lymphoblastic leukemias and 3% myeloid leukemias. However, it remains to be determined exactly how PHF6 acts vivo what functions may associated with its putative tumor suppressor function. Here, we demonstrate that a nucleolus, ribosomal RNA promoter-associated protein. directly interacts upstream binding factor (UBF) through PHD1 domain...
The RPA complex can integrate multiple stress signals into diverse responses by activating distinct DNA repair pathways. However, it remains unclear how RPA1 elects to activate a specific pathway during different types of damage. Here, we report that PCAF/GCN5-mediated K163 acetylation is crucial for nucleotide excision (NER) but dispensable other Mechanistically, demonstrate the critical steady accumulation XPA at damaged sites and preferentially activates NER pathway. DNA-PK phosphorylates...
HOXB9 is a homeobox domain-containing transcription factor, playing an important role in embryonic development and cancer progression. However, the precise post-translational modifications (PTMs) of corresponding roles are unclear. Here, we report that acetyltransferase p300/CBP-associated factor (PCAF) interacts with acetylates both vivo vitro Conversely, acetylation can be reversed by deacetylase SIRT1. Furthermore, found acetylated at lysine 27 (AcK27). Functionally, contrast to wild type...
5-Fluorouracil (5-FU) combined with radiotherapy is a common treatment strategy to treat human cancers, but the underlying mechanisms of this combination remain unclear.Here, we report that NAD + -dependent deacetylase sirtuin-7 (SIRT7) protein levels were decreased due 5-FU exposure rendering colorectal cancer cells sensitive radiation.We found SIRT7 downregulation was mediated via Tat-binding Protein 1 (TBP1) proteasome-dependent pathway.Specifically, TBP1 dephosphorylated at tyrosine 381...
Sirtuin 7 (SIRT7), a member of the NAD+-dependent class III histone deacetylases, is involved in regulation various cellular processes and resisting stresses, such as hypoxia, low glucose levels, DNA damage. Interestingly, SIRT7 linked to control glycolysis, suggesting role metabolism. Given important roles SIRT7, it critical clarify how activity potentially regulated. It has been reported that some transcriptional post-transcriptional regulatory mechanisms are involved. However, little...
P53-binding protein 1 (53BP1) plays critical roles in DNA double strand break (DSB) repair by promoting non-homologous end joining (NHEJ), and loss of 53BP1 abolishes PARPi sensitivity BRCA1-deficient cells restoring homologous recombination (HR). is one the proteins initially recruited to sites DSBs via recognition H4K20me2 through Tudor-UDR domain H2AK15ub UDR motif. Although extensive studies have been conducted, it remains unclear how post-translational modification affects DSB pathway...
The N-substituents on the backbone of Ph2PN(R)Si(CH3)2CH2PPh2- and [Ph2PCH2Si(CH3)2]2N(R)-type silylated-diphosphinoamine (Si-PNP) systems have been observed to a significant impact their catalytic performance in ethylene oligomerization reactions. Cr precatalyst 3, bearing an isopropyl (iPr) substituent, affords most efficient system exhibited highest selectivity (83%) toward 1-octene (1-C8) showed activity more than 76,700 g(product)·g(Cr)−1·h–1 under experimental conditions....
Abstract One of the environmental crises facing world is pollution due to rubber auto tire destruction. The use tires in vehicles consumes 6% world's energy and causes 5% carbon dioxide emissions; it accounts for up 10% microplastic found oceans. Here, a new nanocomposite self‐assembled from hard soft elastomer matrixes designed: polybutadiene with its two hydroxy chain ends reacts 4,4'‐diphenylmethane diisocyanate form segmented polyurethane. This system first undergoes self‐assembly,...
The Notch signaling pathway controls cell growth, differentiation, and fate decisions, its dysregulation has been linked to various human genetic disorders cancers. To comprehensively understand the global organization of identify potential drug targets for Notch-related diseases, we established a protein interaction landscape pathway. By combining analyzing phenotypic data with bioinformatics analysis, greatly expanded this identified many key regulators, including...
Abstract Background Human endogenous retroviruses (HERVs), the remnants of ancient retroviruses, account for 8% human genome, but most have lost their transcriptional abilities under physiological conditions. However, mounting evidence shows that several expressed HERVs do exert biological functions. Here, we systematically characterize physiologically and examine whether they may give insight into molecular fundamentals development disease. Results We identify 13,889 across normal body...
Abstract Epigenetic mechanisms involved in gene expression play an essential role various cellular processes, including lipid metabolism. Lysine acetyltransferase 8 (KAT8), a histone acetyltransferase, has been reported to mediate de novo lipogenesis by acetylating fatty acid synthase. However, the effect of KAT8 on lipolysis is unclear. Here, we report novel mechanism involving its acetylation general control non-repressed protein 5 (GCN5) and deacetylation Sirtuin 6 (SIRT6). at K168/175...
The study aims to investigate the predictive performance of preoperative imaging features combined with tap test for outcomes ventriculoperitoneal (VP) shunt in idiopathic normal pressure hydrocephalus (iNPH). In this multicenter retrospective study, 166 iNPH patients who underwent VP surgery between August 2019 and November 2023 were included. Preoperative clinical characteristics collected. assessment at least 3 months postoperative follow-up performed. Multivariable logistic regression,...
Delphian lymph node (DLN) metastasis is common in papillary thyroid cancer (PTC). However, few studies have specifically investigated the clinicopathologic characteristics of DLN PTC. This study aimed to examine incidence, risk factors, and predictive value carcinoma. In present study, features metastatic risks were statistically analyzed by reviewing 1837 patients with carcinoma who underwent initial surgery our department between January, 2022 July, 2024. Among included was detected 925...
Mechanisms of the enhancement photocatalytic activity p–n heterojunction BiOBr/La<sub>2</sub>Ti<sub>2</sub>O<sub>7</sub> and NO oxidation are proposed.
Global climate change has become a trend and is one of the main factors affecting biodiversity patterns species distributions. Many wild animals adapt to changing living environment caused by their habitats. Birds are highly sensitive change. Understanding suitable wintering habitat Eurasian Spoonbill (Platalea leucorodia leucorodia) its response future climatic essential for protection. In China, it was listed as national grade II key protected animal in adjusted State List 2021, Near...